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The present state of aspirin and clopidogrel resistance [PDF]
Hämostaseologie, 2009 SummaryAntiplatelet therapy has demonstrated significant clinical benefit in the treatment of acute coronary syndrome. However, as with any treatment strategy it has been unable to prevent all cardiovascular events. This is far from surprising when considering the complexity of arterial thrombosis and more specifically platelet physiology. This lack of
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Clopidogrel Resistance: Pharmacokinetic or Pharmacogenetic?
The Journal of Clinical Pharmacology, 2009Clopidogrel is important for the management of acute coronary syndromes and, along with aspirin, is recommended in the American College of Cardiology/American Heart Association guideline. It is also used along with aspirin, during the placement of coronary artery stents.
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Clopidogrel Resistance: Implications for Coronary Stenting
Current Pharmaceutical Design, 2006Clopidogrel, in combination wih aspirin, is currently the drug of choice to prevent thrombosis after coronary stent implantation. Currently, clopidogrel is administered to the vast majority of patients without any assessment of platelet inhibition. Response variability and resistance, however, definitely occur to clopidogrel treatment. Preliminary data
Kevin P. Bliden +3 more
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International Journal of Clinical Pharmacy, 2015
A double maintenance dose of clopidogrel at 150 mg daily has been suggested as an effective alternative treatment for patients who have clopidogrel resistance.To determine if a double maintenance dose of clopidogrel can overcome the low drug response rate observed in patients who have clopidogrel resistance while on a 75 mg daily standard maintenance ...
JiHyeon Ryu +4 more
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A double maintenance dose of clopidogrel at 150 mg daily has been suggested as an effective alternative treatment for patients who have clopidogrel resistance.To determine if a double maintenance dose of clopidogrel can overcome the low drug response rate observed in patients who have clopidogrel resistance while on a 75 mg daily standard maintenance ...
JiHyeon Ryu +4 more
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Clopidogrel Response Variability, Resistance, or Both?
The American Journal of Cardiology, 2006Dual antiplatelet therapy represents an important advance for patients with established cardiovascular disease. Variable platelet response and potential resistance to therapy have emerged with aspirin and clopidogrel. There is no clear and accepted definition of clopidogrel resistance, but patients with lower responses to clopidogrel are at risk for ...
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Adrenoreceptors, platelet reactivity and clopidogrel resistance
Thrombosis and Haemostasis, 2008Thromb Haemost 2008; 100: 729–730 Platelet activation plays a central role in haemostasis and thrombosis. Antiplatelet therapy is considered to be the ‘cornerstone’in the prevention and treatment of thrombotic diseases such as coronary artery disease (CAD), stroke and peripheral arterial disease (PAD).
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Personalized medicine for clopidogrel resistance?
Nature Reviews Cardiology, 2009The benefits of clopidogrel in the treatment and prevention of coronary artery disease vary among patients. Studies have identified predictive markers of poor response to clopidogrel that might allow risk stratification of patients. Are we ready to enter the age of personalized medicine?
Valentin Fuster, Jean-Sébastien Hulot
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Clopidogrel resistance / Clopidogrel-Resistenz
LaboratoriumsMedizin, 2006Meinrad Gawaz, Tobias Geisler
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Evaluation of clopidogrel resistance
Thrombosis Research, 2005Peter Mossop +3 more
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