Results 51 to 60 of about 125,001 (364)

RESISTANCE TO ANTIPLATELET DRUGS (ASPIRIN, CLOPIDOGREL) IN PATIENTS UNDERGOING ELECTIVE PERCUTANEOUS CORONARY INTERVENTION

Рациональная фармакотерапия в кардиологии, 2015
Aim. To study prevalence of resistance to acetylsalicylic acid, clopidogrel and dual resistance in percutaneous coronary intervention (PCI), to identify clinical risk factors of resistance development, to study effects of concomitant therapy on ...
V. A. Sulimov, E. V. Moroz
doaj   +3 more sources

Clopidogrel, a P2Y12 receptor antagonist, potentiates the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis. [PDF]

PLoS ONE, 2011
The P2Y12 receptor plays a crucial role in the regulation of platelet activation by several agonists, which is irreversibly antagonized by the active metabolite of clopidogrel, a widely used anti-thrombotic drug.
Analia E Garcia, Sripal R Mada, Mario C Rico, Raul A Dela Cadena, Satya P Kunapuli   +4 more
doaj   +1 more source

Cessation of dual antiplatelet therapy and cardiovascular events following acute coronary syndrome [PDF]

, 2019
Objective: To assess whether cardiovascular events are increased after cessation of dual antiplatelet therapy (DAPT) following acute coronary syndrome (ACS) and to explore predictors for recurrent events after DAPT cessation during long-term follow-up.
Berry, Colin, Dawson, Jesse, Mazlan-Kepli, Wardati, Walters, Matthew   +3 more
core   +1 more source

The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma

European Journal of Clinical Investigation, Volume 53, Issue 1, January 2023., 2023
Abstract Aim To evaluate the impact of antiplatelet therapy (APT)on the incidence of hepatocellular carcinoma (HCC) and mortality following its treatment. Methods A systematic literature search was performed using PubMed and Cochrane Central Register of Controlled Trials Databases.
Quirino Lai, Nicoletta De Matthaeis, Michele Finotti, Giovanni Galati, Giuseppe Marrone, Fabio Melandro, Filomena Morisco, Daniele Nicolini, Riccardo Pravisani, Edoardo G. Giannini, the Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group, Aglitti A, Aliberti C, Baccarani U, Bhoori S, Borzio M, Brancaccio G, Burra P, Cabibbo G, Casadei Gardini A, Carrai P, Cillo U, Conti F, Cucchetti A, D’Ambrosio R, Dell’Unto C, Di Costanzo GG, Di Sandro S, Foschi FG, Fucilli F, Gambato M, Gasbarrini A, Giuliante F, Ghinolfi D, Grieco A, Gruttaduria S, Guarino M, Kostandini A, Iavarone M, Lenci I, Levi Sandri GB, Losito F, Lupo LG, Manzia TM, Mazzocato S, Mescoli C, Miele L, Muley M, Persico M, Plaz Torres MC, Pompili M, Ponziani FR, Rapaccini GL, Rendina M, Renzulli M, Rossi M, Rreka E, Russo FP, Sacco R, Sangiovanni A, Sessa A, Simonetti N, Sposito C, Tortora R, Trevisani F, Viganò L, Viganò M, Villa E, Vincenzi V, Violi P, Vitale A   +70 more
wiley   +1 more source

A study on the impact of CYP2C19 genotype and platelet reactivity assay on patients undergoing PCI

Indian Heart Journal, 2015
Background: A thorough understanding of the patient's genotype and their functional response to a medication is necessary for improving event free survival.
P.C. Rath, Sundar Chidambaram, Pallavi Rath, Byomakesh Dikshit, Sudhir Naik, Prashant K. Sahoo, Brajraj Das, Mohanshankar Mahalingam, Lakshmipathi Khandrika, Jugnu Jain   +9 more
doaj   +1 more source

A genetic polymorphism in P2RY 1 impacts response to clopidogrel in cats with hypertrophic cardiomyopathy

Scientific Reports, 2021
Clopidogrel is converted to its active metabolite by cytochrome P450 isoenzymes and irreversibly inhibits platelet activation by antagonizing the adenosine-diphosphate (ADP) receptor.
Yu Ueda, Ronald H. L. Li, Nghi Nguyen, Eric S. Ontiveros, Samantha L. Kovacs, Maureen S. Oldach, Karen M. Vernau, Michael H. Court, Joshua A. Stern   +8 more
doaj   +1 more source

More, More, More: Reducing Thrombosis in Acute Coronary Syndromes Beyond Dual Antiplatelet Therapy-Current Data and Future Directions. [PDF]

, 2018
© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.Common to the pathogenesis of acute coronary syndromes (ACS) is the formation of arterial thrombus, which results from platelet activation and triggering of the ...
Farag M, Hirsh J, Ibanez B, Mega JL, Park KW, Suh JW, Valgimigli M   +6 more
core   +2 more sources

Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events.

New England Journal of Medicine, 2006
BACKGROUND Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been studied in a broad population of patients at high risk for atherothrombotic events.
Deepak L. Bhatt, K. Fox, W. Hacke, P. Berger, H. Black, W. Boden, P. Cacoub, E. Cohen, M. Creager, J. Easton, M. Flather, S. Haffner, C. Hamm, G. Hankey, S. Johnston, K. Mak, J. Mas, G. Montalescot, T. Pearson, P. Steg, S. Steinhubl, M. Weber, D. Brennan, Liz Fabry-Ribaudo, J. Booth, E. Topol   +25 more
semanticscholar   +1 more source

Stroke genetics: prospects for personalized medicine. [PDF]

, 2012
Epidemiologic evidence supports a genetic predisposition to stroke. Recent advances, primarily using the genome-wide association study approach, are transforming what we know about the genetics of multifactorial stroke, and are identifying novel stroke ...
A Gschwendtner, A Hassan, A Helgadottir, A Helgadottir, A Joutel, A Viswanathan, AB Singleton, AJ Bowes, AV Shirodkar, B Rohrer, C Bellenguez, CAPRIE Steering Committee, CS Ku, D Sibbing, DF Gudbjartsson, DJ Klionsky, DK Wysowski, DL Bhatt, DR Holmes Jr, DS Budnitz, E Flossmann, G Paré, HC Diener, HS Markus, HS Markus, Hugh S Markus, J Hardy, JA Johnson, JB Olesen, JF Meschia, JL Mega, JN Hirschhorn, JT O'Brien, L Wang, M Dichgans, M Kubo, M Serizawa, MA Ikram, MV Holmes, P Jerrard-Dunne, P Kraft, P Polychronopoulos, PC Ng, RL Sacco, RS Epstein, S Bevan, S Gretarsdottir, S Gretarsdottir, S Lanfranconi, S Olsson, S Seshadri, S Seshadri, SE Nissen, The International Warfarin Pharmacogenetics Consortium, VG Manolopoulos, VL Roger   +55 more
core   +2 more sources

Detection and prediction of clopidogrel treatment failures using longitudinal structured electronic health records [PDF]

arXiv, 2023
We propose machine learning algorithms to automatically detect and predict clopidogrel treatment failure using longitudinal structured electronic health records (EHR). By drawing analogies between natural language and structured EHR, we introduce various machine learning algorithms used in natural language processing (NLP) applications to build models ...
arxiv