Results 41 to 50 of about 2,071 (187)
Data_Sheet_3_Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity.PDF
, 2021 Increasing energy expenditure by promoting “browning” in adipose tissues is a promising strategy to prevent obesity and associated diabetes. To uncover potential targets of cold exposure, which induces energy expenditure, we performed phosphoproteomics ...
Zhenguo Wang (841547) +11 more
core +1 more source
Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. [PDF]
PLoS ONE, 2018 Cdc2-like kinases (CLKs) represent a family of serine-threonine kinases involved in the regulation of splicing by phosphorylation of SR-proteins and other splicing factors.
Anne Walter +8 more
doaj +1 more source
Insights into the Role of a Disordered N-Terminus in the Functional Regulation of CLK1 Kinase [PDF]
, 2021 SR proteins are a family of splicing factors that plays important roles in regulating alternative splicing. The function of SR proteins is heavily regulated by the extent of phosphorylation of its C-terminal RS domain. Cdc-2 like kinases (CLKs) are known
George, Athira
core
Data_Sheet_2_Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity.xlsx
, 2021 Increasing energy expenditure by promoting “browning” in adipose tissues is a promising strategy to prevent obesity and associated diabetes. To uncover potential targets of cold exposure, which induces energy expenditure, we performed phosphoproteomics ...
Zhenguo Wang (841547) +11 more
core +1 more source
In Vivo Regulation of Alternative Pre-mRNA Splicing by the Clk1 Protein Kinase [PDF]
Molecular and Cellular Biology, 1997 Controlled expression of cellular and viral genes through alternative precursor messenger RNA (pre-mRNA) splicing requires serine/arginine-rich (SR) proteins. The Clk1 kinase, which phosphorylates SR proteins, is regulated through alternative splicing of the Clk1 pre-mRNA, yielding mRNAs encoding catalytically active and truncated inactive polypeptides
P I, Duncan +3 more
openaire +2 more sources
BMC Cancer, 2018 Background Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer associated genes using the ...
Elizabeth Bowler +9 more
doaj +1 more source
SGC-CLK-1: A chemical probe for the Cdc2-like kinases CLK1, CLK2, and CLK4
Current Research in Chemical Biology, 2023 Small molecule modulators are important tools to study both basic biology and the complex signaling of protein kinases. The cdc2-like kinases (CLK) are a family of four kinases that have garnered recent interest for their involvement in a diverse set of diseases such as neurodegeneration, autoimmunity, and many cancers.
Deanna Tiek +19 more
openaire +2 more sources
PLoS ONE, 2014 The Dyrk family of protein kinases is implicated in the pathogenesis of several diseases, including cancer and neurodegeneration. Pharmacological inhibitors were mainly described for Dyrk1A so far, but in fewer cases for Dyrk1B, Dyrk2 or other isoforms ...
Christian Schmitt +7 more
doaj +1 more source
Scientific Reports, 2021 Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and of ...
Simon Uzor +11 more
doaj +1 more source
, 2013 A. 3T3-L1 cells were transfected with control (empty plasmid) and phospho-Akt site mutant Clk1 as indicated. Proteins were immunoprecipitated by Akt antibody, blot were then probed with either Clk1 or Akt antibody. B.
Jacqueline Romero (290584) +6 more
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