Results 51 to 60 of about 3,220,233 (234)

The Clonal Expansion Dynamics of the HIV-1 Reservoir: Mechanisms of Integration Site-Dependent Proliferation and HIV-1 Persistence

Viruses, 2021
More than 50% of the HIV-1 latent reservoir is maintained by clonal expansion. The clonally expanded HIV-1-infected cells can contribute to persistent nonsuppressible low-level viremia and viral rebound.
Yang-Hui Jimmy Yeh, Kerui Yang, Anya Razmi, Ya-Chi Ho   +3 more
doaj   +1 more source

Clonal integration in Phagmites australis mitigates effects of oil pollution on greenhouse gas emissions in a coastal wetland

, 2020
Clonal integration, i.e., resource sharing within clones, enables clonal plants to maintain biomass production when ramets (asexual individuals) under stress are connected to those not under stress.
Alpert, Peter, Han, Guang-Xuan, Gao, Jun-Qin, Yuan, Qing-Ye, Yu, Fei-Hai, An, Jing   +5 more
core   +1 more source

Clonal reconstruction from co-occurrence of vector integration sites accurately quantifies expanding clones in vivo [PDF]

, 2022
High transduction rates of viral vectors in gene therapies (GT) and experimental hematopoiesis ensure a high frequency of gene delivery, although multiple integration events can occur in the same cell.
Baldow, Christoph, Rudilosso, Laura, Glauche, Ingmar, Calabria, Andrea, Wagner, Sebastian, Gallina, Pierangela, Cesana, Daniela, Montini, Eugenio, Andrea Calabria, Laura Rudilosso, Christoph Baldow, Ingmar Glauche, Pierangela Gallina, Eugenio Montini, Sebastian Wagner, Daniela Cesana   +15 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Is Clonal Integration a Buffer for the Stress of Resource Acquisition Depletion in Eichhornia crassipes (Pontederiaceae) Ramets?

Stresses
Natural selection favors the allocation of finite resources to different functions maximizing fitness. In this sense, some functions may decrease whereas others increase when resources are limited in a process called a trade-off. However, a great variety
Guilherme Ramos Demetrio, Dalton Serafim, Flávia de Freitas Coelho   +2 more
doaj   +1 more source

Heterogeneous light supply affects growth and biomass allocation of the understory fern Diplopterygium glaucum at high patch contrast. [PDF]

PLoS ONE, 2011
Spatial heterogeneity in resource supply is common and responses to heterogeneous resource supply have been extensively documented in clonal angiosperms but not in pteridophytes.
Wei Guo, Yao-Bin Song, Fei-Hai Yu
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis

Molecular Therapy: Methods & Clinical Development, 2020
In vivo tracking of retrovirus-tagged blood stem and progenitor cells is used to study hematopoiesis. Two techniques are used most frequently: sequencing the locus of retrovirus insertion, termed integration site analysis, or retrovirus DNA barcode ...
Jennifer E. Adair, Mark R. Enstrom, Kevin G. Haworth, Lauren E. Schefter, Reza Shahbazi, Daniel R. Humphrys, Shaina Porter, Kenric Tam, Matthew H. Porteus, Hans-Peter Kiem   +9 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source