Results 251 to 260 of about 187,082 (288)
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Clonal evolution in cutaneous malignant histiocytosis
Clinical and Experimental Dermatology, 1985Summary A 56–year-old woman is reported with malignant histiocytosis which for 17 months was confined to the skin but eventually involved lymph nodes, blood and bone marrow. Using DN'A measurements by flow cytometry a clonal evolution from an abnormal hyperdiploid to a hypotetraploid cell clone took place when the patient went from the cutaneous to ...
G L, Wantzin +3 more
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Clonal Evolution Models of Tumor Heterogeneity
American Society of Clinical Oncology Educational Book, 2015Somatic/clonal evolution is the process of sequential acquisition of vertically transmittable genetic/epigenetic elements in multicellular organisms. Cancer is the result of somatic evolution. Understanding the processes that shape the evolution of individual tumors might help us to treat cancer more efficiently.
Liran I, Shlush, Dov, Hershkovitz
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Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules
Hepatology, 1991To determine the clonal evolution of hepatocellular carcinoma, the integrated hepatitis B virus DNA patterns of the main tumor, satellites and/or metastatic lesions were analyzed by Southern-blot hybridization in 28 hepatocellular carcinomas, including three HBsAg-seronegative cases.
H C, Hsu +5 more
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Clonal evolution in chronic myelogenous leukemia
Hematology/Oncology Clinics of North America, 2004Clonal evolution (CE) may be a marker of disease progression in chronic myelogenous leukemia (CML) and is thought to reflect the genetic instability of the highly proliferative CML progenitors. The frequency of CE increases with advancing stage, rising from 30%in accelerated phase and up to 80% in blast crisis.
Jorge, Cortes, Michael E, O'Dwyer
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Clonal evolution of lung tumors.
Cancer research, 1996Lung tumors, particularly squamous cell carcinomas, are believed to develop through a series of morphological abnormalities, driven by underlying somatic genetic changes. One way of studying this process is to analyze candidate somatic genetic changes in samples of squamous metaplasia and bronchial dysplasia of varying degrees of severity as well as ...
G T, Chung +5 more
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[Clonal evolution in leukemia].
Zhongguo shi yan xue ye xue za zhi, 2015The theory of evolution of tumor cell population has been established for nearly 40 years. It was widely accepted for research and clinical anti-tumor treatment. Recently, it was suggested that cancer stem cells are the unit of evolution. Considering recent advances on genesis of tumor and leukemia with ecological and evolutionary views, this article ...
Ke-Fu, Wu +4 more
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Mutation signatures reveal clonal evolution
Blood, 2023Yoke Seng Lee, Peter van Galen
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Multi-dimensional control of clonal evolution
Nature Reviews Immunology, 2017Michael McHeyzer-Williams describes a 1998 study by Avi Kupfer and colleagues that transformed the view of cognate T helper cell–B cell crosstalk.
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Clonal Evolution and Childhood Tumors
1982Many of the clinical and biological characteristics of tumor development appear to fit with the view that most neoplasms are unicellular in origin (i.e., ‘clones’) and that tumor progression results from ‘clonal evolution’, the sequential appearance within unstable neoplastic clones of subpopulations which are more and more genetically aberrant.
Peter C. Nowell, Gloria B. Balaban
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Cancer sequencing unravels clonal evolution
Nature Biotechnology, 2012Characterization of tumor heterogeneity at the sequence level presents new challenges and opportunities for targeted therapies.
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