Results 31 to 40 of about 148,576 (255)
A Comparison of Aspirin and Clopidogrel with or without Proton Pump Inhibitors for the Secondary Prevention of Cardiovascular Events in Patients at High Risk for Gastrointestinal Bleeding [PDF]
, 2011 Objective: This study was conducted to compare the risk of recurrent hospitalization for major gastrointestinal (GI) complications (peptic ulcer, bleeding, and perforation) in patients at high GI risk who require ongoing antiplatelet therapy (aspirin ...
蕭斐元;蔡憶文;黃文鴻;溫有汶;陳珮芬;郭耿南 +1 more
core +1 more source
European Journal of Medical Research, 2010 Background Dual therapy with aspirin and clopidogrel increases the risk of gastrointestinal bleeding. Therefore, co-therapy with a proton pump inhibitor (PPI) is recommended by most guidelines.
Kenngott S +6 more
doaj +1 more source
A study on the impact of CYP2C19 genotype and platelet reactivity assay on patients undergoing PCI
Indian Heart Journal, 2015 Background: A thorough understanding of the patient's genotype and their functional response to a medication is necessary for improving event free survival.
P.C. Rath +9 more
doaj +1 more source
Scientific Reports, 2021 Clopidogrel is converted to its active metabolite by cytochrome P450 isoenzymes and irreversibly inhibits platelet activation by antagonizing the adenosine-diphosphate (ADP) receptor.
Yu Ueda +8 more
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2015 Aim. To study prevalence of resistance to acetylsalicylic acid, clopidogrel and dual resistance in percutaneous coronary intervention (PCI), to identify clinical risk factors of resistance development, to study effects of concomitant therapy on ...
V. A. Sulimov, E. V. Moroz
doaj +3 more sources
Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset [PDF]
, 2010 <p><b>Background and Purpose:</b> Antiplatelets (APs) may increase the risk of symptomatic intracerebral hemorrhage (ICH) following intravenous thrombolysis after ischemic stroke.</p> <p><b>Methods:</b> We ...
Wahlgren, N. +32 more
core +1 more source
Stroke genetics: prospects for personalized medicine. [PDF]
, 2012 Epidemiologic evidence supports a genetic predisposition to stroke. Recent advances, primarily using the genome-wide association study approach, are transforming what we know about the genetics of multifactorial stroke, and are identifying novel stroke ...
Markus Hugh S, Hugh S Markus, Markus, HS
core +1 more source
Outcome of stroke patients on clopidogrel plus proton-pump inhibitors: a single-center cohort study
Annals of Saudi Medicine, 2019 BACKGROUND: Recent studies suggest a higher risk of adverse cardiovascular outcome and mortality in patients co-prescribed clopidogrel with proton pump inhibitors (PPI). OBJECTIVE: Investigate the impact of concomitant prescription of clopidogrel and PPI
Rahaf A. Alghamdi +4 more
doaj +1 more source
Hepatocellular toxicity of clopidogrel: Mechanisms and risk factors [PDF]
, 2013 Clopidogrel is a prodrug used widely as a platelet aggregation inhibitor. After intestinal absorption, approximately 90% is converted to inactive clopidogrel carboxylate and 10% via a two-step procedure to the active metabolite containing a mercapto ...
Lindinger, Peter W +7 more
core +1 more source
International Journal of Gerontology, 2018 Summary: Background: This study aims to measure platelet aggregation with thromboelastography (TEG) and observe low response to clopidogrel in patients with acute coronary syndrome (ACS) receiving dual antiplatelet therapy.
Lijia Zhao +3 more
doaj +1 more source