Results 81 to 90 of about 3,220,233 (234)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Nature Communications, 2020 Understanding factors that impact CAR T cell expansion in the clinic is crucial to improving its therapeutic success. Here the authors document heterogeneity in the clonal dynamics of CAR-T cells by tracking individual clones using the endogenous TCR and
Alyssa Sheih +16 more
doaj +1 more source
Clonal integration of Agrostis stolonifera in heterogeneous soil environment [PDF]
, 2014 Clonal plants may be able to cope with spatial heterogeneity due to the physiological integration of ramets. Previous studies demonstrated that benefits of clonal integration increase with patch contrast between individual ramets.
Duchoslavová, Jana
core
Shorterm fitness benefits of physiological integration in the clonal herb hydrocotyle peduncularis
, 2015 We test whether physiological integration enhances the short-term fitness of the clonal herb Hydrocotyle peduncularis (Apiaceae, R. Brown ex A. Richards) subjected to spatial variation in water availability.
Peterson, Vicki, Chesson, Peter
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
PLoS ONE, 2014 Through physiological integration, clonal plants can support ramets in unfavourable patches, exploit heterogeneously distributed resources and distribute resources that are taken up over large areas.
Tina D'Hertefeldt +2 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
PLoS Pathogens, 2019 Clonal expansion of HIV infected cells plays an important role in the formation and persistence of the reservoir that allows the virus to persist, in DNA form, despite effective antiretroviral therapy. We used integration site analysis to ask if there is
Andrea L Ferris +8 more
doaj +1 more source
, 2018 : Exploring the mechanism of plant species persistence in fragmented landscapes has already become a major issue in spatial ecology. Most of previous models predicted that habitat loss and fragmentation negatively impact plant species persistence, while ...
Ying, Zhixia, Ge, Gang, Liu, Yongjie
core +1 more source