Results 11 to 20 of about 82,588 (312)

Pharmacokinetic and Pharmacodynamic Modeling of Clonidine and Midazolam for Sedation in Pediatric Intensive Care. [PDF]

Paediatr Anaesth
ABSTRACT Background Clonidine and midazolam are routinely used in the pediatric intensive care unit for pain and sedation management, but target concentration and optimal dose are poorly defined for both drugs. The CloSed study is a multicenter, double‐blind, randomized, active‐controlled noninferiority trial with a 1:1 randomization between clonidine ...
Bardol M, Sheng Y, Baarslag M, Ceci A, Dörje F, Ilmoja ML, Larsson P, Lönnqvist PA, Methsvat T, Pokorna P, Rascher W, van Rosmalen J, Schroth M, Simonetti A, Tibboel D, Toni I, Tuleu C, Völkl TMK, Anderson BJ, Wimmer S, Standing JF, Neubert A, CloSed Consortium.   +22 more
europepmc   +2 more sources

Medication Safety in Intravenous Therapy: A Compatibility Study of Clonidine with Drugs Frequently Used in Intensive Care

Pharmaceutics, 2020
The intravenous pharmacotherapy of critically ill patients is extremely challenging due to the high number of drugs administered. We therefore evaluated the physicochemical compatibility of combinations of clonidine with drugs frequently used in an ...
Anna Katharina Koller, Sabine Krebs, Frank Dörje   +2 more
doaj   +1 more source

Efficacy of low dose intravenous dexmedetomidine versus clonidine in treatment of shivering during caesarean section under spinal anaesthesia: a double blind randomized controlled trial [PDF]

New Indian Journal of OBGYN, 2023
Objectives: Dexmedetomidine and clonidine have been used to prevent and treat shivering after spinal anaesthesia. A double blind randomized controlled trial was conducted to compare the efficacy and safety of low dose intravenous dexmedetomidine and ...
Karamchand Basumatary, Diganta Saikia, Ratindra Kumar Barman, Jagadish Basumatary, Joyanta Kumar Choudhury, Shashankar Das   +5 more
doaj   +1 more source

Effects of clonidine on the activity of the rat glutamate transporter EAAT3 expressed in oocytes [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundClonidine has been shown to be a potent neuroprotectant by acting at α2 receptors on glutamatergic neurons to inhibit the release of glutamate.
Jae Hee Woo, Jong In Han, Hee Jung Baik, Heeseung Lee   +3 more
doaj   +1 more source

Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors [PDF]

, 2010
The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse.
A Dzung Lê, AD Le, AH Tiong, AM Snoddy, AN Fricks-Gleason, Andy Weyer, AR Davis, AS Kreibich, B Lee, B Ribeiro Do Couto, B Wang, C Drouin, C Lanteri, C Orsini, CA Jiménez-Rivera, CA Rudoy, Chad E Beyer, CJ McDougle, D Highfield, D Weinshenker, David A Baker, DJ Macey, DJ Sanger, DM Platt, ED Abercrombie, F Leri, FH Gawin, G Bricca, GC Harris, GC Harris, HD Schmidt, Holly Caretta, J Stewart, JC Winter, JM Dwyer, JM Finlay, John R Mantsch, JR Schank, KM Kampman, KM Kampman, L Cervo, L Lu, LJ Vanderschuren, M Sofuoglu, M Sofuoglu, M Sofuoglu, ME Reith, MH Baumann, MJ Millan, MK Horne, MS Kleven, MW Feltenstein, MY Li, OA Tjurmina, Oliver Vranjkovic, PJ Fletcher, R Sinha, R Sinha, R Sinha, RD Spealman, RE Bernardi, RE Bernardi, RJ Smith, RM Eglen, S Deyama, S Erb, S Erb, S Erb, S Wee, SM Florin, T Belej, T Tanaka, T Watanabe, TC Rainbow, TJ Beveridge, TM Tzschentke, VA Redila, WL Woolverton, X Wang, XY Zhang, XY Zhang, Y Itzhak, Y Shaham, Y Shaham, Y Shaham, Y Shaham, ZJ Brown   +86 more
core   +3 more sources

Local Field Potential‐Based Programming: A Proof‐of‐Concept Pilot Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Programming deep brain stimulation (DBS) is still based on a trial‐and‐error approach, often becoming a time‐consuming process for both treating physicians and patients. Several strategies have been proposed to streamline DBS programming, most of which are preliminary and mainly address Parkinson's disease, a condition readily ...
Alfonso Fasano, Carolina Gorodetsky, Darcia Paul, Jürgen Germann, Aaron Loh, Han Yan, Peter L. Carlen, Sara Breitbart, Andres M. Lozano, George M. Ibrahim, Suneil K. Kalia   +10 more
wiley   +1 more source

Hypertensive Crisis in a Pediatric Patient Experiencing Clonidine Withdrawal

Case Reports in Pediatrics, 2022
Background. Clonidine, a central alpha-adrenoreceptor agonist, was initially developed as an antihypertensive. Though no longer commonly used for its original indication due to rebound hypertension after discontinuation, it is currently widely prescribed
Can Cao, Matthew L. Lorenz, Phillip Sojka, Allison W. Brindle, Lisa Swartz Topor   +4 more
doaj   +1 more source

Alcohol Withdrawal – Therapeutical Management in Surgical Patients with Upper Intestinal Bleeding [PDF]

, 2015
Psychological dependence involves a desire to use a drug to avoid the unpleasant withdrawal syndrome that results from cessation of exposure to it. Alcohol withdrawal syndrome is one of the most feared complications of alcohol addiction and sometimes can
Bogdan, Popescu, Cristian, Bălălău, Denisa, Cobani Oana, Gloria, Trambitasu, Negrei, Carolina, Valentin, Scăunașu Răzvan   +5 more
core   +4 more sources

Symptomatic treatment of children with anti-NMDAR encephalitis. [PDF]

, 2016
AIM: We performed the first study on the perceived benefit and adverse effects of symptomatic management in children with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis.
Brilot, F, Dale, R. C., Hong, M, Jones, H, Mohammad, Ss, Nosadini, M, Pillai, Sc, Sharpe, C   +7 more
core   +1 more source

Topical treatment of peripheral neuropathic pain: applying the evidence [PDF]

, 2017
Patients with peripheral neuropathic pain (NP) may only achieve partial pain relief with currently recommended first-line oral treatments, which are also associated with systemic adverse events.
Cruccu, Giorgio, Sommer, Claudia
core   +1 more source