Results 81 to 90 of about 102,010 (264)

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses. [PDF]

, 2019
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure1-3. Curative strategies that target the reservoir are being tested4,5 and require accurate, scalable reservoir assays.
Antar, Annukka AR, Beg, Subul A, Bender, Alexandra M, Bertagnolli, Lynn N, Blankson, Joel N, Bruner, Katherine M, Bushman, Frederic D, Capoferri, Adam A, Deeks, Steven G, Fray, Emily J, Gregg, John, Ho, Ya-Chi, Jenike, Katharine M, Kufera, Joshua T, Kwon, Kyungyoon J, Laird, Gregory M, Margolick, Joseph B, Nobles, Christopher, Sengupta, Srona, Siliciano, Janet D, Siliciano, Robert F, Simonetti, Francesco R, Timmons, Andrew, Wada, Nikolas, Wang, Zheng, Zhang, Hao   +25 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Parental effects of physiological integration on growth of a clonal herb

Frontiers in Plant Science
Although numerous studies have independently tested the roles of physiological integration and parental effects on the performance of clonal plant species, few have assessed them simultaneously.
Li-Min Zhang, Li-Li Zheng, Fei-Hai Yu
doaj   +1 more source

Artificial Immune Systems - Models, algorithms and applications [PDF]

, 2010
Copyright © 2010 Academic Research Publishing Agency.This article has been made available through the Brunel Open Access Publishing Fund.Artificial Immune Systems (AIS) are computational paradigms that belong to the computational intelligence family and ...
Abbod, MF, Al-Enezi, JR, Alsharhan, S
core  

Network analysis identifies weak and strong links in a metapopulation system [PDF]

, 2008
The identification of key populations shaping the structure and connectivity of metapopulation systems is a major challenge in population ecology. The use of molecular markers in the theoretical framework of population genetics has allowed great advances
A. F. Rozenfeld, Brooks, C. M. Duarte, Dyer, E. A. Serrao, E. Hernandez-Garcia, Goldstein, Hey, Lago-Fern  ndez, Maslov, May, Newman, Pastor-Satorras, Proulx, Rozenfeld, S. Arnaud-Haond, V. M. Eguiluz, Wright, Wright   +18 more
core   +2 more sources

Preservation of seagrass clonal integration buffers against burial stress [PDF]

Journal of Experimental Marine Biology and Ecology, 2013
Q1
Tuya, Fernando, Espino, Fernando, Terrados, Jorge   +2 more
openaire   +3 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

'Towards a Conceptual Framework for Innate Immunity' [PDF]

, 2005
Innate immunity now occupies a central role in immunology. However, artificial immune system models have largely been inspired by adaptive not innate immunity.
Aickelin, Uwe, Twycross, Jamie
core   +3 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source