Results 21 to 30 of about 95,784 (161)
Computational identification of clonal cells in single-cell CRISPR screens
BMC Genomics, 2022 Background Single-cell CRISPR screens are powerful tools to understand genome function by linking genetic perturbations to transcriptome-wide phenotypes.
Yihan Wang +3 more
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Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential
Nature Communications, 2018 Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones.
Terrence N. Wong +21 more
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Frontiers in Plant Science, 2019 Clonal traits can contribute to plant invasiveness, but little is known about the roles of division of labor (a key clonal trait) in homogeneous habitats. The hypothesis tested is that clonal integration allows division of labor and increases the overall
Dao-Guo Xi +4 more
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Flower-deficient mice have reduced susceptibility to skin papilloma formation
Disease Models & Mechanisms, 2012 SUMMARY Skin papillomas arise as a result of clonal expansion of mutant cells. It has been proposed that the expansion of pretumoral cell clones is propelled not only by the increased proliferation capacity of mutant cells, but also by active cell ...
Evgeniya Petrova +3 more
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JunB Is Critical for Survival of T Helper Cells
Frontiers in Immunology, 2022 Clonal expansion and differentiation of various T helper subsets, such as Th1, Th2, and Th17 cells, depend on a complex of transcription factors, IRF4 and a BATF-containing AP-1 heterodimer.
Tsunghan Hsieh +7 more
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Haematologica, 2023 Clonal expansion of CD5-expressing B cells, commonly designated as monoclonal B lymphocytosis (MBL), is a precursor condition for chronic lymphocytic leukemia (CLL).
Edwin Quinten +20 more
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The evolution of tumor metastases during clonal expansion [PDF]
Journal of Theoretical Biology, 2010 Cancer is a leading cause of morbidity and mortality in many countries. Solid tumors generally initiate at one particular site called the primary tumor, but eventually disseminate and form new colonies in other organs. The development of such metastases greatly diminishes the potential for a cure of patients and is thought to represent the final stage ...
Haeno, Hiroshi, Michor, Franziska
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The Evolution of Two Mutations During Clonal Expansion [PDF]
Genetics, 2007 Abstract Knudson's two-hit hypothesis proposes that two genetic changes in the RB1 gene are the rate-limiting steps of retinoblastoma. In the inherited form of this childhood eye cancer, only one mutation emerges during somatic cell divisions while in sporadic cases, both alleles of RB1 are inactivated in the growing retina.
Hiroshi, Haeno +2 more
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Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model
Scientific Reports, 2017 Combination anti-retroviral therapy (cART) has drastically improved the clinical outcome of HIV-1 infection. Nonetheless, despite effective cART, HIV-1 persists indefinitely in infected individuals.
Yorifumi Satou +12 more
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Determinants of mosaic chromosomal alteration fitness
Nature CommunicationsClonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural ...
Yash Pershad +43 more
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