Results 51 to 60 of about 95,784 (161)

A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions

Nature Communications
Effective cancer immunotherapy relies on the clonal proliferation and expansion of CD8+ T cells in the tumor. However, our insights into clonal expansions are limited, owing to an inability to track the same clones in tumors over time. Here, we develop a
Munetomo Takahashi, Mikiya Tsunoda, Hiroyasu Aoki, Masaki Kurosu, Haru Ogiwara, Shigeyuki Shichino, David Bending, Shumpei Ishikawa, James E. D. Thaventhiran, Kouji Matsushima, Satoshi Ueha   +10 more
doaj   +1 more source

Stem cell graft dose and composition could impact on the expansion of donor-derived clones after allogeneic hematopoietic stem cell transplantation – a virtual clinical trial

Frontiers in Immunology
IntroductionHematopoietic stem cell transplantation is a potentially curative intervention for a broad range of diseases. However, there is evidence that malignant or pre-malignant clones contained in the transplant can expand in the recipient and ...
Thomas Stiehl, Thomas Stiehl
doaj   +1 more source

Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans.

PLoS Pathogens, 2019
Clonal expansion of HIV infected cells plays an important role in the formation and persistence of the reservoir that allows the virus to persist, in DNA form, despite effective antiretroviral therapy. We used integration site analysis to ask if there is
Andrea L Ferris, David W Wells, Shuang Guo, Gregory Q Del Prete, Adrienne E Swanstrom, John M Coffin, Xiaolin Wu, Jeffrey D Lifson, Stephen H Hughes   +8 more
doaj   +1 more source

Clonal Expansion  without Self-replicating Entities [PDF]

, 2012
The vertebrate immune system is a complex distributed system capable of learning to tolerate the organisms' tissues, to assimilate a diverse commensal microflora, and to mount specific responses to invading pathogens. These intricate functions are performed almost flawlessly by a self-organised collective of cells.
Danesh Tarapore, Anders Lyhne Christensen, Pedro U. Lima, Jorge Carneiro   +3 more
openaire   +1 more source

Integron-mediated Multidrug Resistance in a Global Collection of Nontyphoidal Salmonella enterica Isolates

Emerging Infectious Diseases, 2009
Salmonella enterica bacteria have become increasingly resistant to antimicrobial agents, partly as a result of genes carried on integrons. Clonal expansion and horizontal gene transfer may contribute to the spread of antimicrobial drug–resistance ...
Mary G. Krauland, Jane W. Marsh, David L. Paterson, Lee H. Harrison   +3 more
doaj   +1 more source

Somatic mutation and clonal expansions in human tissues [PDF]

Genome Medicine, 2019
Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for our understanding of cancer, ageing, and other diseases.
openaire   +3 more sources

Small-Sized Clone of T Cells in Multiple Myeloma Patient after Auto-SCT: T-LGL Leukemia Type or Clonal T-Cell Aberration?

Case Reports in Hematology, 2013
Second cancers and particularly postransplant lymphoproliferative disorders (PTLDs) are extremely rare in patients undergoing autologous peripheral blood stem cell transplantation (auto-SCT).
Giuseppe Mele, Marilena Greco, Maria Rosaria Coppi, Giacomo Loseto, Angela Melpignano, Salvatore Mauro, Gianni Quarta   +6 more
doaj   +1 more source

Systems Analysis Reveals High Genetic and Antigen-Driven Predetermination of Antibody Repertoires throughout B Cell Development

Cell Reports, 2017
Antibody repertoire diversity and plasticity is crucial for broad protective immunity. Repertoires change in size and diversity across multiple B cell developmental stages and in response to antigen exposure.
Victor Greiff, Ulrike Menzel, Enkelejda Miho, Cédric Weber, René Riedel, Skylar Cook, Atijeh Valai, Telma Lopes, Andreas Radbruch, Thomas H. Winkler, Sai T. Reddy   +10 more
doaj   +1 more source

Limiting Dilution & Clonal Expansion v1 [PDF]

, 2018
CRISPR-Cas9 can be used to generate edited cell pools for a variety of applications. These pools contain a heterogeneous mix of cells, some unedited and some with different genetic alterations at the targeted locus. In order to produce a cell line with a particular edit or knockout, clonal expansion of individual cells is necessary.
openaire   +1 more source

The Impact of Splicing Factor Mutations on Clonal Hematopoiesis and Myeloid Neoplasm Progression

Frontiers in Bioscience-Landmark
Clonal hematopoiesis (CH) is characterized by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations, which confers an increased risk of hematologic malignancies and cardiovascular disease.
Takuya Izumi-Tamura, Asuka Kawachi, Akihide Yoshimi   +2 more
doaj   +1 more source