Results 51 to 60 of about 59,295 (280)

Patient anxiety and modern elective surgery: a literature review [PDF]

, 2003
Medical advances have led to a considerable rise in the level of elective surgery undertaken as day-case surgery and with minimal hospital stay. However, amid such advances, preoperative psychological care has remained relatively static.
Mitchell, MJ
core   +1 more source

The implausibility of ‘usual care’ in an open system: sedation and weaning practices in Paediatric Intensive Care Units (PICUs) in the United Kingdom (UK) [PDF]

, 2015
Background: The power of the randomised controlled trial depends upon its capacity to operate in a closed system whereby the intervention is the only causal force acting upon the experimental group and absent in the control group, permitting a valid ...
B Ambuel, B Blackwood, B Blackwood, B Blackwood, B Blackwood, Bronagh Blackwood, C Maloney, CJL Newth, D Bieri, D Macrae, DL Jackson, E Ista, E Ista, F Frutos-Vivar, FK Foronda, FW Moler, J Rycroft-Malone, J Rycroft-Malone, J Rycroft-Malone, JA Durlak, K Harron, L Kohn, L Rose, LS Franck, Lyvonne Tume, M Cunliffe, NJ Vet, P O’Halloran, PA Jouvet, RP Dellinger, S Chawla, S Playfor, SI Merkel, SW Krechel, YN Poh   +34 more
core   +1 more source

Response to low-dose intrathecal clonidine in septuagenarians undergoing sub-umbilical surgeries: A study

Saudi Journal of Anaesthesia, 2015
Clonidine, an alpha-2-adrenergic agonist, may have a clinically relevant analgesic action but also a hypotensive action, when administered spinally. Aim: To evaluate the analgesic and circulatory effects of low-dose intrathecal clonidine co-administered ...
Jayashree Sen, Bitan Sen
doaj   +1 more source

Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review [PDF]

, 2019
Anorexia nervosa (AN) is a severe eating disorder affecting around 1 per 100 persons. However, the knowledge about its underlying pathophysiology is limited.
Schalla, Martha A., Stengel, Andreas
core   +1 more source

Trisomy 5p: Long Recognized, Rarely Published‐ Three New Cases and Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Complete trisomy 5p is a rare chromosomal disorder caused by a duplication of the short arm of chromosome 5. Current data suggest that complete trisomy 5p presents as a distinct clinical syndrome including but not limited to seizures, developmental delays, facial dysmorphisms, failure to thrive, and recurrent respiratory infections.
Gabriela J. Kim, Kristen N. Lee, Amanda B. Pritchard   +2 more
wiley   +1 more source

Clonidine Overdose as an Unusual Cause of Heart Failure

Journal of Investigative Medicine High Impact Case Reports, 2022
Clonidine is used as an antihypertensive medication due to its effect on decreasing peripheral vascular resistance and therefore lowering blood pressure.
Jagdeep Bhullar PharmD, Arti Patel MS4, Jaagruthi Chitithoti DO, Frederick Venter MD, Theingi Win MD, Fowrooz Joolhar MD   +5 more
doaj   +1 more source

Clonidine effects on pain evoked SII activity in humans [PDF]

, 2006
We investigated pain evoked activity in the human secondary sensory cortex (SII) following clonidine administration in six healthy volunteers using multi‐channel magnetoencephalography (MEG).
Bischoff, Petra, Bromm, Burkhart, Hauck, Michael, Lorenz, Juergen, Morrow, Thomas J., Schmidt, Gunther, Zimmermann, Roger   +6 more
core   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Sciatic lateral popliteal block with clonidine alone or clonidine plus 0.2% ropivacaine: effect on the intra-and postoperative analgesia for lower extremity surgery in children: a randomized prospective controlled study

BMC Anesthesiology, 2012
Background The effect of adding clonidine to local anesthetics for nerve or plexus blocks remains unclear. Most of the studies in adults have demonstrated the positive effects of clonidine on intra- and postoperative analgesia when used as an adjunctive ...
Petroheilou Kalliopi, Livanios Stavros, Zavras Nikolaos, Hager John, Fassoulaki Argyro   +4 more
doaj   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source