Results 221 to 230 of about 1,799,485 (379)

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

Journal of Virology, 1992
H. Schuitemaker, M. Koot, A. Neeltje, Kootstra, M. Dercksen, DE RUUDE.Y., Goede, R. P. Steenwijk, J. Lange, J. K. M. E. Schattenkerk, Frank, Miedema, M. Tersmette   +12 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Dissemination of New Methicillin-Resistant Staphylococcus aureus Clones in the Community

Journal of Clinical Microbiology, 2002
K. Okuma, K. Iwakawa, J. Turnidge, W. Grubb, J. Bell, F. O'Brien, G. Coombs, J. Pearman, F. Tenover, M. Kapi, C. Tiensasitorn, Teruyo Ito, K. Hiramatsu   +12 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

An improved CRISPR-Cas9 protein-based method for knocking out insect Sf9 cell genes. [PDF]

Appl Microbiol Biotechnol
Graça M, Virgolini N, Correia R, Escandell J, Roldão A.   +4 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Whole genome resequencing dataset of <i>Citrus maxima</i> cv. shating and its mutant clones. [PDF]

Data Brief
Ab Razak S, Abd Aziz NB, Zainal Abidin RA, Abd Majid AM, Kamarudin AS, Azmi NS, Ngah A, Razali MZ, Nordin MF.   +8 more
europepmc   +1 more source

Cloned Cytosine Deaminase Gene Expression ofBifidobacterium longumand Application to Enzyme/Pro-drug Therapy of Hypoxic Solid Tumors [PDF]

, 2002
Toshiyuki Nakamura, Takayuki Sasaki, Maiko Fujimori, Kazuyuki Yazawa, Yasunobu Kano, Jun Amano, Shun’ichiro Taniguchi   +6 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Genotype-to-phenotype mapping of somatic clonal mosaicism via single-cell co-capture of DNA mutations and mRNA transcripts. [PDF]

Cancer Discov
Yuan DJ, Zinno J, Botella T, Dhingra D, Wang S, Hawkins AG, Swett A, Sotelo J, Raviram R, Hughes C, Potenski C, Godfrey KD, Ainsworth KM, Xu S, Que J, Abrams JA, Yokoyama A, Kakiuchi N, Ogawa S, Landau DA.   +19 more
europepmc   +1 more source