Results 91 to 100 of about 32,937 (264)

Pharmacokinetic and pharmacodynamic evaluation of sulbactam‐durlobactam in a critically ill patient on continuous venovenous hemofiltration infected with carbapenem‐resistant Acinetobacter baumannii‐calcoaceticus complex

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Background Drug databases currently do not provide dosing guidance for sulbactam‐durlobactam in continuous renal replacement therapy. Herein, we present the first in vivo pharmacokinetic (PK) evaluation of sulbactam‐durlobactam during continuous venovenous hemofiltration (CVVH) in a patient with carbapenem‐resistant Acinetobacter baumannii ...
Wesley D. Kufel, Nabil Zeineddine, Aliaa Fouad, Hanna F. Roenfanz, Ryan K. Shields, Ellen G. Kline, Jameson Warner, Kathleen Hanrahan, Joseph L. Kuti   +8 more
wiley   +1 more source

Quantification of Clostridioides (Clostridium) difficile in feces of calves of different age and determination of predominant Clostridioides difficile ribotype 033 relatedness and transmission between family dairy farms using multilocus variable-number tandem-repeat analysis

BMC Veterinary Research, 2018
Background Community acquired Clostridioides (Clostridium) difficile infection (CA-CDI) is a significant health problem in human and veterinary medicine. Animals are often considered as potential reservoirs for CA-CDI.
Petra Bandelj, Céline Harmanus, Rok Blagus, Marko Cotman, Ed J. Kuijper, Matjaz Ocepek, Modest Vengust   +6 more
doaj   +1 more source

Proton pump inhibitor concomitant use to prevent oxaliplatin‐induced peripheral neuropathy: Clinical retrospective cohort study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Background Oxaliplatin‐induced peripheral neuropathy (OIPN) is a major clinical challenge because it leads to discontinuation of chemotherapy. Omeprazole, a proton pump inhibitor (PPI), has been shown to prevent OIPN in a rat model. Therefore, we aimed to test whether the concomitant use of a PPI reduces oxaliplatin discontinuation due to OIPN.
Keisuke Mine, Takehiro Kawashiri, Kohei Mori, Yusuke Mori, Haruna Ishida, Hibiki Kudamatsu, Shunsuke Fujita, Mayako Uchida, Takaaki Yamada, Nobuaki Egashira, Ichiro Ieiri, Satoru Koyanagi, Shigehiro Ohdo, Takao Shimazoe, Daisuke Kobayashi   +14 more
wiley   +1 more source

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

Nature Communications, 2021
The effects of antibiotics on the gut microbiota can lead to enhanced colonization of Clostridioides difficile (C. difficile) and toxin-mediated pathogenesis.
Joshua R. Fletcher, Colleen M. Pike, Ruth J. Parsons, Alissa J. Rivera, Matthew H. Foley, Michael R. McLaren, Stephanie A. Montgomery, Casey M. Theriot   +7 more
doaj   +1 more source

Case Studies of Orphan Domain Reclassification in ECOD by Expert Curation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Homology‐based protein domain classification is a powerful tool for gaining biological insights into protein function. This classification process has been significantly enhanced by the availability of experimental structures and high‐accuracy structural models generated by advanced tools such as AlphaFold.
Jimin Pei, R. Dustin Schaeffer, Qian Cong, Nick V. Grishin   +3 more
wiley   +1 more source

Whole genome sequence analysis reveals limited diversity among Clostridioides difficile ribotype 027 and 078 isolates collected in 22 hospitals in Berlin and Brandenburg, Germany

Antimicrobial Resistance and Infection Control
Background Clostridioides difficile infections (CDI) present significant health risks and are among the most important nosocomial infections. Ribotype (RT) 027 poses a particular risk due to its proposed “hypervirulence”. Traditionally, C.
Esther E. Dirks, Vanessa Pfiffer, Genevieve Sohl, Fabian K. Berger, Ina Friesen, Johannes Friesen, Ralf Ignatius, Johannes Elias, Alexander Mellmann, Mardjan Arvand   +9 more
doaj   +1 more source

Gut Microbial Signatures Associated With Clinical Remission in Inflammatory Bowel Disease Treated With Biologics: A Comprehensive Multi‐Cohort Analysis

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background and Aims The relationship between gut microbiota and biological treatment response in inflammatory bowel disease (IBD) remains incompletely understood. We sought to characterize microbial signatures associated with clinical remission and develop a prediction model for clinical remission. Methods We analyzed 16 S rRNA gene sequencing
Qingyang Zheng, Yun Zhong, Haifeng Lian, Jieru Zhuang, Lichun Wang, Jianyong Chen, Huaiming Wang, Hui Wang, Xijie Ye, Zicheng Huang, Keli Yang   +10 more
wiley   +1 more source

Management of Clostridioides difficile infection: an Italian Delphi consensus [PDF]

Background: Clostridioides difficile infection (CDI), a leading cause of nosocomial deaths, is a microbiota-mediated disease. As such, the use of broader spectrum antibiotics, such as vancomycin and metronidazole, can prime the gastrointestinal tract to ...
De Rosa, Francesco Giuseppe
core   +4 more sources

Successful treatment of Pseudescherichia vulneris‐associated acute haemorrhagic diarrhoea with a single faecal microbiota transplantation in a dog

Veterinary Record Case Reports, EarlyView.
Abstract An 8‐year‐4‐month‐old, female, neutered labrador retriever with acute haemorrhagic diarrhoea was unresponsive to symptomatic and antibiotic treatment, and developed gastrointestinal protein loss leading to significant hypoalbuminaemia.
Luis Miguel Garcia Roldan, Glynn Woods, Julien Dandrieux, Silke Salavati Schmitz   +3 more
wiley   +1 more source

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source