Results 21 to 30 of about 2,119,256 (322)

Emerging Concepts of Vascular Cell Clonal Expansion in Atherosclerosis

Arteriosclerosis, Thrombosis and Vascular Biology, 2022
Clonal expansion is a process that can drive pathogenesis in human diseases, with atherosclerosis being a prominent example. Despite advances in understanding the etiology of atherosclerosis, clonality studies of vascular cells remain in an early stage ...
A. Misra, Rajan Rehan, A. Lin, Sanjay Patel, E. Fisher   +4 more
semanticscholar   +1 more source

Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer

Nature Cancer, 2021
Anti-PD-1 treatment has shown unprecedented clinical success in the treatment of non-small-cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood.
Baolin Liu, Xueda Hu, K. Feng, Ranran Gao, Zhiqiang Xue, Su-jie Zhang, Yuanyuan Zhang, E. Corse, Yi Hu, W. Han, Zemin Zhang   +10 more
semanticscholar   +1 more source

Clonal expansion and activation of tissue-resident memory-like TH17 cells expressing GM-CSF in the lungs of patients with severe COVID-19

Science immunology, 2021
Tissue-resident memory-like Th17 are clonally expanded in bronchoalveolar lavage fluid of severe COVID-19 patients. Hyperinflammation contributes to lung injury and subsequent acute respiratory distress syndrome (ARDS) with high mortality in patients ...
Yu Zhao, Christoph Kilian, J. Turner, L. Bosurgi, K. Roedl, P. Bartsch, Ann-Christin Gnirck, F. Cortesi, C. Schultheiss, Malte Hellmig, Leon U. B. Enk, Fabian Hausmann, Alina Borchers, M. N. Wong, H. Paust, Francesco Siracusa, Nicola Scheibel, Marissa Herrmann, E. Rosati, P. Bacher, Dominik Kylies, D. Jarczak, M. Lütgehetmann, S. Pfefferle, S. Steurer, Julian Schulze Zur-Wiesch, Victor G. Puelles, J. Sperhake, M. Addo, A. Lohse, M. Binder, S. Huber, T. Huber, S. Kluge, Stefan Bonn, U. Panzer, N. Gagliani, C. Krebs   +37 more
semanticscholar   +1 more source

Genetic instability and clonal expansion [PDF]

Journal of Theoretical Biology, 2006
Inactivation of tumor suppressor genes can lead to clonal expansion. We study the evolutionary dynamics of this process and calculate the probability that inactivation of a tumor suppressor gene is preceded by mutations in genes that confer genetic instability.
Nowak, Martin A., Michor, Franziska, Iwasa, Yoh   +2 more
openaire   +2 more sources

A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

iScience, 2023
Summary: Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells (ECs), and one potential origin is clonal selection.
Aneel R. Bhagwani, Mehboob Ali, Bryce Piper, Mingjun Liu, Jaylen Hudson, Neil Kelly, Srimathi Bogamuwa, Hu Yang, James D. Londino, Joseph S. Bednash, Daniela Farkas, Rama K. Mallampalli, Mark R. Nicolls, John J. Ryan, A.A. Roger Thompson, Stephen Y. Chan, Delphine Gomez, Elena A. Goncharova, Laszlo Farkas   +18 more
doaj   +1 more source

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

Nature Medicine, 2020
Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa1–4. Here we genotyped the P.
A. Uwimana, E. Legrand, Barbara H. Stokes, Jean-Louis Mangala Ndikumana, M. Warsame, Noella Umulisa, D. Ngamije, Tharcisse Munyaneza, J. Mazarati, Kaendi J. Munguti, P. Campagne, A. Criscuolo, F. Ariey, Monique Murindahabi, P. Ringwald, D. Fidock, A. Mbituyumuremyi, D. Ménard   +17 more
semanticscholar   +1 more source

CD4⁺CD8α^low T Cell Clonal Expansion Dependent on Costimulation in Patients With Rheumatoid Arthritis. [PDF]

Arthritis Rheumatol
Beck F, Nguyen P, Hoffmann A, Loyal L, Thiel A, Melzer M, Apel H, Pierer M, Krasselt M, Seifert O, Glimm AM, Hagemann T, Rothe K, Wagner U.   +13 more
europepmc   +3 more sources

Evolution of Resistance During Clonal Expansion [PDF]

Genetics, 2006
Abstract Acquired drug resistance is a major limitation for cancer therapy. Often, one genetic alteration suffices to confer resistance to an otherwise successful therapy. However, little is known about the dynamics of the emergence of resistant tumor cells.
Yoh, Iwasa, Martin A, Nowak, Franziska, Michor   +2 more
openaire   +2 more sources

Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium. [PDF]

Nat Genet
Herms A, Fernandez-Antoran D, Alcolea MP, Kalogeropoulou A, Banerjee U, Piedrafita G, Abby E, Valverde-Lopez JA, Ferreira IS, Caseda I, Bejar MT, Dentro SC, Vidal-Notari S, Ong SH, Colom B, Murai K, King C, Mahbubani K, Saeb-Parsy K, Lowe AR, Gerstung M, Jones PH.   +21 more
europepmc   +2 more sources

Novel synthetic monoketone transmute radiation-triggered NFκB-dependent TNFα cross-signaling feedback maintained NFκB and favors neuroblastoma regression. [PDF]

PLoS ONE, 2013
Recently, we demonstrated that radiation (IR) instigates the occurrence of a NFκB-TNFα feedback cycle which sustains persistent NFκB activation in neuroblastoma (NB) cells and favors survival advantage and clonal expansion.
Sheeja Aravindan, Mohan Natarajan, Vibhudutta Awasthi, Terence S Herman, Natarajan Aravindan   +4 more
doaj   +1 more source