Results 61 to 70 of about 2,071 (187)
Clk1 mRNA levels in siRNA treated 3T3-L1 cells.
, 2013 A. The Clk1 siRNA oligos were tranfected into 3T3-L1 pre-adipocytes and total RNA was extracted and reverse transcribed after 4 days of differentiation. The levels of full length Clk1 were decreased 50% by siRNA at 25 (nM) and 50 (nM). B.
Jacqueline Romero (290584) +6 more
core +1 more source
PLoS Genetics, 2019 Gene expression dynamics can be measured in single living cells. Using a detectable transcriptionally active gene in living cells, we previously found that an mRNA undergoing several splicing events was retained at this gene after transcription until ...
Hodaya Hochberg-Laufer +5 more
doaj +1 more source
Exploring chemical space for lead identification by propagating on chemical similarity network
Computational and Structural Biotechnology Journal, 2023 Motivation: Lead identification is a fundamental step to prioritize candidate compounds for downstream drug discovery process. Machine learning (ML) and deep learning (DL) approaches are widely used to identify lead compounds using both chemical property
Jungseob Yi +8 more
doaj +1 more source
Phytotherapy Research, Volume 39, Issue 11, Page 5062-5084, November 2025.ABSTRACT To evaluate the efficacy and explore the potential mechanism of curcumin for the treatment and prevention of NSCLC. We searched six databases thoroughly for articles published before December 2024. Stata 15.0 software was applied for systematic review with meta‐analysis.
Yonglu Guo +3 more
wiley +1 more source
Clk1 mutants alter adipogenesis.
, 2013 Plasmids of Clk1 with single mutations of Akt phosphorylation site were transfected into 3T3-L1 cells and protein lysates collected after treating cells with differentiation conditions were blotted and probed for Glut4, Glut1 and adiponectin.
Jacqueline Romero (290584) +6 more
core +1 more source
PLoS ONE, 2023 Streptococcus gallolyticus sp. gallolyticus (SGG) is a gut pathobiont involved in the development of colorectal cancer (CRC). To decipher SGG contribution in tumor initiation and/or acceleration respectively, a global transcriptome was performed in human
Ewa Pasquereau-Kotula +7 more
doaj +1 more source
Functional Ecology, Volume 39, Issue 11, Page 3050-3060, November 2025.Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between developing embryos and a multitude of environmental factors (e.g. climate, nutrition, social cues, stress and anthropogenic contaminants) underlie adaptive and non‐adaptive developmental plasticity and carry broad implications across ecological ...
Benjamin B. Parrott, Samantha L. Bock
wiley +1 more source
Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates. [PDF]
, 2015 Phosphorylation-dependent cell communication requires enzymes that specifically recognize key proteins in a sea of similar, competing substrates. The protein kinases achieve this goal by utilizing docking grooves in the kinase domain or heterologous ...
Hailey, Kendra L +6 more
core +1 more source
, 2021 The abnormality of RNA-binding proteins (RBPs) is closely related to the tumorigenesis and development of esophageal squamous cell carcinoma (ESCC), and has been an area of interest for research recently.
Xiong Chen (555744) +9 more
core +1 more source
Advanced Science, Volume 12, Issue 37, October 6, 2025.Ubiquitin‐mediated selective autophagy plays a critical role in antiviral innate immunity. The study shows that upon RNA virus infection, cytoplasmic API5 undergoes SRPK1‐dependent phosphorylation at S464, which in turn suppresses p62 K141 ubiquitination‐dependent autophagy.
Tingjuan Deng +10 more
wiley +1 more source