Results 41 to 50 of about 695,609 (307)

Integrative analysis of swine infectious diseases in the context of xenotransplantation

International Journal of Infectious Diseases
Background: The initiation of clinical pig xenotransplantation trials offers the prospect of alleviating global organ shortage. However, current knowledge of swine-derived microorganisms relevant to xenotransplantation remains fragmented due to the ...
Jiayu Li, Kai Liu, Muhammad Ameen Jamal, Kaixiang Xu, Wenmin Cheng, Baoyu Jia, Hong-Ye Zhao, Hongzhou Lu, Jay A. Fishman, Hong-Jiang Wei   +9 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Alcohol and male infertility: is there a safe dose? Evidence of accessory gland dysfunction, oxidative stress, and sperm DNA damage

Frontiers in Reproductive Health
IntroductionAlcohol consumption is a recognized modifiable lifestyle factor affecting male reproductive health. Yet, its dose-dependent effects on accessory gland function and sperm genomic integrity remains poorly elucidated.
P. Jagadesh, T. B. Sridharan
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

To clone or not to clone.

Journal of Postgraduate Medicine, 2003
'There is perhaps no phenomenon in the field of biology that touches so many fundamental questions as the union of the germ cells in the act of fertilisation; in the supreme event all the strands of webs of two lives are gathered in one knot, from which they diverge again and are rewoven in a new individual life history.
openaire   +2 more sources

Cloning and gene expression of alkane hydroxylase gene from Pseudomonas putida [PDF]

مجله بیوتکنولوژی کشاورزی, 2017
Pseudomonas putida is a bacterium that has ability to growth on limited substrates that mainly is alkanes. The ability to use wide range of hydrocarbons is advantage of this bacterium to other bacteria community. P. putida have alkane hydroxylase system (
Mahdi Hasanshahian, Hadi Ravan
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Molecular Cloning and Functional Characterization of a Salt Tolerance-Associated Gene IbNFU1 from Sweetpotato

Journal of Integrative Agriculture, 2013
Iron-sulfur cluster biosynthesis involving the nitrogen fixation (Nif) proteins has been proposed as a general mechanism acting in various organisms. NifU-like protein may play an important role in protecting plants against abiotic and biotic stresses ...
Lian-jun WANG, Shao-zhen HE, Hong ZHAI, De-gao LIU, Yan-nan WANG, Qing-chang LIU   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Easy method for six-fragment Golden Gate Assembly of modular vectors

BioTechniques, 2023
Efficient cloning techniques are a requirement for synthetic biology. This study provides a simplified cloning method based on Golden Gate Assembly that can be used for rapid vector construction.
Ionut Adrian Cepleanu-Pascu, Miruna Stan, Sebastian Cocioba, Ileana Stoica   +3 more
doaj   +1 more source