Results 81 to 90 of about 529,491 (346)
Biological PsychiatryIn the same way that beauty lies in the eye of the beholder, what a stimulus does to the brain is determined not simply by the nature of the stimulus but by the nature of the brain that is receiving the stimulus at that instant in time. Over the past decades, therapeutic brain stimulation has typically applied open-loop fixed protocols and has largely ...
Zrenner, Christoph, Ziemann, Ulf
openaire +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Closed-Loop Control of a Piezo-Fluidic Amplifier
, 2020 Fluidic valves based on the Coand\u{a} effect are increasingly being considered for use in aerodynamic flow control applications. A limiting factor is their variation in switching time, which often precludes their use.
Bacic, Marko, Nicholls, Chris
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Closed — Loop differential games [PDF]
, 1975 The object of this report is closed-loop differential games which are a formalization of problems in dynamics related to control in presence of uncertainty or conflict. Under the game-theoretic approach to the problem we assume that the uncontrollable factors may appear to be most unfavourable from the point of view of one or the other criterion ...
openaire +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Penerapan Kendali Fuzzy dalam Pengembangan Stimulasi Listrik untuk Mempercepat Penyembuhan Luka
Jurnal Nasional Teknik Elektro dan Teknologi InformasiPenyembuhan luka kronis masih menjadi tantangan medis karena keterbatasan terapi konvensional dalam mempercepat regenerasi jaringan. Stimulasi listrik (electrical stimulation, ES) dapat menjadi solusi efektif, tetapi ES open-loop belum mampu menyesuaikan
Rahmawati +5 more
doaj +1 more source