Results 71 to 80 of about 2,071 (187)
The CLK Family Kinases, CLK1 and CLK2, Phosphorylate and Activate the Tyrosine Phosphatase, PTP-1B [PDF]
Journal of Biological Chemistry, 1999 The protein-tyrosine phosphatase PTP-1B is an important regulator of intracellular protein tyrosine phosphorylation, and is itself regulated by phosphorylation. We report that PTP-1B and its yeast analog, YPTP, are phosphorylated and activated by members of the CLK family of dual specificity kinases.
F M, Moeslein, M P, Myers, G E, Landreth
openaire +2 more sources
Specificity of the kinase inhibitors for CLK1, CLK2, SRPK1, SRPK2, and SRPK3.
, 2015 CLK1, SRPK1, SRPK2, and SRPK3 assays were performed with 5 µM ATP, and the CLK2 assay was performed with 20 µM ATP. The definition and determination of the IC50 values are described in the Methods.Specificity of the kinase inhibitors for CLK1, CLK2 ...
Risa Miyashita (683052) +7 more
core +1 more source
Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells
Frontiers in Immunology, 2020 Alpha-synuclein (αSynAgg) are pathological hallmarks of Parkinson's disease (PD) and other synucleinopathies that induce microglial activation and immune-mediated neurotoxicity, but the molecular mechanisms of αSynAgg-induced immune activation are poorly
Souvarish Sarkar +18 more
doaj +1 more source
Stress alters hypothalamic gene expression in adolescent male Golden hamsters
Journal of Neuroendocrinology, Volume 37, Issue 9, September 2025.Abstract In Golden hamsters (Mesocricetus auratus), a two‐week exposure to chronic social stress in adolescence causes acceleration of agonistic behavior, enhanced adult aggression, impaired waiting impulsivity, and higher food intake, body fat, and long‐term increased body weight.
Kevin M. Moran +3 more
wiley +1 more source
, 2021 The abnormality of RNA-binding proteins (RBPs) is closely related to the tumorigenesis and development of esophageal squamous cell carcinoma (ESCC), and has been an area of interest for research recently.
Xiong Chen (555744) +9 more
core +1 more source
Development of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1)
Frontiers in Immunology, 2018 Collectin-11 (CL-11) is a pattern recognition molecule of the lectin pathway of complement with diverse functions spanning from host defense to embryonic development.
Rafael Bayarri-Olmos +5 more
doaj +1 more source
U1‐70K and U1A and tau pathogenesis in demented and non‐demented individuals with Down syndrome
Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.Abstract INTRODUCTION Splicing protein mislocalization is associated with tau pathogenesis, but its role in Down syndrome (DS) is under‐investigated. METHODS Spliceosome associations with tau and plaque pathology were examined in frontal cortex from DS with dementia (DSD+) and without dementia (DSD−) using quantitative immunoblotting and ...
Sylvia E. Perez +6 more
wiley +1 more source
Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy [PDF]
, 2017 Duchenne muscular dystrophy (DMD) is a fatal progressive muscle-wasting disease. Various attempts are underway to convert severe DMD to a milder phenotype by modulating the splicing of the dystrophin gene and restoring its expression.
Okuno, Yukiko +25 more
core +1 more source
, 2021 The abnormality of RNA-binding proteins (RBPs) is closely related to the tumorigenesis and development of esophageal squamous cell carcinoma (ESCC), and has been an area of interest for research recently.
Xiong Chen (555744) +9 more
core +1 more source
RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications
MedComm, Volume 6, Issue 8, August 2025.RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang +4 more
wiley +1 more source