Results 71 to 80 of about 102,191 (285)
Viruses, 2021 More than 50% of the HIV-1 latent reservoir is maintained by clonal expansion. The clonally expanded HIV-1-infected cells can contribute to persistent nonsuppressible low-level viremia and viral rebound.
Yang-Hui Jimmy Yeh +3 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Clonal integration effects in the coastal systems invasions by Carpobrotus edulis: a field experiment [PDF]
, 2018 [Resumo]: As especies invasoras son das principais causas da perda de biodiversidade a escala global. Moitas das especies de plantas invasoras máis agresivas do mundo son clonais.
García Vázquez, Natalia
core
Microevolution during the emergence of a monophasic Salmonella Typhimurium epidemic in the United Kingdom [PDF]
, 2016 Microevolutionary events associated with the emergence and clonal expansion of new 27 epidemic clones of bacterial pathogens hold the key to understanding the drivers of 28 epidemiological success.
A. Underwood +41 more
core +3 more sources
Emerging evidence for apical dominance in colonial branching Acropora corals
Frontiers in Marine ScienceColoniality and clonality in marine sessile organisms offer several advantages, such as better space occupation and directional growth. In coral colonies, species-specific functional connections are maintained among polyps, allowing for resource ...
Eleonora Re, Carlos M. Duarte
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The Toxoplasma gondii active serine hydrolase 4 regulates parasite division and intravacuolar parasite architecture [PDF]
, 2018 Hydrolase are enzymes that regulate diverse biological processes, including posttranslational protein modifications. Recent work identified four active serine hydrolases (ASHs) in Toxoplasma gondii as candidate depalmitoylases. However, only TgPPT1 (ASH1)
Amara, Neri +7 more
core +2 more sources
Parental effects of physiological integration on growth of a clonal herb
Frontiers in Plant ScienceAlthough numerous studies have independently tested the roles of physiological integration and parental effects on the performance of clonal plant species, few have assessed them simultaneously.
Li-Min Zhang, Li-Li Zheng, Fei-Hai Yu
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2020 In vivo tracking of retrovirus-tagged blood stem and progenitor cells is used to study hematopoiesis. Two techniques are used most frequently: sequencing the locus of retrovirus insertion, termed integration site analysis, or retrovirus DNA barcode ...
Jennifer E. Adair +9 more
doaj +1 more source