Results 241 to 250 of about 187,082 (288)

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

LINC01235 Promotes Clonal Evolution through DNA Replication Licensing-Induced Chromosomal Instability in Breast Cancer. [PDF]

Adv Sci (Weinh)
Zhang Q, Wang X, Shao Z, Zhang Y, Zhang L, Chen M, Zhou X, Zhu H, Zhou Y, Lu X, Li P, Chi W, Li L, Shao ZM, Huang S, Xue J, Chi Y, Wu J, Xiu B.   +18 more
europepmc   +1 more source

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Multiple Myeloma Insights from Single-Cell Analysis: Clonal Evolution, the Microenvironment, Therapy Evasion, and Clinical Implications. [PDF]

Cancers (Basel)
Li S, Liu J, Peyton M, Lazaro O, McCabe SD, Huang X, Liu Y, Shi Z, Zhang Z, Walker BA, Johnson TS.   +10 more
europepmc   +1 more source

Emergence and Cytogenetic Clonal Evolution of Chromosome 7 Abnormalities in Myeloid Malignancies: Investigating the Role of Telomere Dysfunction. [PDF]

Int J Mol Sci
Baldazzi C, Bandini L, Robustelli V, Patuelli A, Venturi C, Grassi A, Marzocchi G, Ielpo A, Solli V, Bochicchio MT, Paolini S, Sartor C, Zingarelli F, Curti A, Ottaviani E, Testoni N.   +15 more
europepmc   +1 more source

Molecular profiling reveals novel therapeutic targets and clonal evolution in ovarian clear cell carcinoma. [PDF]

BMC Cancer
Chao A, Huang CY, Yu W, Lin CY, Lin H, Chao AS, Lin CT, Chou HH, Huang KG, Huang HJ, Chang TC, Rozen SG, Wu RC, Lai CH.   +13 more
europepmc   +1 more source

Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNA

Williams MJ, Vázquez-García I, Tam G, Wu M, Varice N, Havasov E, Shi H, Satas G, Lees HJ, Lee JJ, Myers MA, Zatzman M, Rusk N, Ali E, Shah RH, Berger MF, Mohibullah N, Lakhman Y, Chi DS, Abu-Rustum NR, Aghajanian C, McPherson A, Zamarin D, Loomis B, Weigelt B, Friedman CF, Shah SP.   +26 more
europepmc   +1 more source

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A Clonal Evolution Simulator for Planning Somatic Evolution Studies

Journal of Computational Biology, 2022
Somatic evolution plays a key role in development, cell differentiation, and normal aging, but also in diseases such as cancer. Understanding mechanisms of somatic mutability and how they can vary between cell lineages will likely play a crucial role in biological discovery and medical applications.
Arjun, Srivatsa, Haoyun, Lei, Russell, Schwartz   +2 more
openaire   +2 more sources

Clonal Evolution in Multiple Myeloma

Clinical Lymphoma Myeloma and Leukemia, 2016
Multiple myeloma (MM) is the second most common hematologic malignancy encountered among patients in the United States. The last decade has seen incremental improvements in the survival of patients with MM. These advances are, to a large extent, attributable to the addition of proteasome inhibitors and immunomodulatory drugs to the armamentarium of ...
Bita, Fakhri, Ravi, Vij
openaire   +2 more sources

Clonal Evolution in Aplastic Anemia

Hematology, 2011
AbstractCurrent immunosuppressive treatment (IST) induces remissions in 50%-70% of patients with aplastic anemia (AA) and result in excellent long-term survival. In recent years, the survival of refractory patients has also improved. Apart from relapse and refractoriness to IST, evolution of clonal diseases, including paroxysmal nocturnal ...
Manuel G, Afable, Ramon V, Tiu, Jaroslaw P, Maciejewski   +2 more
openaire   +2 more sources