Results 271 to 280 of about 2,119,256 (322)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Variation in cancer risk between organs can not be explained by the degree of somatic clonal expansion. [PDF]

Adv Biotechnol (Singap)
Zhang D, Zhang A, He X, Deng S.
europepmc   +1 more source

Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru

, 2014
Marco Galarza, David Tarazona, Víctor Borda, Juan Agapito, Heinner Guio   +4 more
openalex   +1 more source

Gallium‐Doped MXene Nanozymes Protect Liver Through Multi‐Death Pathway Blockade and Hepatocyte Regeneration

Advanced Science, EarlyView.
This study develops gallium‐doped V2C MXene nanozymes (Ga‐V2C) to treat acetaminophen‐induced liver injury through multi‐death pathway blockade and hepatocyte regeneration. Unlike conventional single‐target therapies like N‐acetylcysteine, Ga‐V2C nanozymes enable oxidative stress suppression, apoptosis, and ferroptosis inhibition, and enhanced ...
Xiaopeng Cai, Jingwen Deng, Liqing Wang, Junjie Su, Dongyi Xian, Yilang Yan, Xinyu Yang, Chuanbin Wu, Tingting Peng, Yuan Ding, Guilan Quan, Weilin Wang, Min Zhou, Chao Lu   +13 more
wiley   +1 more source

Genetic markers associated with host status and clonal expansion of Group B Streptococcus in the Netherlands. [PDF]

Front Microbiol
Khan UB, Dyster V, Chaguza C, van Sorge NM, van de Beek D, Man WK, Bentley SD, Bijlsma MW, Jamrozy D.   +8 more
europepmc   +1 more source

A GLUTAMATE CYSTEINE LIGASE Gene StGSH1 Regulated by StERF10 Enhanced Glutathione Accumulation and Adaptation to Low Phosphorus Stress in Potato

Advanced Science, EarlyView.
The StERF10‐StGSH1 module coordinates glutathione (GSH) biosynthesis under low‐phosphorus stress. The low‐phosphate‐induced AP2/ERF transcription factor StERF10 directly activates the transcription of StGSH1 and enhances GSH accumulation. Consequently, GSH scavenges reactive oxygen species and provides sulfur for sulfolipid synthesis, facilitating the ...
Xiaocheng Tian, Mingjun Li, Xiaojia Huang, Markus Wirtz, Xiaohui Zheng, Shilong Fan, Jiang Tian, Shaoqun Liu, Zhonghua Liu, Hongbo Zhao   +9 more
wiley   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Methicillin-resistant <i>Staphylococcus aureus</i> in Saudi Arabia: genomic evidence of recent clonal expansion and plasmid-driven resistance dissemination.

Front Microbiol
Alhejaili AY, Zhou G, Halawa H, Huang J, Fallatah O, Hirayban R, Iftikhar S, AlAsmari A, Milner M, Banzhaf M, Alzaidi AA, Rajeh AA, Al-Otaiby MA, Alabbad SS, Bukhari D, Aljurayyan AN, Aljasham AT, Alzeyadi ZA, Alajel SM, Alanazi RH, Alghoribi M, Almutairi MM, Pain A, Senok A, Moradigaravand D, Al Salem W.   +25 more
europepmc   +1 more source

Multiplex gene editing models of del(7q) reveal combined <i>CUX1</i> and <i>EZH2</i> loss drives clonal expansion and drug resistance. [PDF]

Blood Neoplasia
Jotte MRM, Stoddart A, Martinez TC, Moten R, Xue Y, Imgruet MK, Blaylock H, Nam HS, Hu B, Austin J, An N, Khan S, Gurbuxani SK, McNerney ME.   +13 more
europepmc   +1 more source