Results 1 to 10 of about 95,784 (161)

Clonal Expansion in Cardiovascular Pathology [PDF]

JACC: Basic to Translational Science
Summary: Clonal expansion refers to the proliferation and selection of advantageous “clones” that are better suited for survival in a Darwinian manner.
Alexander Lin, BEng (Hons), Mairi Brittan, PhD, Andrew H. Baker, PhD, Stefanie Dimmeler, PhD, Edward A. Fisher, MD, PhD, Judith C. Sluimer, PhD, Ashish Misra, PhD   +6 more
doaj   +6 more sources

Clonal expansion in normal tissues. [PDF]

Cancer Sci
AbstractCancer originates from a single ancestral cell that acquires a driver mutation, which confers a growth or survival advantage, followed by the acquisition of additional driver mutations by descendant cells. Recently, it has become evident that somatic cell mutations accumulate in normal tissues with aging and exposure to environmental factors ...
Maeda H, Kakiuchi N.
europepmc   +4 more sources

Dynamics of latent HIV under clonal expansion.

PLoS Pathogens, 2021
The HIV latent reservoir exhibits slow decay on antiretroviral therapy (ART), impacted by homeostatic proliferation and activation. How these processes contribute to the total dynamic while also producing the observed profile of sampled latent clone ...
John M Murray
doaj   +4 more sources

Clonal hematopoiesis: elements associated with clonal expansion and diseases. [PDF]

Blood Res
Abstract Clonal hematopoiesis (CH), characterized by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations, has emerged as a significant age-related phenomenon with profound implications for human health. While initially recognized in the 1960s, recent technological advances have revealed its complex nature and ...
Ryu G, Koh Y, Jaiswal S, Yoon SS.
europepmc   +3 more sources

Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells [PDF]

Genome Biology
Background Mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, but their efficacy as reliable lineage markers are hindered by the complex dynamics of mtDNA in somatic tissues.
Xin Wang, Kun Wang, Weixing Zhang, Zhongjie Tang, Hao Zhang, Yuying Cheng, Da Zhou, Chao Zhang, Wen-Zhao Zhong, Qing Ma, Jin Xu, Zheng Hu   +11 more
doaj   +2 more sources

Using DNA methylation patterns to infer tumor ancestry. [PDF]

PLoS ONE, 2010
Exactly how human tumors grow is uncertain because serial observations are impractical. One approach to reconstruct the histories of individual human cancers is to analyze the current genomic variation between its cells.
You Jin Hong, Paul Marjoram, Darryl Shibata, Kimberly D Siegmund   +3 more
doaj   +1 more source

Telomere-length dependent T-cell clonal expansion: A model linking ageing to COVID-19 T-cell lymphopenia and mortality

EBioMedicine, 2022
Summary: Background: Severe COVID-19 T-cell lymphopenia is more common among older adults and entails poor prognosis. Offsetting the decline in T-cell count during COVID-19 demands fast and massive T-cell clonal expansion, which is telomere length (TL ...
James J. Anderson, Ezra Susser, Konstantin G. Arbeev, Anatoliy I. Yashin, Daniel Levy, Simon Verhulst, Abraham Aviv   +6 more
doaj   +1 more source

Why the HIV Reservoir Never Runs Dry: Clonal Expansion and the Characteristics of HIV-Infected Cells Challenge Strategies to Cure and Control HIV Infection

Viruses, 2021
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target proviral populations in cells that persist for prolonged periods and that can undergo clonal expansion.
Chuen-Yen Lau, Matthew A. Adan, Frank Maldarelli   +2 more
doaj   +1 more source

Genetic instability and clonal expansion [PDF]

Journal of Theoretical Biology, 2006
Inactivation of tumor suppressor genes can lead to clonal expansion. We study the evolutionary dynamics of this process and calculate the probability that inactivation of a tumor suppressor gene is preceded by mutations in genes that confer genetic instability.
Nowak, Martin A., Michor, Franziska, Iwasa, Yoh   +2 more
openaire   +2 more sources

A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

iScience, 2023
Summary: Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells (ECs), and one potential origin is clonal selection.
Aneel R. Bhagwani, Mehboob Ali, Bryce Piper, Mingjun Liu, Jaylen Hudson, Neil Kelly, Srimathi Bogamuwa, Hu Yang, James D. Londino, Joseph S. Bednash, Daniela Farkas, Rama K. Mallampalli, Mark R. Nicolls, John J. Ryan, A.A. Roger Thompson, Stephen Y. Chan, Delphine Gomez, Elena A. Goncharova, Laszlo Farkas   +18 more
doaj   +1 more source