Results 31 to 40 of about 2,071 (187)
Structure Activity Relationship Studies around
Molecules, 2022 Three series of our lead CLK1 inhibitor DB18 have been designed, synthetized and tested against CLKs and DYRK1A kinases. Their cytotoxicity was subsequently measured on seven representative cancer cell lines.
Dabbugoddu Brahmaiah +15 more
doaj +1 more source
The Identification of Prognostic and Metastatic Alternative Splicing in Skin Cutaneous Melanoma
Cancer Control, 2022 Skin cutaneous melanoma (SKCM) is a type of highly invasive cancer originated from melanocytes. It is reported that aberrant alternative splicing (AS) plays an important role in the neoplasia and metastasis of many types of cancer.
Runzhi Huang +14 more
doaj +1 more source
CLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance Proteome size is greatly enhanced through alternative mRNA splicing, a process catalyzed by the macromolecular spliceosome. The initial step in spliceosome assembly involves the binding of U1 snRNP to the 5′ splice site in mRNA. SR proteins ensure the fidelity of this step by simultaneously binding to mRNA and U1-70K, a protein ...
Brandon E. Aubol +4 more
openaire +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 A library of substituted indolo[2,3-c]quinolone-6-ones was developed as simplified Lamellarin isosters. Synthesis was achieved from indole after a four-step pathway sequence involving iodination, a Suzuki-Miyaura cross-coupling reaction, and a reduction ...
Sreenivas Avula +11 more
doaj +1 more source
Controlling clots with Clk1 [PDF]
The Journal of Experimental Medicine, 2006 Platelets are critical blood cells involved in clotting. An early step in clot construction requires tissue factor (TF), but whether platelets make TF was unknown. New work by Schwertz et al. (page 2433) reveals that these nuclei-free cells doproduce TF by cytoplasmic splicing and further identify the kinase Clk1 as a splicing activator.
openaire +1 more source
A CLK1-KKT2 Signaling Pathway Regulating Kinetochore Assembly in Trypanosoma brucei
mBio, 2021 In eukaryotic cells, kinetochores are large protein complexes that link chromosomes to dynamic microtubule tips, ensuring proper segregation and genomic stability during cell division.
Manuel Saldivia +7 more
doaj +1 more source
An extensive program of periodic alternative splicing linked to cell cycle progression
eLife, 2016 Progression through the mitotic cell cycle requires periodic regulation of gene function at the levels of transcription, translation, protein-protein interactions, post-translational modification and degradation. However, the role of alternative splicing
Daniel Dominguez +5 more
doaj +1 more source
Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis. [PDF]
PLoS Neglected Tropical Diseases, 2015 BACKGROUND:Urinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3), a member of the vertebrate C-type lectin super family, has recently ...
Justin S Antony +3 more
doaj +1 more source
Data_Sheet_1_Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity.xlsx
, 2021 Increasing energy expenditure by promoting “browning” in adipose tissues is a promising strategy to prevent obesity and associated diabetes. To uncover potential targets of cold exposure, which induces energy expenditure, we performed phosphoproteomics ...
Zhenguo Wang (841547) +11 more
core +1 more source
Journal of Integrative Agriculture, 2018 Mitogen-activated protein kinase (MAPK) cascades play an important role in extracellular signal transduction and are involved in the pathogenicity of fungal pathogens to host plants.
Xuan NI +6 more
doaj +1 more source