A functional prognostic model predicts progression-free survival in patients with relapsed chronic lymphocytic leukemia treated with ibrutinib + venetoclax. [PDF]
Hermansen JU +24 more
europepmc +1 more source
Somatic Mitochondrial–Nuclear DNA Transfer in Lymphoproliferative Disorders
ABSTRACT Introduction Somatic mitochondrial–nuclear DNA transfer (SMNT) is a process by which mitochondrial DNA (mtDNA), of varying sizes, integrate into the nuclear genome and has been previously reported in solid tumours. Methods EuroClonality‐NGS DNA Capture sequencing data from 755 lymphoid malignancies and 59 lymphoid cell lines were analysed for ...
James Peter Stewart +9 more
wiley +1 more source
High-dimensional spectral flow cytometry uncovers progressive T-cell exhaustion and myeloid cell reprogramming in a CLL mouse model. [PDF]
Briesch H +9 more
europepmc +1 more source
Impact of Co‐Morbid Immunocompromise in HPV‐Associated Oropharyngeal Squamous Cell Carcinoma
Among patients with surgically resected Human Papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC), immunocompromised patients had significantly worse overall survival compared to the non‐compromised group; however, these exploratory findings should be interpreted cautiously.
Maxwell L. Weng +7 more
wiley +1 more source
Studying Chronic Lymphocytic Leukemia Microenvironment in the Multi Omics Era. [PDF]
Bucci A +11 more
europepmc +1 more source
Mucosal‐Associated Invariant T Cells in Health and Disease
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao +5 more
wiley +1 more source
Case Report and Retrospective Review of Acanthamoeba Encephalitis and Chronic Lymphocytic Leukemia, United States. [PDF]
Persico M +5 more
europepmc +1 more source
Muscle Strength and Power Changes With Gender‐Affirming Hormone Therapy
ABSTRACT Background Androgen receptors are highly expressed in upper body muscles, but changes in maximal muscle strength and power in major upper body muscles have not been investigated during gender‐affirming hormone therapy (GAHT). Objective To assess prospective changes in maximal muscle strength and muscle power from before and after 1 year of ...
Mathilde Kamp Nørlund +12 more
wiley +1 more source
ABSTRACT Post‐transplant cyclophosphamide (PT‐CY) remains the standard of care for graft‐versus‐host disease (GvHD) prophylaxis in haploidentical hematopoietic cell transplantation (HCT), yet relapse, delayed immune reconstitution, infections, and organ toxicity represent persistent and clinically meaningful limitations.
Megan J. Cracchiolo +2 more
wiley +1 more source

