Results 101 to 110 of about 102,010 (264)

Inferring clonal structure in HTLV-1-infected individuals: towards bridging the gap between analysis and visualization

Human Genomics, 2017
Background Human T cell leukemia virus type 1 (HTLV-1) causes adult T cell leukemia (ATL) in a proportion of infected individuals after a long latency period.
Amir Farmanbar, Sanaz Firouzi, Wojciech Makałowski, Masako Iwanaga, Kaoru Uchimaru, Atae Utsunomiya, Toshiki Watanabe, Kenta Nakai   +7 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

The forces driving clonal expansion of the HIV-1 latent reservoir

Virology Journal, 2020
Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral load to clinically undetectable levels, viral rebound inevitably occurs once ART is interrupted.
Runxia Liu, Francesco R. Simonetti, Ya-Chi Ho   +2 more
doaj   +1 more source

Modeling viral coevolution: HIV multi-clonal persistence and competition dynamics [PDF]

, 2005
The coexistence of different viral strains (quasispecies) within the same host are nowadays observed for a growing number of viruses, most notably HIV, Marburg and Ebola, but the conditions for the formation and survival of new strains have not yet been ...
Altfeld, Bagnoli, Bello, Blackard, Burch, Celada, Chao, Costa, De Boer, De Boer, Eigen, Eigen, F. Bagnoli, Franz, Galvani, Gerhardt, Gog, Haaft, Ho, Jenkins, Jetzt, Kijak, Krempl, L. Sguanci, Levy, Lin, Lio, Mansky, Miller, Neumann, P. Liò, Pantaleo, Parkin, Perelson, Perelson, Ramos, Revilla, Schnell, Shankarappa, Wei, Wiegel, Wodarz1, Yang, Zanotto   +43 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Effects of clonal integration on the proximal and distal ramets of Cynodon dactylon under shade stress

Brazilian Archives of Biology and Technology, 2018
In a pot experiment, clonal ramets of Cynodon dactylon, a stolon herbaceous plant, were treated with heterogeneous lighting. Proximal ramets (elder ramets) were subjected to shade stress at three different degrees, and stolons between proximal and distal
Tao Ying Shi, Qiu-Mei Quan, Yun-Xiang Li
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Timing of systemic resistance induced by local exogenous ABA application within clonal network of stoloniferous herb Centella asiatica subjected to low water availability

Frontiers in Plant Science
Resistance traits of plants can be activated both at the damaged site and undamaged parts. Systemic resistance induced by local exogenous abscisic acid (ABA) application alleviated negative effect of low water availability on growth performance of clonal
Su-Juan Duan, Su-Juan Duan, Gui-Jia Sun, Yi Dan, Jie Deng, Dong-Wei Yu, Qin Wei, Chang-Fan Chen, Jie Jiang, Xue-Mei Wang, Ting-Ju Ren, Yong-Mei Liao, Jin-Song Chen   +12 more
doaj   +1 more source

Hitchhiking Trypanosoma cruzi minicircle DNA affects gene expression in human host cells via LINE-1 retrotransposon [PDF]

, 2006
The horizontal transfer of Trypanosoma cruzi mitochondrial minicircle DNA to the genomes of naturally infected humans may play an important role in the pathogenesis of Chagas disease.
Alves, Nivaldo Pereira, Argañaraz, Enrique Roberto, Barbosa, Augusto Mello Simões, Costa, Ana Maria, D'Souza-Ault, Marian, Louvandini, Patricia, Nascimento, Rubens José do, Nitz, Nadjar, Rosa, Ana de Cassia Oliveira Cardoso, Sturm, Nancy R., Teixeira, Antonio Raimundo Lima Cruz   +10 more
core   +3 more sources