Results 51 to 60 of about 141,477 (341)
Changes in Practice Patterns of Clopidogrel in Combination with Proton Pump Inhibitors after an FDA Safety Communication. [PDF]
PLoS ONE, 2016 OBJECTIVES:In 2009, the FDA issued a warning that omeprazole--a proton pump inhibitor (PPI)--reduces the antithrombotic effect of clopidogrel by almost half when taken concomitantly.
Annie Guérin +6 more
doaj +1 more source
Efficacy and Safety of Clopidogrel With and Without a Proton Pump Inhibitor: A Systematic Review and Meta-Analysis. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Classifications of drug interaction alerts regarding clopidogrel and a proton pump inhibitor (PPI) differ between knowledge resources. In this systematic review, Medline, Embase, and the Cochrane Library were searched for randomized controlled trials (RCTs) applying PICO criteria: P = patients on clopidogrel; I = intervention: PPI (subgroup ...
Axelsson MAB +3 more
europepmc +2 more sources
Aspirin and Clopidogrel Resistance [PDF]
Mayo Clinic Proceedings, 2006 Despite aspirin's and clopidogrel's proven benefit in reducing cardiovascular (CV) events, recurrent CV events still occur in patients receiving antiplatelet therapy. Many of these patients are resistant or only partially responsive to the antiplatelet effects of aspirin and clopidogrel, as determined by standard platelet assays.
Richard A. Lange +4 more
openaire +3 more sources
The synthesis of clopidogrel [PDF]
IOP Conference Series: Materials Science and Engineering, 2017 Cardiac and cerebrovascular disease is a common disease. It is well recognized that antiplatelet agent is effective in the prevention and treatment of thrombosis. Clopidogrel is one of thieno pyridine derivatives, which can inhibit ADP-induced platelet aggregation.
Yuanjun Huang, Qingxin Zhu
openaire +1 more source
Outcome of stroke patients on clopidogrel plus proton-pump inhibitors: a single-center cohort study
Annals of Saudi Medicine, 2019 BACKGROUND: Recent studies suggest a higher risk of adverse cardiovascular outcome and mortality in patients co-prescribed clopidogrel with proton pump inhibitors (PPI). OBJECTIVE: Investigate the impact of concomitant prescription of clopidogrel and PPI
Rahaf A. Alghamdi +4 more
doaj +1 more source
Clopidogrel for the Hot Patient [PDF]
Circulation: Cardiovascular Interventions, 2009 Inflammation plays a critical role in the initiation, progression, and clinical complications of atherosclerosis.1 Experimental evidence indicates that lesion formation is dependent on heterotypic interactions among immune cells, endothelial cells, and platelets.
Daniel I. Simon, Matthew L. Bilodeau
openaire +3 more sources
Coming safely to a stop : a review of platelet activity after cessation of antiplatelet drugs [PDF]
, 2015 Funding Isobel Ford is an employee of the University of Aberdeen. The research for the writing of this review received no specific grant from any funding agency in the public, commercial, or not-forprofit sectorsPeer ...
Ford, Isobel
core +1 more source
Clopidogrel with aspirin in acute minor stroke or transient ischemic attack.
New England Journal of Medicine, 2013 BACKGROUND Stroke is common during the first few weeks after a transient ischemic attack (TIA) or minor ischemic stroke. Combination therapy with clopidogrel and aspirin may provide greater protection against subsequent stroke than aspirin alone ...
Klopidogrel S Aspirinem +10 more
semanticscholar +1 more source
Brazilian Journal of Cardiovascular SurgeryIntroduction: Antiplatelet therapy after coronary artery bypass graft (CABG) has been used. Little is known about the predictors and efficacy of clopidogrel in this scenario. Objective: Identify predictors of clopidogrel following CABG.
Paulo Roberto L. Prates +9 more
doaj +1 more source
Swiss Medical Weekly, 2012 BACKGROUND: Patients who have acute coronary syndromes with or without ST-segment elevation have high rates of major vascular events. We evaluated the efficacy of early clopidogrel administration (300 mg) (
Jean Christophe Stauffer +5 more
doaj +1 more source