Results 51 to 60 of about 32,197 (228)

Challenges and Considerations in Manipulating Oral Dosage Forms in Paediatric Healthcare Settings: A Narrative Review

Acta Paediatrica, EarlyView.
A substantial proportion of oral drug administrations in children require manipulation due to the lack of age‐appropriate formulations. Common methods such as splitting, crushing, and dispersing tablets in fluids can compromise dose accuracy because of e.g., drug solubility.
M. Paulsson, R. Hamre Svendsen, J. K. N. Andersen, S. Kälvemark Sporrong, Y. Andersson, I. Tho   +5 more
wiley   +1 more source

Intraoperative clonidine vs lidocaine on hemodynamic response to laryngoscopic intubation and immune function in gynecological surgeries

Ain Shams Journal of Anesthesiology, 2020
Background This prospective randomised double-blind study was carried out on forty patients American Society of Anesthesiologists (ASA) physical status I–II , aged 40–60 years, scheduled for elective abdominal gynecological surgeries under general ...
Sawsan Gaber Mohamed, Noha Mahmoud Hamdy, Amira Abo Elnasr Awad   +2 more
doaj   +1 more source

The Use of miRNA Panel as a Growth Plate Marker of Short‐Term Response to GH

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Recombinant human growth hormone (GH) therapy shows variable growth responses in patients with growth hormone deficiency (GHD), highlighting the need for reliable biomarkers to predict individual sensitivity. Objective This study investigated circulating microRNAs (miRNAs) involved in growth plate regulation during GH therapy in ...
Caroline Rosa Pellicciari, Thayna Rosa Bispo, Itatiana Ferreira Rodart, Leandra Steinmetz, Adriana Aparecida Siviero Miachon, Angela Maria Spinola e Castro, Durval Damiani, Cristiane Kochi, Carlos Alberto Longui   +8 more
wiley   +1 more source

The effect of pretreatment with clonidine on propofol consumption in opium abuser and non-abuser patients undergoing elective leg surgery

Journal of Research in Medical Sciences, 2012
Objective: Clonidine, an alpha-2 adrenergic agonist, increases the quality of perioperative sedation and analgesia with a few side effects. This study was designed to assess the effect of clonidine premedication on the anesthesics used for elective below
Morteza Jabbari Moghadam, Davood Ommi, Alireza Mirkheshti, Mehdi Shadnoush, Ali Dabbagh   +4 more
doaj  

Neuronal oscillatory imbalances in GNAO1‐related disorders associated with disease severity

Epilepsia, EarlyView.
Abstract Objective This study investigates excitatory/inhibitory (E/I) imbalances in GNAO1‐related disorders (GNAO1‐RD), linking neuronal dysfunction to clinical severity using E/I‐sensitive electroencephalography (EEG) analyses. Methods We conducted an observational study involving 12 children with GNAO1‐RD caused by pathogenic variants and 36 age ...
Tongyu Wang, Jana Domínguez‐Carral, William Grant Ludlam, Mar Junyent Segarra, Montserrat Fornaguera Marti, Hilgo Bruining, Kirill A. Martemyanov, Klaus Linkenkaer‐Hansen, Juan Dario Ortigoza‐Escobar   +8 more
wiley   +1 more source

Clonidine as an adjuvant to hyperbaric bupivacaine for spinal anesthesia in elderly patients undergoing lower limb orthopedic surgeries

Saudi Journal of Anaesthesia, 2014
Background: In elderly patients, use of adjuvant with small doses of local anesthetics is a preferred technique for spinal anesthesia for lower limb surgeries. This study tested the hypothesis that addition of small doses of clonidine augments the spinal
Deepti Agarwal, Manish Chopra, Medha Mohta, Ashok Kumar Sethi   +3 more
doaj   +1 more source

Hyperhidrosis: don't sweat it

Internal Medicine Journal, EarlyView.
Abstract Hyperhidrosis is an under‐reported and under‐treated condition that causes significant patient morbidity. Secondary causes require consideration, but the vast majority of cases are idiopathic. The condition is encountered by a range of clinicians, including neurologists, dermatologists and endocrinologists, and it pays to be familiar with the ...
Mitchell J. Lycett, Karl Ng
wiley   +1 more source

Efficacy of Analgesic Effects of Low Dose Intrathecal Clonidine as Adjuvant to Bupivacaine

Indian Journal of Anaesthesia, 2007
Clonidine (α-2-adrenergic agonist) has analgesic effect at spinal level mediated by postsynaptically situated α-2-adrenoreceptors in dorsal horn of spinal cord. Previous studies have used this drug intrathecally in higher dosages.
B S Sethi, Mary Samuel, Deepak Sreevastava   +2 more
doaj  

Growth hormone stimulation test with Clonidine and Arginine an unreported side effect

Journal of Clinical and Translational Endocrinology Case Reports, 2020
Clonidine is one of the commonly used pharmacological agents for growth hormone stimulation. It is considered generally safe, with only few non-serious reported side effects.
Renad AbdelNabi, Reem Al Khalifah
doaj  

A case report of clonidine induced syncope: a review of central actions of an old cardiovascular drug

BMC Pharmacology and Toxicology, 2018
Background Clonidine is an imidazoline sympatholytic, acting on both α2-adrenergic and imidazoline receptors in the brainstem to induce antihypertensive and negative chronotropic effects in the vasculature and heart respectively.
Alexander J. Sandweiss, Christopher M. Morrison, Anne Spichler, John Rozich   +3 more
doaj   +1 more source