Results 101 to 110 of about 2,948,630 (210)

Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
Platelets, particularly tumor‐educated platelets (TEPs), play a crucial role in cancer diagnosis and treatment. TEPs undergo molecular changes in RNA and protein profiles, making them valuable biomarkers for diagnosis, prognosis, and monitoring. In nanomedicine, platelets serve as drug carriers in tumor‐targeted nanomaterials, enhancing specificity and
Xin Wang, Jie Chen, Hubing Shi
wiley   +1 more source

9-(4'-dimethylaminophenyl)-2,6,7-trihydroxy-xanthene-3-one is a potentially novel antiplatelet drug which antagonizes the effect of thromboxane A2 [PDF]

, 2018
Background: Currently, used oral antiplatelet drugs are both limited and associated with the risk of treatment failure/resistance. Research in this area is hence highly desired.
Applová, Lenka, Durić, Kemal, Karlíčková, Jana, Macáková, Kateřina, Mladĕnka, Přemysl, Muratović, Samija, Saso, Luciano, Veljović, Elma, Završnik, Davorka   +8 more
core   +1 more source

30‐Day DAPT in Patients at High Bleeding Risk Undergoing PCI With Biodegradable‐Polymer Sirolimus‐Eluting Ultra‐Thin Stent

Catheterization and Cardiovascular Interventions, Volume 105, Issue 6, Page 1502-1509, May 1, 2025.
ABSTRACT Background There is limited evidence on the safety and efficacy of biodegradable‐polymer sirolimus‐eluting ultra‐thin stent (BP‐SES) in patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention (PCI). Aims This study aims to evaluate the clinical outcomes of HBR patients treated with BP‐SES and ≤ 30‐day dual ...
Andrea Erriquez, David M. Leistner, Valeria Paradies, Rita Pavasini, Matteo Serenelli, Gianni Casella, Simone Biscaglia, Christoph Naber, Gianluca Campo, Pieter C. Smits   +9 more
wiley   +1 more source

CLOPIDOGREL PHARMACOGENETICS

Рациональная фармакотерапия в кардиологии, 2016
Platelets play an important role in the pathogenesis of atherosclerosis. They are involved in atherosclerosis progression and thrombotic complications. That is why antiplatelet therapy is a necessary element of these complications prevention in patients ...
A. N. Meshkov
doaj   +1 more source

Successful Aspiration Thrombectomy for Cocaine‐Induced Right Coronary Artery Embolism Secondary to Left Ventricular Thrombus: A Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 5, May 2025.
ABSTRACT Coronary embolism (CE) is a rare yet significant contributor to acute myocardial infarction (AMI), particularly in younger patients. We report a 42‐year‐old male who experienced an AMI following recent cocaine use. Investigations revealed a left ventricular apical thrombus, identified as the source of a distal embolus occluding the right ...
Abraam Rezkalla, Ahmad Nouri, Fadi Hadya, Islam Rajab, Emile Doss   +4 more
wiley   +1 more source

Consolidation of P2Y12 Testing While Maintaining Quality and Turnaround Time [PDF]

, 2017
Objective: To consolidate the test performed at 2 different locations at 1, thereby improving cost effectiveness while maintaining quality and result turnaround time.https://jdc.jefferson.edu/patientsafetyposters/1059/thumbnail ...
Gong, MD, Jerald Z., Jagannathan, MBBS, Geetha   +1 more
core   +1 more source

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +2 more sources

Investigation of Genomic and Transcriptomic Risk Factors of Clopidogrel Response in African Americans

Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1313-1324, May 2025.
Clopidogrel, an anti‐platelet drug, is used to prevent thrombosis after percutaneous coronary intervention. Clopidogrel resistance results in recurring ischemic events, with African Americans (AA) suffering disproportionately. The aim of this study was to discover novel biomarkers of clopidogrel resistance in African Americans using genome and ...
Guang Yang, Cristina Alarcon, Catherine Chanfreau, Norman H. Lee, Paula Friedman, Edith Nutescu, Matthew Tuck, Travis O'Brien, Li Gong, Teri E. Klein, Kyong‐Mi Chang, Philip S. Tsao, David O. Meltzer, Julie A. Lynch, Million Veteran Program, Sony Tuteja, Minoli A. Perera   +16 more
wiley   +1 more source

Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders [PDF]

, 2018
Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel.
Adamany J, Bath PM, May J, Flaherty K, Woodhouse LJ, Dovlatova N, Fox SC, England TJ, Krishnan K, Robinson TG, Sprigg N, et al., Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Flaherty K, Havard D, et al., Cardoso RN, Benjo AM, DiNicolantonio JJ, Garcia DC, Macedo FY, El-Hayek G, Nadkarni GN, Gili S, Iannaccone M, Konstantinidis I, et al., Dovlatova N, Fox SC, May JA, Dovlatova N, Glenn JR, Johnson A, White AE, Radhakrishnan A, Heptinstall S., Heptinstall S, Heptinstall S, Heptinstall S, Jane May, Laohathai P, Joshi R, Radhakrishnan A, May J, Dovlatova N, Heptinstall S, Fox S., May J, Philip M Bath, Stan Heptinstall, TARDIS Trial Investigators, Krishnan K, Beridze M, Christensen H, Dineen R, Duley L, Heptinstall S, James M, Markus H, Pocock S, et al., Vlachojannis G   +15 more
core   +2 more sources

Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches

PROTEOMICS, EarlyView.
Paul Perco, Matthias Ley, Kinga Kęska‐Izworska, Dorota Wojenska, Enrico Bono, Samuel M. Walter, Lucas Fillinger, Klaus Kratochwill   +7 more
wiley   +1 more source