Results 61 to 70 of about 3,220,233 (234)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Integration as a two-way process in the EU? Assessing the Relationship between the European Integration Fund and the Common Basic Principles on Integration. CEPS Paperbacks, July 2011 [PDF]
, 2011 This report examines the nature, the limits and potential of the principle of integration as a two-way process of mutual accommodation between migrants and the receiving societies.
Atger, Anais Faure, Carrera, Sergio
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, 2018 A small number of previous studies investigating the potential advantages of clonal integration, have focused on the measurement of the costs and benefits of clonal integration at various N/P ratios. Clonal plants adaptively respond to abiotic stress but
Li, Bo +5 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Frontiers in Plant ScienceResistance traits of plants can be activated both at the damaged site and undamaged parts. Systemic resistance induced by local exogenous abscisic acid (ABA) application alleviated negative effect of low water availability on growth performance of clonal
Su-Juan Duan +12 more
doaj +1 more source
Photosynthetic response of Fragaria orientalis in different water contrast clonal integration
, 2009 The capacity to exchange resources and non-resource agents is one of the most outstanding features of clonal plants. Contrast between patches in a heterogeneous environment is the main external driving force behind integration effects.
Zhang, YC +4 more
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The Advantages of Clonal Integration Under Different Ecological Conditions: a Community-Wide Test [PDF]
, 2000 The connectedness of clonal plants has been shown to promote survival and growth in a variety of single-species, single-factor studies, but experiments comparing the relative advantages of clonality across multiple habitats and species are rare ...
Pennings, Steven C., Callaway, Ragan M.
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Survival and growth of epiphytic ferns depend on resource sharing
Frontiers in Plant Science, 2016 Locally available resources can be shared within clonal plant systems through physiological integration, thus enhancing their survival and growth.
Hua-Zheng eLu +15 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source