Results 41 to 50 of about 34,539 (304)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Design Of Modified Data Driven Clock Gating And Look Ahead Clock Gating For Low Power

International Journal of Electrical and Electronics Research, 2018
Clock signal is considered as an immense source of power dissipation in synchronous circuits because of large frequency and load. It does not carry any information but consumes high power at the switching activity which is to be avoided. So, by using clock gating we can save power by reducing unnecessary transition activity inside the gated module ...
V. Nirmaladevi, Angel Prabha
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Minimum criteria for DNA damage-induced phase advances in circadian rhythms. [PDF]

PLoS Computational Biology, 2009
Robust oscillatory behaviors are common features of circadian and cell cycle rhythms. These cyclic processes, however, behave distinctively in terms of their periods and phases in response to external influences such as light, temperature, nutrients, etc.
Christian I Hong, Judit Zámborszky, Attila Csikász-Nagy   +2 more
doaj   +1 more source

Digital computing cardiotachometer [PDF]

, 1973
A tachometer is described which instantaneously measures heart rate. During the two intervals between three succeeding heart beats, the electronic system: (1) measures the interval by counting cycles from a fixed frequency source occurring between the ...
Rasquin, J. R., Smith, H. E., Taylor, R. A.   +2 more
core   +1 more source

Issues in Implementing Latency Insensitive Protocols [PDF]

, 2004
The performance of future Systems-on-Chip will be limited by the latency of long interconnects requiring more than one clock cycle for the signals to propagate. To deal with the problem L. Carloni et alii proposed the Latency Insensitive Protocols (LIP).
Casu, Mario Roberto, Macchiarulo, Luca
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Action, arousal and subjective time [PDF]

, 2004
Saccadic chronostasis refers to the subjective temporal lengthening of the first visual stimulus perceived after an eye movement. It has been quantified using a duration discrimination task.
Allan, Allan, Bachmann, Boltz, Burle, Collet, Dennett, Duhamel, Fetterman, Franssen, Gibbon, Gibbon, Hellstroem, Hodinott-Hill, Howell, John C. Rothwell, Kielan Yarrow, Lejeune, Lejeune, Libet, Matell, Park, Patrick Haggard, Penton-Voak, Pockett, Richer, Rose, Rosenbaum, Ross, Scharlau, Schlag, Treisman, Treisman, Tyrrell, Umeno, van der Veen, Walker, Wearden, Wearden, Wearden, Wearden, Yarrow, Yarrow, Zakay   +43 more
core   +1 more source