Results 11 to 20 of about 2,071 (187)

Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases [PDF]

Molecules, 2021
Pim kinases (proviral integration site for Moloney murine leukemia virus kinases) are overexpressed in various types of hematological malignancies and solid carcinomas, and promote cell proliferation and survival.
Isabelle Ourliac-Garnier, Cedric Loge, Florence O Mccarthy   +2 more
exaly   +9 more sources

CLK1/CLK2-driven signalling at the Leishmania kinetochore is captured by spatially referenced proximity phosphoproteomics [PDF]

Communications Biology, 2022
Combination of proximity biotinylation and protein cross-linking allows proximity phosphoproteomics of the kinetochore in Leishmania parasites during the cell cycle and captures perturbations at the kinetochore after treatment with a protein kinase ...
Vincent Geoghegan, Juliana B. T. Carnielli, Nathaniel G. Jones, Manuel Saldivia, Sergios Antoniou, Charlotte Hughes, Rachel Neish, Adam Dowle, Jeremy C. Mottram   +8 more
doaj   +6 more sources

Regulation of influenza A virus mRNA splicing by CLK1 [PDF]

Antiviral Research, 2019
Influenza A virus carries eight negative single-stranded RNAs and uses spliced mRNAs to increase the number of proteins produced from them. Several genome-wide screens for essential host factors for influenza A virus replication revealed a necessity for splicing and splicing-related factors, including Cdc-like kinase 1 (CLK1).
Anita Artarini, Michael Meyer, Yu Jin Shin, Kilian Huber, Nikolaus Hilz, Franz Bracher, Daniel Eros, Laszlo Orfi, Gyorgy Keri, Sigrid Goedert, Martin Neuenschwander, Jens von Kries, Yael Domovich-Eisenberg, Noa Dekel, István Szabadkai, Mario Lebendiker, Zoltán Horváth, Tsafi Danieli, Oded Livnah, Olivier Moncorgé, Rebecca Frise, Wendy Barclay, Thomas F. Meyer, Alexander Karlas   +23 more
openaire   +6 more sources

Phosphoproteomic analysis identifies CLK1 as a novel therapeutic target in gastric cancer [PDF]

Gastric Cancer, 2020
Phosphorylation is an important regulatory mechanism of protein activity in cells. Studies in various cancers have reported perturbations in kinases resulting in aberrant phosphorylation of oncoproteins and tumor suppressor proteins.In this study, we carried out quantitative phosphoproteomic analysis of gastric cancer tissues and corresponding ...
Babu, Niraj, Pinto, Sneha M., Biswas, Manjusha, Subbannayya, Tejaswini, Rajappa, Manoj, Mohan, Sonali V., Advani, Jayshree, Rajagopalan, Pavithra, Sathe, Gajanan, Syed, Nazia, Radhakrishna, Vinod D., Muthusamy, Oliyarasi, Navani, Sanjay, Kumar, Rekha V., Gopisetty, Gopal, Rajkumar, Thangarajan, Radhakrishnan, Padhma, Thiyagarajan, Saravanan, Pandey, Akhilesh, Gowda, Harsha, Majumder, Pradip, Chatterjee, Aditi   +21 more
openaire   +5 more sources

Autoregulation of the human splice factor kinase CLK1 through exon skipping and intron retention [PDF]

Gene, 2018
Alternative splicing is a key process required for the regulation of gene expression in normal development and physiology. It is regulated by splice factors whose activities are in turn regulated by splice factor kinases and phosphatases. The CDC-like protein kinases are a widespread family of splice factor kinases involved in normal physiology and in ...
Uzor, Simon, Zorzou, Panagiota, Bowler, Elisabeth, Porazinski, Sean, Wilson, Ian D, Ladomery, Michaek   +5 more
openaire   +4 more sources

Er fullstendig selektiv inhibering av CLK1 en mulighet? [PDF]

, 2021
Cdc2-like kinase 1 (CLK1) er en proteinkinase som er involvert i pre-mRNA spleising. Den er sammenkoblet med flere sykdommer. Derfor er inhibering av CLK1 er et svært aktuelt tema, da dette kan forhindre flere lidelser. Ved å gjøre et litteratursøk blir det forsøkt å svare på problemstillingen: "Er selektiv inhibering av CLK1 mulig, og hvis det er ...
Lokøy, Renate
core   +3 more sources

Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core

Molecules, 2022
The DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase) family of protein kinases is involved in the pathogenesis of several neurodegenerative diseases.
Mihaela-Liliana Ţînţaş, Ludovic Peauger, Florent Alix, Cyril Papamicaël, Thierry Besson, Jana Sopková-de Oliveira Santos, Vincent Gembus, Vincent Levacher   +7 more
doaj   +2 more sources

N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation [PDF]

Biochemical Journal, 2014
SR proteins are essential splicing factors that are regulated through multisite phosphorylation of their RS (arginine/serine-rich) domains by two major families of protein kinases. The SRPKs (SR-specific protein kinases) efficiently phosphorylate the arginine/serine dipeptides in the RS domain using a conserved docking groove in the kinase domain.
Aubol, Brandon E, Plocinik, Ryan M, Keshwani, Malik M, McGlone, Maria L, Hagopian, Jonathan C, Ghosh, Gourisankar, Fu, Xiang-Dong, Adams, Joseph A   +7 more
openaire   +5 more sources

Machine learning-based selection of immune cell markers in osteosarcoma: prognostic determination and validation of CLK1 in disease progression [PDF]

Frontiers in Immunology
IntroductionOsteosarcoma (OS) is a malignancy of the bone that mainly afflicts younger individuals. Despite existing treatment approaches, patients with metastatic or recurrent disease generally face poor prognoses.
Nan Zhang, Zhou Haizhen, Runqi Zhang, Xiaoju Li   +3 more
doaj   +2 more sources

Research towards selective inhibition of the CLK3 kinase [PDF]

Beilstein Journal of Organic Chemistry
The cdc2-like kinases (CLKs), are a family of kinases that attracted recently the interest of scientists due to their significant biological roles, in particular in the regulation of the mRNA splicing process. Among the four isoforms of CLKs, CLK3 is the
Vinay Kumar Singh, Frédéric Justaud, Dabbugoddu Brahmaiah, Nangunoori Sampath Kumar, Blandine Baratte, Thomas Robert, Stéphane Bach, Chada Raji Reddy, Nicolas Levoin, René L. Grée   +9 more
doaj   +2 more sources