Results 71 to 80 of about 32,197 (228)
ABSTRACT Background Patients with sickle cell disease (SCD) experience painful vaso‐occlusive episodes that increase with age; a subset develops chronic pain (CP). CP is usually managed with acute pain management guidelines despite evidence of ineffectiveness.
Ashwin Patel+6 more
wiley +1 more source
Passionflower in the treatment of opiates withdrawal: a double blind and randomized controled trial
Clonidine-base detoxification has been utilized as the main protocol for several years However, detoxification with clondine has its limitation, including lack of efficacy for mental symptoms.
+4 more
doaj
Advancing antihypertensive drug development
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu+5 more
wiley +1 more source
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 This original article is commented by Thompson on pages 975–976 of this issue. Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐
Russell C. Dale+14 more
wiley +1 more source
Introduction: Postoperative pain is an unpleasant experience. This process causes physiological disorders in all systems of the body. Clonidine as an alpha dual agonist is one of the drugs used to control pain after laparoscopic cholecystectomy ...
Mehrdad Malekshoar+2 more
doaj
Background An estimated 2–3 million people are acutely poisoned by organophosphorus pesticides each year, mostly in the developing world. There is a pressing need for new affordable antidotes and clonidine has been shown to be effective in animal studies.
Karunatilake Harindra+6 more
doaj +1 more source
Roberts's syndrome and clonidine. [PDF]
C Stoll, Jacov Levy, D Beshara
openalex +1 more source
ABSTRACT Research on neurodevelopmental disorders (NDDs) has led us to refine our theoretical and methodological approaches. We explore whether new deficit clusters in line with the Research Domain Criteria, a novel multifactorial framework, optimally explain known conditions such as ADHD, DLD, or SLD in reading.
Evgenia‐Peristera Kouki+3 more
wiley +1 more source
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi+6 more
wiley +1 more source
Subarachnoid clonidine and trauma response in cardiac surgery with cardiopulmonary bypass
Background and objectives: The intense trauma response triggered by cardiopulmonary bypass can lead to increased morbidity and mortality. The present study evaluated whether clonidine, a drug of the class of α-2 agonists, administered by spinal route ...
Claudia Gissi da Rocha Ferreira+1 more
doaj +1 more source