Results 41 to 50 of about 2,119,256 (322)
Nature Communications, 2020 HIV viremia can be controlled by chronic antiretroviral therapy. As a potentially single-shot alternative, B cells engineered by CRISPR/Cas9 to express anti-HIV broadly neutralizing antibodies (bNAbs) are capable of secreting high antibody titers.
A. Nahmad +11 more
semanticscholar +1 more source
Flower-deficient mice have reduced susceptibility to skin papilloma formation
Disease Models & Mechanisms, 2012 SUMMARY Skin papillomas arise as a result of clonal expansion of mutant cells. It has been proposed that the expansion of pretumoral cell clones is propelled not only by the increased proliferation capacity of mutant cells, but also by active cell ...
Evgeniya Petrova +3 more
doaj +1 more source
JunB Is Critical for Survival of T Helper Cells
Frontiers in Immunology, 2022 Clonal expansion and differentiation of various T helper subsets, such as Th1, Th2, and Th17 cells, depend on a complex of transcription factors, IRF4 and a BATF-containing AP-1 heterodimer.
Tsunghan Hsieh +7 more
doaj +1 more source
Haematologica, 2023 Clonal expansion of CD5-expressing B cells, commonly designated as monoclonal B lymphocytosis (MBL), is a precursor condition for chronic lymphocytic leukemia (CLL).
Edwin Quinten +20 more
doaj +1 more source
Nature Communications, 2019 After initiating antiretroviral therapy (ART), a rapid decline in HIV viral load is followed by a long period of undetectable viremia. Viral outgrowth assay suggests the reservoir continues to decline slowly.
M. Pinzone +16 more
semanticscholar +1 more source
Isoeugenol Inhibits Adipogenesis in 3T3-L1 Preadipocytes with Impaired Mitotic Clonal Expansion. [PDF]
NutrientsChoi YR, Na HJ, Lee J, Kim YS, Kim MJ.
europepmc +3 more sources
The evolution of tumor metastases during clonal expansion [PDF]
Journal of Theoretical Biology, 2010 Cancer is a leading cause of morbidity and mortality in many countries. Solid tumors generally initiate at one particular site called the primary tumor, but eventually disseminate and form new colonies in other organs. The development of such metastases greatly diminishes the potential for a cure of patients and is thought to represent the final stage ...
Haeno, Hiroshi, Michor, Franziska
openaire +3 more sources
Endothelial cell clonal expansion in the development of cerebral cavernous malformations
Nature Communications, 2019 Cerebral cavernous malformation (CCM) is a neurovascular familial or sporadic disease that is characterised by capillary-venous cavernomas, and is due to loss-of-function mutations to any one of three CCM genes.
M. Malinverno +14 more
semanticscholar +1 more source
Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model
Scientific Reports, 2017 Combination anti-retroviral therapy (cART) has drastically improved the clinical outcome of HIV-1 infection. Nonetheless, despite effective cART, HIV-1 persists indefinitely in infected individuals.
Yorifumi Satou +12 more
doaj +1 more source
The Evolution of Two Mutations During Clonal Expansion [PDF]
Genetics, 2007 Abstract Knudson's two-hit hypothesis proposes that two genetic changes in the RB1 gene are the rate-limiting steps of retinoblastoma. In the inherited form of this childhood eye cancer, only one mutation emerges during somatic cell divisions while in sporadic cases, both alleles of RB1 are inactivated in the growing retina.
Hiroshi, Haeno +2 more
openaire +2 more sources