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Clopidogrel Resistance: Fact and Fiction
Future Cardiology, 2006The antiplatelet agent clopidogrel in combination with aspirin has been shown to reduce thrombotic events in patients with acute coronary syndromes and/or who are undergoing percutaneous coronary intervention. However, a large interindividual response variability to clopidogrel has been described.
J W, van Werkum +4 more
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Thienopyridines in cardiovascular disease: Focus on Clopidogrel resistance
Thrombosis and Haemostasis, 2007SummaryPlatelets play an important role in atherothrombotic disease, as well as in the pathogenesis of atherosclerosis and in complications. Antiplatelet therapy with Clopidogrel represents at present an important treatment of coronary artery disease (CAD), especially in and after acute coronary syndromes (ACS), and after coronary interventions when ...
Jolanta M Siller-Matula, Johann Wojta
exaly +3 more sources
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2009
Platelets play a critical role in pathogenesis of atherothrombotic diseases such as acute coronary syndromes and ischemic stroke. Clopidogrel, a thienopyridine derivative is an effective antiplatelet drug mostly used in combination with aspirin or as a single drug in aspirin intolerant patients.
Yeşim, Güray +2 more
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Platelets play a critical role in pathogenesis of atherothrombotic diseases such as acute coronary syndromes and ischemic stroke. Clopidogrel, a thienopyridine derivative is an effective antiplatelet drug mostly used in combination with aspirin or as a single drug in aspirin intolerant patients.
Yeşim, Güray +2 more
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Clopidogrel Resistance: Implications for Coronary Stenting
Current Pharmaceutical Design, 2006Clopidogrel, in combination wih aspirin, is currently the drug of choice to prevent thrombosis after coronary stent implantation. Currently, clopidogrel is administered to the vast majority of patients without any assessment of platelet inhibition. Response variability and resistance, however, definitely occur to clopidogrel treatment. Preliminary data
Paul A, Gurbel +3 more
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Clopidogrel Resistance: Pharmacokinetic or Pharmacogenetic?
The Journal of Clinical Pharmacology, 2009Clopidogrel is important for the management of acute coronary syndromes and, along with aspirin, is recommended in the American College of Cardiology/American Heart Association guideline. It is also used along with aspirin, during the placement of coronary artery stents.
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Clopidogrel Response Variability, Resistance, or Both?
The American Journal of Cardiology, 2006Dual antiplatelet therapy represents an important advance for patients with established cardiovascular disease. Variable platelet response and potential resistance to therapy have emerged with aspirin and clopidogrel. There is no clear and accepted definition of clopidogrel resistance, but patients with lower responses to clopidogrel are at risk for ...
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The present state of aspirin and clopidogrel resistance
Hämostaseologie, 2009SummaryAntiplatelet therapy has demonstrated significant clinical benefit in the treatment of acute coronary syndrome. However, as with any treatment strategy it has been unable to prevent all cardiovascular events. This is far from surprising when considering the complexity of arterial thrombosis and more specifically platelet physiology. This lack of
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Adrenoreceptors, platelet reactivity and clopidogrel resistance
Thrombosis and Haemostasis, 2008Thromb Haemost 2008; 100: 729–730 Platelet activation plays a central role in haemostasis and thrombosis. Antiplatelet therapy is considered to be the ‘cornerstone’in the prevention and treatment of thrombotic diseases such as coronary artery disease (CAD), stroke and peripheral arterial disease (PAD).
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Promising clopidogrel analogs may overcome clopidogrel resistance: 2025 update
Biochemical PharmacologyClopidogrel is one of the World Health Organization-recommended essential medicines used for antiplatelet therapy. However, its usage is limited by resistance of certain patients to clopidogrel. Herein, we systematically summarized promising novel analogs of clopidogrel and evaluated their preclinical and clinical properties as well as the science ...
Hong-Guang Xie +5 more
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Evaluation of clopidogrel resistance
Thrombosis Research, 2005Zakaria Ali, Almsherqi +3 more
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