Results 11 to 20 of about 95,784 (161)
Evolution of Resistance During Clonal Expansion [PDF]
Genetics, 2006 Abstract Acquired drug resistance is a major limitation for cancer therapy. Often, one genetic alteration suffices to confer resistance to an otherwise successful therapy. However, little is known about the dynamics of the emergence of resistant tumor cells.
Yoh, Iwasa +2 more
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The forces driving clonal expansion of the HIV-1 latent reservoir
Virology Journal, 2020 Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral load to clinically undetectable levels, viral rebound inevitably occurs once ART is interrupted.
Runxia Liu +2 more
doaj +1 more source
Novel synthetic monoketone transmute radiation-triggered NFκB-dependent TNFα cross-signaling feedback maintained NFκB and favors neuroblastoma regression. [PDF]
PLoS ONE, 2013 Recently, we demonstrated that radiation (IR) instigates the occurrence of a NFκB-TNFα feedback cycle which sustains persistent NFκB activation in neuroblastoma (NB) cells and favors survival advantage and clonal expansion.
Sheeja Aravindan +4 more
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Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs. [PDF]
PLoS Genetics, 2018 Postzygotic single-nucleotide mosaicisms (pSNMs) have been extensively studied in tumors and are known to play critical roles in tumorigenesis. However, the patterns and origin of pSNMs in normal organs of healthy humans remain largely unknown.
August Yue Huang +6 more
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Many colorectal cancers are “flat” clonal expansions [PDF]
Cell Cycle, 2009 Population geneticists can reconstruct the ancestries of macroscopic populations from polymorphisms in present day individuals. For example, the migration "out of Africa" is recorded in human genome variation in different parts of the world. Here we apply this approach to human colorectal cancer cell populations and polymorphic passenger methylation ...
Kimberly D, Siegmund +3 more
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Clonal expansion behind a marine diatom bloom [PDF]
The ISME Journal, 2017 Abstract Genetic diversity is what selection acts on, thus shaping the adaptive potential of populations. We studied micro-evolutionary patterns of the key planktonic diatom Pseudo-nitzschia multistriata at a long-term sampling site over 2 consecutive years by genotyping isolates with 22 microsatellite markers.
Maria Valeria Ruggiero +6 more
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Effects of Cu Pollution on the Expansion of an Amphibious Clonal Herb in Aquatic-Terrestrial Ecotones. [PDF]
PLoS ONE, 2016 Physiological integration can enhance the performance of clonal plants in aquatic and terrestrial heterogeneous habitats and associated ecotones. Similar to nutrients, pollutants may be transported among connected ramets via physiological integration ...
Liang Xu, Zhen-Feng Zhou
doaj +1 more source
iScience, 2023 Summary: SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster.
Ellie N. Ivanova +20 more
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Analysis of TET2 mutations in paroxysmal nocturnal hemoglobinuria (PNH)
Experimental Hematology & Oncology, 2019 Background Large clonal populations of cells bearing PIG-A mutations are the sine qua non of PNH, but the PIG-A mutation itself is insufficient for clonal expansion.
Camille Lobry +5 more
doaj +1 more source
Bayesian Inference of Clonal Expansions in a Dated Phylogeny [PDF]
Systematic Biology, 2021 Abstract Microbial population genetics models often assume that all lineages are constrained by the same population size dynamics over time. However, many neutral and selective events can invalidate this assumption and can contribute to the clonal expansion of a specific lineage relative to the rest of the population.
David Helekal +4 more
openaire +3 more sources