Results 71 to 80 of about 32,197 (228)

Treatment Experience Using a Micro‐Induction Buprenorphine Protocol for Chronic Pain in Pediatric Sickle Cell Disease

open access: yesPediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT Background Patients with sickle cell disease (SCD) experience painful vaso‐occlusive episodes that increase with age; a subset develops chronic pain (CP). CP is usually managed with acute pain management guidelines despite evidence of ineffectiveness.
Ashwin Patel   +6 more
wiley   +1 more source

Passionflower in the treatment of opiates withdrawal: a double blind and randomized controled trial

open access: yesJournal of Medicinal Plants, 2002
Clonidine-base detoxification has been utilized as the main protocol for several years However, detoxification with clondine has its limitation, including lack of efficacy for mental symptoms.
  +4 more
doaj  

Advancing antihypertensive drug development

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 15, Page 3389-3410, August 2025.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu   +5 more
wiley   +1 more source

Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders

open access: yesDevelopmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1095-1102, August 2025.
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 This original article is commented by Thompson on pages 975–976 of this issue. Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐
Russell C. Dale   +14 more
wiley   +1 more source

Does oral clonidine have an effect on pain control after laparoscopic cholecystectomy? A double-blind randomized clinical trial study

open access: yesفصلنامه دانشگاه علوم پزشکی جهرم, 2021
Introduction: Postoperative pain is an unpleasant experience. This process causes physiological disorders in all systems of the body. Clonidine as an alpha dual agonist is one of the drugs used to control pain after laparoscopic cholecystectomy ...
Mehrdad Malekshoar   +2 more
doaj  

A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning

open access: yesTrials, 2009
Background An estimated 2–3 million people are acutely poisoned by organophosphorus pesticides each year, mostly in the developing world. There is a pressing need for new affordable antidotes and clonidine has been shown to be effective in animal studies.
Karunatilake Harindra   +6 more
doaj   +1 more source

Roberts's syndrome and clonidine. [PDF]

open access: bronze, 1979
C Stoll, Jacov Levy, D Beshara
openalex   +1 more source

Single Deficit, Comorbidity or Varying Degrees of Dysfunction? New Directions to the Study of Learning Disorders

open access: yesApplied Cognitive Psychology, Volume 39, Issue 4, July/August 2025.
ABSTRACT Research on neurodevelopmental disorders (NDDs) has led us to refine our theoretical and methodological approaches. We explore whether new deficit clusters in line with the Research Domain Criteria, a novel multifactorial framework, optimally explain known conditions such as ADHD, DLD, or SLD in reading.
Evgenia‐Peristera Kouki   +3 more
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi   +6 more
wiley   +1 more source

Subarachnoid clonidine and trauma response in cardiac surgery with cardiopulmonary bypass

open access: yesRevista Brasileira de Anestesiologia, 2014
Background and objectives: The intense trauma response triggered by cardiopulmonary bypass can lead to increased morbidity and mortality. The present study evaluated whether clonidine, a drug of the class of α-2 agonists, administered by spinal route ...
Claudia Gissi da Rocha Ferreira   +1 more
doaj   +1 more source

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