Results 91 to 100 of about 363,591 (305)

Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice

Molecular Metabolism, 2019
Objective: A network of endogenous circadian clocks adapts physiology and behavior to recurring changes in environmental demands across the 24-hour day cycle. Circadian disruption promotes weight gain and type 2 diabetes development.
Isa Kolbe, Brinja Leinweber, Matthias Brandenburger, Henrik Oster   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

An Adaptive Fuzzy-PI Clock Servo Based on IEEE 1588 for Improving Time Synchronization Over Ethernet Networks

IEEE Access, 2020
A network-based control system includes many connected devices, and time synchronization plays an important role in the unified operation of those systems.
Vinh Quang Nguyen, Ton Hoang Nguyen, Jae Wook Jeon   +2 more
doaj   +1 more source

The tumor-associated YB-1 protein: new player in the circadian control of cell proliferation [PDF]

, 2016
Correct spatial and temporal control of cell proliferation is of fundamental importance for tissue homeostasis. Its deregulation has been associated with several pathological conditions.
Calabrò, Viola, di Martino, Orsola, Maria Guarino, Andrea, Mueller, Nathalie, Pagano, Cristina, Reischl, Markus, Ruggiero, Gennaro, Siauciunaite, Rima, Simon Foulkes, Nicholas, Vallone, Daniela   +9 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

SUE: A Special Purpose Computer for Spin Glass Models

, 2000
The use of last generation Programmable Electronic Components makes possible the construction of very powerful and competitive special purpose computers.
A Cruz, A Tarancón, Ballesteros, Berg, C Ungil, C.L Ullod, Christ, Creutz, Creutz, Fisher, Hoogland, J Pech, Kawashima, Marinari, Marinari, Mezard, Ogielski, Ogielski, P Téllez, Palassini, Pech, Ruiz-Lorenzo   +21 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Effect of Secret Clock Manipulation on 10 km Cycle Time Trial Performance. [PDF]

, 2010
The anticipatory RPE feedback model (Tucker 2009) proposes that during self paced exercise tasks, muscular work is continually regulated through comparison of a subconscious ‘template’ Rating of Perceived Exertion (RPE) that serves to protect against the
Renfree, Andrew, Thomas, Gavin
core  

Timing in the ALICE trigger system [PDF]

, 2007
In this paper we discuss trigger signals synchronisation and trigger input alignment in the ALICE trigger system. The synchronisation procedure adjusts the phase of the input signals with respect to the local Bunch Crossing (BC) clock and, indirectly ...
Bhasin, A, Evans, D, Jones, G T, Jovanovic, P, Jusko, A, Krivda, M, Králik, I, Lietava, Roman, Pastircák, B, Sándor, L, Urbán, J, Villalobos Baillie, O   +11 more
core   +1 more source