Results 91 to 100 of about 187,082 (288)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Clonal Hematopoiesis, a Risk Condition for Developing Myeloid Neoplasia
HematoClonal hematopoiesis (CH) is an age-related process in which hematopoietic stem/progenitor cells increase their fitness due to the acquisition of mutations that lead to a proliferative advantage and to clonal expansion.
Ugo Testa +2 more
doaj +1 more source
The initial tolerance to sub-lethal Cd exposure is the same among ten naïve pond populations of Daphnia magna, but their micro-evolutionary potential to develop resistance is very different [PDF]
, 2013 A
De Meester, Luc +3 more
core +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Journal of Clinical QuestionMyelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, peripheral cytopenias, and a significant risk of progression to acute myeloid leukemia.
Nai-Bo Hu
doaj +1 more source
Evaluation of the 1986-1987 radiata pine clonal trials at Forest Research, New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Master in Applied Science at Massey University [PDF]
, 1998 Clonal forestry, the establishment of plantations using tested clones, is highly sought after by the forestry industry in New Zealand and worldwide. Clonal testing is a vital element in the process leading to clonal forestry.
Concheyro, Silvia Claudia
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Visualizing clonal evolution with clevRvis
, 2023 Accurate reconstruction of clonal evolution is essential for the application of precision oncology. It allows for the early detection of newly developing, highly aggressive subclones that might be resistant to therapy and can potentially lead to relapse. However, analysis is characterized by challenges: Often, data on only few time points are available.
Sandmann, Sarah +2 more
openaire +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Optimization Aspects of Carcinogenesis
, 2009 Any process in which competing solutions replicate with errors and numbers of their copies depend on their respective fitnesses is the evolutionary optimization process.
Brutovsky, B., Horvath, D.
core +3 more sources