CLK1 is a potential tumor suppressor for NSCLC by regulating cell proliferation and immune infiltration [PDF]
Frontiers in Cell and Developmental BiologyBackgroundLung cancer is the malignancy with the highest global incidence and mortality. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of cases and is characterized by complex drug resistance and poor prognosis.
Rui Ma +6 more
doaj +2 more sources
Regulation of CLK1 Isoform Expression by Alternative Splicing in Activated Human Monocytes Contributes to Activation-Associated TNF Production [PDF]
CellsAlternative splicing is a key regulator of immune regulation by enabling rapid and context-specific responses. However, the role of splicing regulators such as CDC-like kinase 1 (CLK1) in monocyte biology remains poorly defined.
Maurice J. H. van Haaren +7 more
doaj +2 more sources
Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity
Frontiers in Physiology, 2021 Increasing energy expenditure by promoting “browning” in adipose tissues is a promising strategy to prevent obesity and associated diabetes. To uncover potential targets of cold exposure, which induces energy expenditure, we performed phosphoproteomics ...
Xiaojing Gao +2 more
exaly +3 more sources
Stable H-bond networks are crucial for selective CLK1 inhibition: a computational perspective [PDF]
Frontiers in ChemistryStudying the selectivity mechanism of inhibitors towards highly similar isoforms is an important task in the development of new drugs, which are designed to avoid the undesired side effects in vivo.
Yuzhou Huang +5 more
doaj +2 more sources
Molecules, 2021 Clks have been shown by recent studies to be promising targets for cancer therapy, as they are considered key regulators in the process of pre-mRNA splicing, which in turn affects every aspect of tumor biology.
Ahmed K Elhady +2 more
exaly +3 more sources
Journal of Hematology and Oncology, 2021 Background Both aberrant alternative splicing and m6A methylation play complicated roles in the development of pancreatic cancer (PC), while the relationship between these two RNA modifications remains unclear.
Jiang-Zhi Chen, Yi Huang, Long Huang
exaly +2 more sources
Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment
Molecules, 2015 The rapid evolution of influenza virus makes antiviral drugs less effective, which is considered to be a major bottleneck in antiviral therapy. The key proteins in the host cells, which are related with the replication cycle of influenza virus, are ...
Ai-Lin Liu, Lishu Zheng, Guan-Hua Du
exaly +3 more sources
Structure-guided screening identified bioactive phytoconstituents Hernandonine and Anolobine as potential inhibitors of dual specificity protein kinase CLK1 [PDF]
Scientific ReportsNeurodegenerative diseases such as Alzheimer’s disease (AD) are becoming a global health concern because of their progressive nature and the extent of the disability they cause to the affected individuals.
Sumaiya Khan +5 more
doaj +2 more sources
Comprehensive bioinformatics evaluation uncovers the possible oncogenic contribution of acrylamide to endometrial cancer [PDF]
Discover OncologyBackground Endometrial cancer (EC) is a prevalent gynecological malignancy with increasing incidence worldwide. Despite advancements in treatment, challenges such as tumor recurrence and chemoresistance persist.
Yiting Zou +3 more
doaj +2 more sources
Integrating network pharmacology and transcriptomics to identify solasonine’s anti-osteosarcoma targets and experimental validation [PDF]
Frontiers in OncologyBackgroundOsteosarcoma (OS) patients face the challenge of having few effective therapeutic drugs. Solasonine(SS)is an active component of TCM against OS cells. This study aims to identify the key targets of solasonine in treating OS.MethodsIn this study,
Daihao Wei +4 more
doaj +2 more sources