Modeling the Circadian Control of the Cell Cycle and Its Consequences for Cancer Chronotherapy
Biology, 2023 The mammalian cell cycle is governed by a network of cyclin/Cdk complexes which signal the progression into the successive phases of the cell division cycle.
Courtney Leung +2 more
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The GH-IGF-1 Axis in Circadian Rhythm
Frontiers in Molecular Neuroscience, 2021 Organisms have developed common behavioral and physiological adaptations to the influence of the day/night cycle. The CLOCK system forms an internal circadian rhythm in the suprachiasmatic nucleus (SCN) during light/dark input.
Weihao Wang +5 more
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Beat-to-beat cycle length variability of spontaneously beating guinea pig sinoatrial cells: relative contributions of the membrane and calcium clocks. [PDF]
PLoS ONE, 2014 The heartbeat arises rhythmically in the sino-atrial node (SAN) and then spreads regularly throughout the heart. The molecular mechanism underlying SAN rhythm has been attributed by recent studies to the interplay between two clocks, one involving the ...
Massimiliano Zaniboni +2 more
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Business cycle clocks: Time to get circular
Empirical Economics, 2023 Assessing the momentum of the business cycle is of utmost importance for policymakers and private agents. In this respect, the use of business cycle clocks has gained prominence among national and international institutions to depict the current stage of the business cycle.
Lourenço, Nuno, Rua, António
openaire +2 more sources
Circadian clock regulation of the cell cycle in the zebrafish intestine.
PLoS ONE, 2013 The circadian clock controls cell proliferation in a number of healthy tissues where cell renewal and regeneration are critical for normal physiological function.
Elodie Peyric +2 more
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Body temperature cycles: Gatekeepers of circadian clocks [PDF]
Cell Cycle, 2013 (2013). Body temperature cycles: Gatekeepers of circadian clocks. Cell Cycle: Vol. 12, No. 4, pp. 539-540.
Jörg Morf, Ueli Schibler
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Quantitative analysis of regulatory flexibility under changing environmental conditions [PDF]
, 2010 The circadian clock controls 24-h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops.
Edwards, Kieron D. +10 more
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DLL-based 4-phase duty-cycle and phase correction circuit for high frequency clock tree
MATEC Web of Conferences, 2016 In high-speed data transmission applications such as double data rate memory and double sampling ADCs, clock generation and distribution circuits must provide the clocks with precise duty cycle of 50% and sufficient timing margin.
Song Jaewoo, Shin Hee-Am, Kim Soo-Won
doaj +1 more source
A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line [PDF]
, 2019 The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock ...
Abreu, Mónica +4 more
core +1 more source
Animals, 2021 Vertebrates possess circadian clocks, driven by transcriptional–translational loops of clock genes, to orchestrate anticipatory physiological adaptations to cyclic environmental changes. This work aims to investigate how the absence of a light-dark cycle
Nuria Saiz +4 more
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