Results 41 to 50 of about 95,784 (161)
Protocol for monitoring clonal hematopoiesis in transgenic mouse models using multispectral imaging
STAR ProtocolsSummary: Clonal hematopoiesis involves the clonal expansion of hematopoietic cells, potentially progressing into hematological malignancies. Here, we present a protocol for the development and characterization of two mouse models designed to simulate ...
Priyanka Khanna +5 more
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The role of host environment in cancer evolution
Evolutionary Applications, 2020 Somatic mutations in oncogene and tumor suppressor genes accumulate in healthy tissues throughout life and delineate clones with limited expansion. Lifestyle‐related toxic insults increase the size and number of these clones that participate to tissue ...
Eric Solary, Lucie Laplane
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Select sequencing of clonally expanded CD8+T cells reveals limits to clonal expansion [PDF]
Proceedings of the National Academy of Sciences, 2019 To permit the recognition of antigens, T cells generate a vast diversity of T cell receptor (TCR) sequences. Upon binding of the TCR to an antigen–MHC complex, T cells clonally expand to establish an immune response. To study antigen-specific T cell clonality, we have developed a method that allows selection of rare cells, based on RNA expression ...
Huang Huang +7 more
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Abstract 2675: Clonal expansion of skin keratinocyte
Cancer Research, 2021 Abstract Skin is the largest organ system and is exposed to ultraviolet (UV) or sun light, a well-known mutagenic insult in various skin cancers, depending on the body site. A previous study showed that keratinocytes in sun-exposed eyelids harbor a high number of somatic mutations affecting a number of common driver mutations found in ...
Yoshihiro Ishida +14 more
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Biología de la expansión clonal
Iatreia, 2006 La expansión clonal-subclonal, tanto in vivo como in vitro, se caracteriza por la ventaja proliferativa de sub-poblaciones celulares subyacentes.
M. Soto, M. Camargo
doaj
Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium
Nature Communications, 2022 Through regeneration, the endometrium accumulates somatic mutations that can lead to diseases like endometriosis and cancer. Here, the authors use genomics to analyse normal endometrial glands from different patient cohorts, detect rhizome structures ...
Manako Yamaguchi +17 more
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Consequences of clonality for sexual fitness: Clonal expansion enhances fitness under spatially restricted dispersal [PDF]
Proceedings of the National Academy of Sciences, 2015 Clonality is a pervasive feature of sessile organisms, but this form of asexual reproduction is thought to interfere with sexual fitness via the movement of gametes among the modules that comprise the clone. This within-clone movement of gametes is expected to reduce sexual fitness via mate limitation of male reproductive success and, in some cases ...
Van Drunen, Wendy E. +2 more
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npj Breast CancerPatients with germline pathogenic variants of BRCA1/2 genes have a particular predisposition to develop breast cancer. No clinical test has been developed to accurately and quantitatively evaluate their risk of developing breast cancer.
Takeshi Hirose +12 more
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SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion
Cell Reports, 2017 Preadipocytes initiate differentiation into adipocytes through a cascade of events. Mitotic clonal expansion, as one of the earliest events, is essential for adipogenesis.
Qiang Chen +7 more
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T Cell Clonal Analysis Using Single-cell RNA Sequencing and Reference Maps
Bio-Protocol, 2023 T cells are endowed with T-cell antigen receptors (TCR) that give them the capacity to recognize specific antigens and mount antigen-specific adaptive immune responses.
Massimo Andreatta +3 more
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