Results 31 to 40 of about 363,591 (305)

Performance boost of time-delay reservoir computing by non-resonant clock cycle

open access: yes, 2020
The time-delay-based reservoir computing setup has seen tremendous success in both experiment and simulation. It allows for the construction of large neuromorphic computing systems with only few components.
Lüdge, Kathy   +3 more
core   +1 more source

MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

open access: yesNature Communications, 2016
The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock ...
Anton Shostak   +9 more
doaj   +1 more source

Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. [PDF]

open access: yesPLoS ONE, 2010
Cell proliferation in all rapidly renewing mammalian tissues follows a circadian rhythm that is often disrupted in advanced-stage tumors. Epidemiologic studies have revealed a clear link between disruption of circadian rhythms and cancer development in ...
Susie Lee   +4 more
doaj   +1 more source

How the cell cycle clock ticks

open access: yesMolecular Biology of the Cell, 2019
Eukaryotic cell division has been studied thoroughly and is understood in great mechanistic detail. Paradoxically, however, we lack an understanding of its core control process, in which the master regulator of the cell cycle, cyclin-dependent kinase (CDK), temporally coordinates an array of complex molecular events.
Örd, Mihkel, Loog, Mart
openaire   +2 more sources

The Circadian Molecular Clock Regulates Adult Hippocampal Neurogenesis by Controlling the Timing of Cell-Cycle Entry and Exit

open access: yesCell Reports, 2013
The subgranular zone (SGZ) of the adult hippocampus contains a pool of quiescent neural progenitor cells (QNPs) that are capable of entering the cell cycle and producing newborn neurons.
Pascale Bouchard-Cannon   +4 more
doaj   +1 more source

A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception.

open access: yesPLoS Biology, 2011
The circadian clock is synchronized with the day-night cycle primarily by light. Fish represent fascinating models for deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here we have
Nicola Cavallari   +9 more
doaj   +1 more source

Pulse width control loop as a duty cycle corrector [PDF]

open access: yesSerbian Journal of Electrical Engineering, 2004
The clock distribution and generation circuitry forms a critical component of current synchronous digital systems. A digital system’s clocks must have not only low jitter, low skew, but also well-controlled duty cycle in order to facilitate versatile ...
Jovanović Goran, Stojčev Mile K.
doaj   +1 more source

Pharmacological inhibition of cryptochrome and REV-ERB promotes DNA repair and cell cycle arrest in cisplatin-treated human cells

open access: yesScientific Reports, 2021
Nucleotide excision repair (NER) and cell cycle checkpoints impact the ability of the anti-cancer drug cisplatin to inhibit cell proliferation and induce cell death.
Nadeen Anabtawi   +2 more
doaj   +1 more source

Impact of disabled circadian clock on yellow fever mosquito Aedes aegypti fitness and behaviors

open access: yesScientific Reports, 2022
Like other insects, Aedes aegypti displays strong daily patterns in host seeking and mating. Much of these behaviors are believed to be under the control of a circadian clock, an endogenous timekeeping mechanism relying on transcriptional/translational ...
Vinaya Shetty   +4 more
doaj   +1 more source

Glucocorticoids play a key role in circadian cell cycle rhythms. [PDF]

open access: yesPLoS Biology, 2007
Clock output pathways play a pivotal role by relaying timing information from the circadian clock to a diversity of physiological systems. Both cell-autonomous and systemic mechanisms have been implicated as clock outputs; however, the relative ...
Thomas Dickmeis   +7 more
doaj   +1 more source

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