Results 81 to 90 of about 187,082 (288)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Immunoglobulin NGS enhance residual disease detection and prognosis in pediatric Ph+ acute lymphoblastic leukemia

Frontiers in Immunology
In pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ B-ALL), the clinical value of highly sensitive minimal residual disease (MRD) detection by immunoglobulin next-generation sequencing (Ig-NGS), and its role for tracking ...
Lixian Chang, Lixian Chang, Jiao Chang, Jiao Chang, Beibei Zhao, Beibei Zhao, Yun Gu, Yao Zou, Yao Zou, Yumei Chen, Yumei Chen, Ye Guo, Ye Guo, Xiaojuan Chen, Xiaojuan Chen, Wenyu Yang, Wenyu Yang, Yongjuan Duan, Yongjuan Duan, Tianyuan Hu, Tianyuan Hu, Xiaoming Liu, Xiaoming Liu, Min Ruan, Min Ruan, Zefeng Lu, Shixin Lu, Xiaoxia Wang, Li Dong, Jinghua Wu, Yujiao Jia, Yujiao Jia, Xiao Liu, Xiaofan Zhu, Xiaofan Zhu, Li Zhang, Li Zhang   +36 more
doaj   +1 more source

Clonal competition within complex evolutionary hierarchies shapes AML over time

Nature Communications, 2020
Clonal evolution and heterogeneity has strong implications for treatment response in acute myeloid leukemia. Here, the authors use patient derived in vivo modelling to highlight the complex clonal and evolutionary dynamics underpinning acute myeloid ...
Carl Sandén, Henrik Lilljebjörn, Christina Orsmark Pietras, Rasmus Henningsson, Karim H. Saba, Niklas Landberg, Hanna Thorsson, Sofia von Palffy, Pablo Peña-Martinez, Carl Högberg, Marianne Rissler, David Gisselsson, Vladimir Lazarevic, Gunnar Juliusson, Helena Ågerstam, Thoas Fioretos   +15 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Zebrafish as a model to assess cancer heterogeneity, progression and relapse

Disease Models & Mechanisms, 2014
Clonal evolution is the process by which genetic and epigenetic diversity is created within malignant tumor cells. This process culminates in a heterogeneous tumor, consisting of multiple subpopulations of cancer cells that often do not contain the same ...
Jessica S. Blackburn, David M. Langenau
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

An individual-based model for the Lenski experiment, and the deceleration of the relative fitness [PDF]

, 2016
The Lenski experiment investigates the long-term evolution of bacterial populations. Its design allows the direct comparison of the reproductive fitness of an evolved strain with its founder ancestor. It was observed by Wiser et al.
Casanova, Adrián González, Kurt, Noemi, Wakolbinger, Anton, Yuan, Linglong   +3 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A variational algorithm to detect the clonal copy number substructure of tumors from scRNA-seq data

Nature Communications, 2023
The inference of clonal architectures in cancer using single-cell RNA-seq data remains challenging. Here, the authors develop SCEVAN, a variational algorithm for copy number-based clonal structure inference in single-cell RNA-seq data that can ...
Antonio De Falco, Francesca Caruso, Xiao-Dong Su, Antonio Iavarone, Michele Ceccarelli   +4 more
doaj   +1 more source

Low clonal propagation in Atlantic and Mediterranean populations of the red gorgonian Paramuricea clavata (Octocorallia) [PDF]

, 2017
Clonal propagation is a common feature of benthic marine organisms. In the present study, we investigated the contribution of clonal reproduction in the red gorgonian Paramuricea clavata. Mediterranean populations of P.
Andrea Peirano, Carpine, Chen, Chiara Lombardi, Harmelin, Henrique Queiroga, Joana Boavida, Joanna Pilczynska, Lasker, Mokhtar-Jamaï, Peirano, Perez, Silvia Cocito, Stoddart, Toonen, Williams   +15 more
core   +5 more sources