Results 171 to 180 of about 30,781 (201)
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Clinical implications of clopidogrel resistance
Thrombosis and Haemostasis, 2008SummaryThe benefits of clopidogrel in the treatment and prevention of coronary artery disease are well established, however, not all individuals respond in the same way to clopidogrel; there are patients who suffer adverse events despite clopidogrel treatment.
Antonio De Miguel +2 more
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Aspirin and Clopidogrel Resistance
Hematology, 2007AbstractAspirin and clopidogrel provide significant clinical benefit in patients with cardiovascular disease. However, given the complexity of platelet activation, it is not surprising that aspirin or clopidogrel prevent a small proportion of cardiovascular events.
Desmond J, Fitzgerald, Andrew, Maree
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Clopidogrel resistance: A diagnostic challenge
International Journal of Cardiology, 2009No clear and generally accepted definition of clopidogrel resistance has been achieved up to now. We believe that the new point-of-care assays of platelet function may help the clinicians to overcome to define clopidogrel resistance especially in patients undergoing percutaneous coronary intervention in whom the level of inhibition of platelets is ...
Turgay, Celik +3 more
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The “Clopidogrel Resistance” Trap
The American Journal of Cardiology, 2007a p w b e p “ S b s “ t a s i n i v t p m d e o n s u a b o b b S f d v r p e w a a ( r d p d Q v f t o w o Numerous randomized trials have indicated the benefits f clopidogrel either as an alternative1 or as an adjunct2 to spirin for the secondary prevention of acute vascular vents, including absolute mortality reduction in the largest ver acute ...
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Clopidogrel Resistance: Fact and Fiction
Future Cardiology, 2006The antiplatelet agent clopidogrel in combination with aspirin has been shown to reduce thrombotic events in patients with acute coronary syndromes and/or who are undergoing percutaneous coronary intervention. However, a large interindividual response variability to clopidogrel has been described.
J W, van Werkum +4 more
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Clopidogrel Resistance: Pharmacokinetic or Pharmacogenetic?
The Journal of Clinical Pharmacology, 2009Clopidogrel is important for the management of acute coronary syndromes and, along with aspirin, is recommended in the American College of Cardiology/American Heart Association guideline. It is also used along with aspirin, during the placement of coronary artery stents.
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Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2009
Platelets play a critical role in pathogenesis of atherothrombotic diseases such as acute coronary syndromes and ischemic stroke. Clopidogrel, a thienopyridine derivative is an effective antiplatelet drug mostly used in combination with aspirin or as a single drug in aspirin intolerant patients.
Yeşim, Güray +2 more
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Platelets play a critical role in pathogenesis of atherothrombotic diseases such as acute coronary syndromes and ischemic stroke. Clopidogrel, a thienopyridine derivative is an effective antiplatelet drug mostly used in combination with aspirin or as a single drug in aspirin intolerant patients.
Yeşim, Güray +2 more
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Clopidogrel Resistance: Implications for Coronary Stenting
Current Pharmaceutical Design, 2006Clopidogrel, in combination wih aspirin, is currently the drug of choice to prevent thrombosis after coronary stent implantation. Currently, clopidogrel is administered to the vast majority of patients without any assessment of platelet inhibition. Response variability and resistance, however, definitely occur to clopidogrel treatment. Preliminary data
Paul A, Gurbel +3 more
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The present state of aspirin and clopidogrel resistance
Hämostaseologie, 2009SummaryAntiplatelet therapy has demonstrated significant clinical benefit in the treatment of acute coronary syndrome. However, as with any treatment strategy it has been unable to prevent all cardiovascular events. This is far from surprising when considering the complexity of arterial thrombosis and more specifically platelet physiology. This lack of
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Adrenoreceptors, platelet reactivity and clopidogrel resistance
Thrombosis and Haemostasis, 2008Thromb Haemost 2008; 100: 729–730 Platelet activation plays a central role in haemostasis and thrombosis. Antiplatelet therapy is considered to be the ‘cornerstone’in the prevention and treatment of thrombotic diseases such as coronary artery disease (CAD), stroke and peripheral arterial disease (PAD).
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