Results 31 to 40 of about 148,561 (252)

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Upper gastrointestinal lesions in patients receiving clopidogrel anti-platelet therapy

Journal of the Formosan Medical Association, 2012
Clopidogrel is associated with a high incidence of upper gastrointestinal bleeding in high-risk patients. However, the characteristic upper gastrointestinal lesions in symptomatic clopidogrel users remain unclear.
Tzung-Jiun Tsai, Kwok-Hung Lai, Ping-I. Hsu, Chiun-Ku Lin, Hoi-Hung Chan, Hsien-Chung Yu, Huay-Min Wang, Kung-Hung Lin, Kai-Ming Wang, Shiuh-Nan Chang, Chun-Peng Liu, Shin-Hung Hsiao, Hung-Ru Huang, Ching-Huang Lin, Feng-Woei Tsay   +14 more
doaj   +1 more source

Cost-effectiveness of Platelet Function-Guided Strategy with Clopidogrel or Ticagrelor [PDF]

, 2019
Some patients treated with dual antiplatelet therapy (DAPT) following acute coronary syndrome (ACS) can still exhibit heightened residual platelet reactivity (HRPR), which is potentially linked to adverse vascular outcomes.
Liudmila Buryachkovskaya, Nikita Lomakin, Victor Serebruany, Anna Rudakova   +3 more
core   +1 more source

Enhancing Blood Circulation With Epsilon‐Near‐Zero (ENZ) Materials via the Far‐Infrared Window of Human Skin

Advanced Science, EarlyView.
Epsilon‐near‐zero (ENZ) silicon carbide enables a selective far‐infrared emitter spectrally aligned with the human skin window around 10 µm for wavelength‐matched thermal therapy. In 25 within‐subject trials (50 hands) monitored by laser speckle contrast imaging, SiC increases blood perfusion by 30.2% versus a broadband graphite emitter while ...
Wen‐Teng Yao, Shan‐Chiao Yang, Ming‐Feng Tsai, Hsuen‐Li Chen   +3 more
wiley   +1 more source

Impact of clopidogrel in coronary artery bypass grafting [PDF]

, 2004
Objective: Clopidogrel has become the standard of care to prevent thrombotic complications following cardiological interventions, in particular intracoronary stenting.
Englberger, Lars, Carrel, Thierry, Faeh, Bettina, Eberli, Franz, Meier, Bernhard, Berdat, Pascal A.   +5 more
core   +1 more source

Clinically Relevant Bleeding in Individuals With Cancer: Insights From a Nationwide Cohort Study

American Journal of Hematology, EarlyView.
ABSTRACT Cancer care is often complicated by coagulopathy leading to thrombosis and bleeding. While venous thromboembolism (VTE) has been extensively studied, bleeding remains an underestimated threat. To address this knowledge gap, we leveraged the Epic Cosmos database to determine the impact of cancer‐associated clinically relevant bleeding (CRB) in ...
Ming Y. Lim, Radhika Gangaraju, Omid Jafari, Zihan Yang, Joyce W. T. Tiong, Elizabeth C. L. Chiang, Shengling Ma, Jun Y. Jiang, Justine Ryu, Barbara D. Lam, Mrinal Ranjan, Ang Li   +11 more
wiley   +1 more source

Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood

Advanced NanoBiomed Research, EarlyView.
Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Anke Schmidt, Linus Hübner, Julia van der Linde   +5 more
wiley   +1 more source

Clopidogrel, a P2Y12 receptor antagonist, potentiates the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis.

PLoS ONE, 2011
The P2Y12 receptor plays a crucial role in the regulation of platelet activation by several agonists, which is irreversibly antagonized by the active metabolite of clopidogrel, a widely used anti-thrombotic drug.
Analia E Garcia, Sripal R Mada, Mario C Rico, Raul A Dela Cadena, Satya P Kunapuli   +4 more
doaj   +1 more source

P2Y12 Inhibitors in Acute Coronary Syndromes: A Real-World, Community-Based Comparison of Ischemic and Bleeding Outcomes

Journal of Interventional Cardiology, 2023
Background. Randomized trials have shown superiority of the novel P2Y12 inhibitors over clopidogrel in patients with acute coronary syndrome (ACS), but clinical benefit in the community remains controversial.
Amit Sachdeva, Ratnabhushan Mutyala, Neha Mantri, Shiyun Zhu, Edward McNulty, Matthew Solomon   +5 more
doaj   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source