Results 51 to 60 of about 2,071 (187)

Whole‐transcriptome sequencing analyses identified exosomal circular RNAs in the plasma of pancreatic cancer patients as novel blood‐based biomarkers of disease

VIEW, EarlyView.
Pancreatic cancer (PaCa) has a poor prognosis, with low resection rates and high relapse rates, highlighting the urgent need for novel diagnostic biomarkers. Here, we performed whole‐transcriptome sequencing of plasma‐derived exosomes from PaCa patients and identified several differentially expressed circular RNAs (circRNAs).
Xiaomeng He, Yang Di, Lixiang Sun, Zhirong Wu, Mengting Luo, Xin Zhang, Huaqin Sun, Wanli Xu, Wenchuan Wu, Boheng Zhang, Jin Wang   +10 more
wiley   +1 more source

Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy

Retrovirology, 2011
Background RNA processing plays a critical role in the replication of HIV-1, regulated in part through the action of host SR proteins. To explore the impact of modulating SR protein activity on virus replication, the effect of increasing or inhibiting ...
Dobson Wendy, Mao Annie YQ, Balachandran Ahalya, Wong Raymond, Gray-Owen Scott, Cochrane Alan   +5 more
doaj   +1 more source

Regulatory interplay between SR proteins governs CLK1 kinase splice variants production. [PDF]

RNA
The CLK1 kinase phosphorylates SR proteins to modulate their splicing regulatory activity. Skipping of alternative exon 4 on theCLK1pre-mRNA produces a CLK1 variant lacking the catalytic site. Here, we aimed to understand how various SR proteins integrate into the regulatory program that controlsCLK1exon 4 splicing.
Shkreta L, Delannoy A, Toutant J, Chabot B.   +3 more
europepmc   +3 more sources

Ceramidonines, Fused 3,9‐Diazaperylenes, and Related Compounds: From Synthesis to Physicochemical Properties and Evaluation as Inhibitors of PIM Kinases

ChemistryEurope, Volume 4, Issue 5, May 2026.
Ceramidonines, benzo‐fused 3,9‐diazaperylenes and related compounds were synthesized, and their properties studied. Substituted ceramidonines were synthesized by cyclization of 1‐(arylamino)anthraquinones under acidic conditions. These key intermediates were prepared either by copper‐promoted N‐arylation of 1‐aminoanthraquinone with iodoarenes or, more
Ahlem N. Khelf‐Maghraoui, Nicolas Mast, William Erb, Lionel Nauton, Pascale Moreau, Nicolas Richy, Guillaume Calvez, Yann Molard, Olivier Mongin, Jean‐Pierre Hurvois, Thierry Roisnel, Charline Piroud, Thomas Robert, Stéphane Bach, Ghenia Bentabed‐Ababsa, Florence Mongin   +15 more
wiley   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

The Release of SR Protein from CLK1 Mediated by SRPK2

, 2021
Serine-arginine rich splicing factor (SR Protein/SRSF) is a family of protein involves in both constitutive and alternative RNA splicing. They contain one or two RNA-recognition motif(s) (RRM) at the N terminus and a serine-arginine rich region (RS ...

core  

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao, Lei Zhao, Yannan Lian, Zhiwei Liu, Yaqi Li, Xuege Wang, Mingya Zhang, Ni Li, Jingli Guo, Danqing Shen, Shaobo Mo, Jiahao Li, Linhui Zhai, Jiahui Ni, Sangkyu Lee, Bin Liu, Jing Li, Fei Wang, Junjie Peng, Jun Qin, Minjia Tan   +20 more
wiley   +1 more source

Ladostigil Attenuates Induced Oxidative Stress in Human Neuroblast-like SH-SY5Y Cells

Biomedicines, 2021
A hallmark of the aging brain is the robust inflammation mediated by microglial activation. Pathophysiology of common neurodegenerative diseases involves oxidative stress and neuroinflammation.
Keren Zohar, Elyad Lezmi, Tsiona Eliyahu, Michal Linial   +3 more
doaj   +1 more source

Ras Homolog Enriched in Brain Protein Reverses Amyloid Beta‐Induced Escape of Inflammatory Cytokine mRNAs From Immunoisolated RNA Processing Bodies of Glioblastoma Cells

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
A detergent‐based method, combined with immunoprecipitation using an anti‐P‐body component‐specific antibody, was used to isolate RNAs associated with RNA processing bodies (PBs) from both neuronal and glial cells. In neurons, β‐amyloid oligomers helped to trap specific mRNAs related to neuronal differentiation into PBs.
Sritama Ray, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source