Clonal expansion behind a marine diatom bloom [PDF]
The ISME Journal, 2017 Abstract Genetic diversity is what selection acts on, thus shaping the adaptive potential of populations. We studied micro-evolutionary patterns of the key planktonic diatom Pseudo-nitzschia multistriata at a long-term sampling site over 2 consecutive years by genotyping isolates with 22 microsatellite markers.
Maria Valeria Ruggiero +6 more
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Cerebral Cavernous Malformations Develop through Clonal Expansion of Mutant Endothelial Cells [PDF]
bioRxiv, 2018 Rationale Vascular malformations arise in vessels throughout the entire body. Causative genetic mutations have been identified for many of these diseases; however, little is known about the mutant cell lineage within these malformations.
M. Detter, D. Snellings, D. Marchuk
semanticscholar +2 more sources
Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells [PDF]
Genome BiologyBackground Mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, but their efficacy as reliable lineage markers are hindered by the complex dynamics of mtDNA in somatic tissues.
Xin Wang +11 more
doaj +2 more sources
Select sequencing of clonally expanded CD8+T cells reveals limits to clonal expansion [PDF]
Proceedings of the National Academy of Sciences, 2019 To permit the recognition of antigens, T cells generate a vast diversity of T cell receptor (TCR) sequences. Upon binding of the TCR to an antigen–MHC complex, T cells clonally expand to establish an immune response. To study antigen-specific T cell clonality, we have developed a method that allows selection of rare cells, based on RNA expression ...
Huang Huang +7 more
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Typical Rhizomatous Clonal Grass Psammochloa villosa Changes Resource Allocation During Clonal Expansion to Fit Arid Sandy Habitats [PDF]
Ecology and EvolutionRhizomatous plants forming patchy expansions show high potential for sand fixation in mobile dunes with heterogeneous resources, yet resource allocation strategies among different plant parts and reproductive methods during patch expansion remain poorly ...
Heng Ren +4 more
doaj +2 more sources
Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium. [PDF]
Cell Reports, 2018 K. Suda +14 more
semanticscholar +2 more sources
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
Nature Genetics, 2023 NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this hypothesis.
E. Abby +12 more
semanticscholar +1 more source
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory
Nature Immunology, 2022 Clonal expansion of cells with somatically diversified receptors and their long-term maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied pathogen-specific adaptation within the innate immune system, tracking natural killer ...
T. Rückert +4 more
semanticscholar +1 more source
EBioMedicine, 2022 Summary: Background: Severe COVID-19 T-cell lymphopenia is more common among older adults and entails poor prognosis. Offsetting the decline in T-cell count during COVID-19 demands fast and massive T-cell clonal expansion, which is telomere length (TL ...
James J. Anderson +6 more
doaj +1 more source
Using DNA methylation patterns to infer tumor ancestry. [PDF]
PLoS ONE, 2010 Exactly how human tumors grow is uncertain because serial observations are impractical. One approach to reconstruct the histories of individual human cancers is to analyze the current genomic variation between its cells.
You Jin Hong +3 more
doaj +1 more source