Results 1 to 10 of about 2,119,256 (322)

Clonal Expansion in Cardiovascular Pathology. [PDF]

JACC Basic Transl Sci, 2023
Clonal expansion refers to the proliferation and selection of advantageous "clones" that are better suited for survival in a Darwinian manner. In recent years, we have greatly enhanced our understanding of cell clonality in the cardiovascular context.
Lin A, Brittan M, Baker AH, Dimmeler S, Fisher EA, Sluimer JC, Misra A.   +6 more
europepmc   +6 more sources

Clonal expansion in normal tissues. [PDF]

Cancer Sci
AbstractCancer originates from a single ancestral cell that acquires a driver mutation, which confers a growth or survival advantage, followed by the acquisition of additional driver mutations by descendant cells. Recently, it has become evident that somatic cell mutations accumulate in normal tissues with aging and exposure to environmental factors ...
Maeda H, Kakiuchi N.
europepmc   +5 more sources

Why the HIV Reservoir Never Runs Dry: Clonal Expansion and the Characteristics of HIV-Infected Cells Challenge Strategies to Cure and Control HIV Infection

Viruses, 2021
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target proviral populations in cells that persist for prolonged periods and that can undergo clonal expansion.
Chuen-Yen Lau, Matthew A. Adan, Frank Maldarelli   +2 more
doaj   +2 more sources

The forces driving clonal expansion of the HIV-1 latent reservoir

Virology Journal, 2020
Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral load to clinically undetectable levels, viral rebound inevitably occurs once ART is interrupted.
Runxia Liu, Francesco R. Simonetti, Ya-Chi Ho   +2 more
doaj   +2 more sources

Sediment availability provokes a shift from Brownian to Lévy‐like clonal expansion in a dune building grass [PDF]

Ecology Letters, 2020
In biogeomorphic landscapes, plant traits can steer landscape development through plant‐mediated feedback interactions. Interspecific differences in clonal expansion strategy can therefore lead to the emergence of different landscape organisations.
V. Reijers, S. Hoeks, J. van Belzen, Koen Siteur, Anne J. A. de Rond, Clea N. van de Ven, C. Lammers, J. van de Koppel, T. van der Heide   +8 more
semanticscholar   +2 more sources

Clonal hematopoiesis: elements associated with clonal expansion and diseases. [PDF]

Blood Res
Abstract Clonal hematopoiesis (CH), characterized by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations, has emerged as a significant age-related phenomenon with profound implications for human health. While initially recognized in the 1960s, recent technological advances have revealed its complex nature and ...
Ryu G, Koh Y, Jaiswal S, Yoon SS.
europepmc   +3 more sources

Dynamics of latent HIV under clonal expansion.

PLoS Pathogens, 2021
The HIV latent reservoir exhibits slow decay on antiretroviral therapy (ART), impacted by homeostatic proliferation and activation. How these processes contribute to the total dynamic while also producing the observed profile of sampled latent clone ...
John M Murray
doaj   +4 more sources

The Clonal Expansion Dynamics of the HIV-1 Reservoir: Mechanisms of Integration Site-Dependent Proliferation and HIV-1 Persistence

Viruses, 2021
More than 50% of the HIV-1 latent reservoir is maintained by clonal expansion. The clonally expanded HIV-1-infected cells can contribute to persistent nonsuppressible low-level viremia and viral rebound.
Yang-Hui Jimmy Yeh, Kerui Yang, Anya Razmi, Ya-Chi Ho   +3 more
doaj   +2 more sources

Clonal Expansion of Verticillium dahliae in Lettuce [PDF]

Phytopathology®, 2014
Few studies in population biology have documented how structure and diversity of pathogens evolve over time at local scales. With the historical samples of Verticillium dahliae available from lettuce, we investigated the structure and diversity of this pathogen in time and space. Three hundred twenty-nine V.
S, Gurung, D P G, Short, Z K, Atallah, K V, Subbarao   +3 more
openaire   +3 more sources

Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans.

PLoS Pathogens, 2019
Clonal expansion of HIV infected cells plays an important role in the formation and persistence of the reservoir that allows the virus to persist, in DNA form, despite effective antiretroviral therapy. We used integration site analysis to ask if there is
Andrea L Ferris, David W Wells, Shuang Guo, Gregory Q Del Prete, Adrienne E Swanstrom, John M Coffin, Xiaolin Wu, Jeffrey D Lifson, Stephen H Hughes   +8 more
doaj   +2 more sources