Results 101 to 110 of about 2,071 (187)

Entwicklung neuer dualer Kinasehemmstoffe gegen Clk1, Dyrk1A und Dyrk1B

, 2014
Dyrk1A, a kinase from the CMGC group of kinases was recently identified as potential drug target for the treatment of Down Syndrome (DS) related Alzheimer’s Disease.
Schmitt, Christian
core   +1 more source

Computer-Aided Drug Design Applied to Marine Drug Discovery: Meridianins as Alzheimer’s Disease Therapeutic Agents

Marine Drugs, 2017
Computer-aided drug discovery/design (CADD) techniques allow the identification of natural products that are capable of modulating protein functions in pathogenesis-related pathways, constituting one of the most promising lines followed in drug discovery.
Laura Llorach-Pares, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Conxita Avila   +3 more
doaj   +1 more source

Overexpression of Clk1 but not SRPK1 leads to splicing factor dispersal and increases the FRAP recovery rates on the E6 gene.

, 2019
(A) The distribution of SRSF2 (green) in cells transfected with Cerulean-Clk1 (cyan) or mCherry-SRPK1 (magenta). DIC in grey. Bar = 5 μm. (B) Recovery curves of the YFP-MS2 mRNA FRAP measurements performed on the E3 and E6 transcription sites under ...
Shani Nadav-Eliyahu (8039129), Yehuda Brody (233326), Yaron Shav-Tal (105312), Rakefet Ben-Yishay (8039132), Hodaya Hochberg-Laufer (8039126), Noa Neufeld (233329)   +5 more
core   +1 more source

Clk1 mRNA splice variant levels in differentiating 3T3-L1 adipocytes.

, 2013
Pre-adipocytes were grown to confluence before initiating differentiation on day 0 with insulin, isobutylmethyxantine and methylxanthine as described in Methods. A. A schematic of Clk/Sty or Clk1.
Jacqueline Romero (290584), James Watson (183235), Denise R. Cooper (290591), Kathryn M. Gower (290587), Niketa A. Patel (290589), Gay Carter (290582), Pengfei Li (290581)   +6 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors.

PLoS ONE, 2015
DYRK1A is a pleiotropic protein kinase with diverse functions in cellular regulation, including cell cycle control, neuronal differentiation, and synaptic transmission.
Katharina Rüben, Anne Wurzlbauer, Agnes Walte, Wolfgang Sippl, Franz Bracher, Walter Becker   +5 more
doaj   +1 more source

Genetic variation of COLEC10 and COLEC11 and association with serum levels of collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1).

PLoS ONE, 2015
Collectin liver 1 (CL-L1, alias CL-10) and collectin kidney 1 (CL-K1, alias CL-11), encoded by the COLEC10 and COLEC11 genes, respectively, are highly homologous soluble pattern recognition molecules in the lectin pathway of complement.
Rafael Bayarri-Olmos, Soren Hansen, Maiken Lumby Henriksen, Line Storm, Steffen Thiel, Peter Garred, Lea Munthe-Fog   +6 more
doaj   +1 more source

Single mutant sites on Clk1 cDNA alter phosphorylation of SR proteins.

, 2013
Plasmids of single Akt site mutants of Clk1 were transfected into 3T3-L1 cells. Clk1 substrate phosphorylation levels were probed using a monoclonal antibody recognizing the Clk phosphorylation motif, mAb104, during differentiation.
Jacqueline Romero (290584), James Watson (183235), Denise R. Cooper (290591), Kathryn M. Gower (290587), Niketa A. Patel (290589), Gay Carter (290582), Pengfei Li (290581)   +6 more
core   +1 more source

Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion

, 2013
Alternative mRNA splicing is a mechanism to regulate protein isoform expression and is regulated by alternative splicing factors. The alternative splicing factor 45 (SPF45) is overexpressed in cancer, although few biological effects of SPF45 are known ...
Al-Ayoubi, Adnan M, Weed, Scott A, Conaway, LaShardai, Zheng, Hui, Bethard, Jennifer R, Bradley, Amber T, Eblen, Scott T, Liu, Yuying   +7 more
core   +1 more source

Data from CLK1 Activates YAP to Promote Intrahepatic Cholangiocarcinogenesis

<div>Abstract<p>Cdc2-like kinase 1 (CLK1) has dual-specificity kinase ability to phosphorylate tyrosine and serine/threonine protein residues. CLK1 regulates many physiologic processes and has been shown to contribute to multiple types of cancer.
Haichuan Wang, Yong Zeng, Jiwei Huang, Hongyu Zhou, Rui Xie, Lin Xu, Xuping Feng, Zheng Zhang, Zeyuan Qiang, Haotian Liao, Guoteng Qiu, Xiangzheng Chen, Shuai Xue   +12 more
openaire   +1 more source