Results 31 to 40 of about 687,759 (305)
Polylinguality and Transcultural Practices, 2019 The British-Japanese writer Kazuo Ishiguro was awarded the Nobel Prize for the anti-utopian novel “Do not let me go” in 2017. The authors of the article in the framework of ontological poetics consider the aesthetic advantages of the work, paying close ...
Zukhra A. Kuchukova, Liana B. Berberova
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The First Genomic Analysis of Visna/Maedi Virus Isolates in China
Frontiers in Veterinary Science, 2022 Visna/Maedi virus (VMV) is a neglected pathogen that damages sheep and goats' nervous and respiratory systems. The virus was discovered 80 years ago and has been endemic in China for nearly four decades; nevertheless, there is little information ...
Jian-Yong Wu +6 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Environmental determinants of male infertility: emerging threats and technological interventions
Frontiers in MedicineMale infertility stands as a significant global concern, contributing to nearly 50% of infertility cases and affecting approximately 7% of the male population. Mounting evidence identifies environmental degradation is a major, modifiable driver. Numerous
P. Jagadesh, T. B. Sridharan
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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Toxicology ReportsExposure to air pollution poses significant risks to human health, including detrimental effects on the reproductive system, affecting both men and women.
Abilash D, Sridharan T B
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Ars Mathematica Contemporanea, 2014 Each finite graph on n vertices determines a special ( n − 1) -fold covering graph that we call the clone cover . Several equivalent definitions and basic properties about this remarkable construction are presented. In particular, we show that for k ≥ 2 , the clone cover of a k -connected graph is k -connected, the clone cover of a ...
Aleksander Malnic +2 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Spatial dynamics of mTOR pathway activity during bovine embryo development
Frontiers in Cell and Developmental BiologyThe mTOR pathway regulates cell proliferation, growth, survival, and metabolism by integrating nutritional and growth factor signaling. In embryos, its activity is influenced by the availability of nutrients in the culture medium, and it can affect the ...
Francieli P. Berling +4 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source