Results 51 to 60 of about 2,119,256 (322)

Insights Into the Emergence of Paroxysmal Nocturnal Hemoglobinuria

Frontiers in Immunology, 2022
Paroxysmal Nocturnal Hemoglobinuria (PNH) is a disease as simple as it is complex. PNH patients develop somatic loss-of-function mutations in phosphatidylinositol N-acetylglucosaminyltransferase subunit A gene (PIGA), required for the biosynthesis of ...
Melissa A. Colden, Melissa A. Colden, Sushant Kumar, Sushant Kumar, Bolormaa Munkhbileg, Bolormaa Munkhbileg, Daria V. Babushok, Daria V. Babushok   +7 more
doaj   +1 more source

The rise and rise of mitochondrial DNA mutations [PDF]

Open Biology, 2020
How mitochondrial DNA mutations clonally expand in an individual cell is a question that has perplexed mitochondrial biologists for decades. A growing body of literature indicates that mitochondrial DNA mutations play a major role in ageing, metabolic ...
Conor Lawless, Laura Greaves, Amy K. Reeve, Doug M. Turnbull, Amy E. Vincent   +4 more
doaj   +1 more source

Determinants of mosaic chromosomal alteration fitness

Nature Communications
Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural ...
Yash Pershad, Taralynn Mack, Hannah Poisner, Yasminka A. Jakubek, Adrienne M. Stilp, Braxton D. Mitchell, Joshua P. Lewis, Eric Boerwinkle, Ruth J. F. Loos, Nathalie Chami, Zhe Wang, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M. Psaty, Joshua C. Bis, Ali Shojaie, Edwin K. Silverman, Michael H. Cho, Jeong H. Yun, Dawn DeMeo, Daniel Levy, Andrew D. Johnson, Rasika A. Mathias, Margaret A. Taub, Donna Arnett, Kari E. North, Laura M. Raffield, April P. Carson, Margaret F. Doyle, Stephen S. Rich, Jerome I. Rotter, Xiuqing Guo, Nancy J. Cox, Dan M. Roden, Nora Franceschini, Pinkal Desai, Alex P. Reiner, Paul L. Auer, Paul A. Scheet, Siddhartha Jaiswal, Joshua S. Weinstock, Alexander G. Bick   +43 more
doaj   +1 more source

FTO influences adipogenesis by regulating mitotic clonal expansion [PDF]

Nature Communications, 2015
AbstractThe fat mass and obesity-associated (FTO) gene plays a pivotal role in regulating body weight and fat mass; however, the underlying mechanisms are poorly understood. Here we show that primary adipocytes and mouse embryonic fibroblasts (MEFs) derived from FTO overexpression (FTO-4) mice exhibit increased potential for adipogenic differentiation,
Merkestein, Myrte, Laber, Samantha, McMurray, Fiona, Andrew, Daniel, Gregor, Sachse, Sanderson, Jeremy, Li, Mengdi, Usher, Samuel, Sellayah, Dyan, Ashcroft, Frances M., Cox, Roger D.   +10 more
openaire   +3 more sources

Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy.

Blood Advances, 2019
Reexpansion of CAR T cells led to further investigations which confirmed the clonal nature of this expansion.
N. Shah, Haiying Qin, B. Yates, Ling Su, Haneen Shalabi, M. Raffeld, M. Ahlman, M. Stetler-Stevenson, C. Yuan, Shuang Guo, Siyuan Liu, S. Hughes, T. Fry, Xiaolin Wu   +13 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Clonal expansion of T-cells in measles

Immunology Letters, 1998
Some autoimmune complications such as postinfectious encephalomyelitis are associated with immunologic abnormalities induced by measles virus infection. To address the superantigenic stimulation in measles which might be related with autoimmune complications, T-cells bearing the TCRBV5S2 or TCRBV8 chains and the expression of activation markers were ...
Chwae, YJ, Choi, IH, Kim, DS, Shin, EC Shin, Eui-Cheol, Kwon, DH, Kim, SJ, Kim, JD   +6 more
openaire   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Soil saline-alkali heterogeneity is an important factor driving the spatial expansion of clonal plant in grassland

Frontiers in Environmental Science, 2023
Soil salinity is well known heterogeneous and various within natural soil environment. In Songnen grassland of Northeast China, grazing aggravates the saline-alkali heterogeneity in soil habitat, which led to dominant clonal plant species forming a ...
Luhao Qu, Jun Liu, Jun Liu, Jiyun Yang, Long Bai, Yue Huang, Nan Lu, Hongzhu Yu, Zhifeng Wang, Zhonghe Li   +9 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source