Results 61 to 70 of about 363,591 (305)

Riding Tandem: Circadian Clocks and the Cell Cycle [PDF]

open access: yesCell, 2007
The circadian clock, which governs metabolic and physiological rhythms in diverse organisms, shares common features with the cell cycle. Yet, these two oscillatory systems seem to be fully independent of each other. Recent studies now reveal that some essential regulatory elements are common to both the cell cycle and circadian clock.
Hunt, Tim, Sassone-Corsi, Paolo
openaire   +2 more sources

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender   +17 more
wiley   +1 more source

Two ~35 day clocks in Her X-1: evidence for neutron star free precession [PDF]

open access: yes, 2008
We present evidence for the existence of two ~35 day clocks in the Her X-1/HZ Her binary system. ~35 day modulations are observed 1) in the Turn-On cycles with two on- and two off-states, and 2) in the changing shape of the pulse profiles which re ...
Alpar   +40 more
core   +2 more sources

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack   +39 more
wiley   +1 more source

Hydra vulgaris exhibits day-night variation in behavior and gene expression levels

open access: yesZoological Letters, 2019
Background Day–night behavioral variation is observed in most organisms, and is generally controlled by circadian clocks and/or synchronization to environmental cues.
Hiroyuki J. Kanaya   +2 more
doaj   +1 more source

The Modification of Circadian Clock Components in Soybean During Domestication and Improvement

open access: yesFrontiers in Genetics, 2020
Agricultural production is greatly dependent on daylength, which is determined by latitude. Living organisms align their physiology to daylength through the circadian clock, which is made up of input sensors, core and peripheral clock components, and ...
Man-Wah Li, Hon-Ming Lam, Hon-Ming Lam
doaj   +1 more source

EVOLUTION OF THE CIRCADIAN CLOCK IN EXTREME ENVIRONMENT: LESSONS FROM CAVEFISH. [PDF]

open access: yes, 2010
Evolution has been strongly influenced by the daily cycles of temperature and light imposed by the rotation of the Earth. Fascinating demonstrations of this are seen in extreme environments such as caves where some animals have remained completely ...
Cavallari, Nicola
core  

An electronic clock for correlated noise corrections

open access: yes, 1999
An inexpensive and portable approach to measure the time an experimental event occurs as measured by a specific electronic clock is presented. The clock resets in active synchronization with the experimental AC-power cycle.
K.K Kainz, N Adams, Sugitate, W.J Llope
core   +1 more source

Sleep Timing in Late Autumn and Late Spring Associates With Light Exposure Rather Than Sun Time in College Students [PDF]

open access: yes, 2019
Timing of the human sleep-wake cycle is determined by social constraints, biological processes (sleep homeostasis and circadian rhythmicity) and environmental factors, particularly natural and electrical light exposure. To what extent seasonal changes in
Dijk, Derk-Jan   +5 more
core   +2 more sources

Outcomes and Surgical Management of Malignant Rhabdoid Tumor of the Kidney: A Report From the Pediatric Surgical Oncology Research Collaborative

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Malignant rhabdoid tumor of the kidney (MRTK) is a rare, aggressive tumor seen in young children. The optimal timing of resection for locally advanced tumors is not well‐defined. The purpose of this study is to evaluate modern oncologic outcomes and the impact of surgical timing. Methods A multicenter retrospective review was performed
Hannah N. Rinehardt   +76 more
wiley   +1 more source

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