Results 11 to 20 of about 34,117 (261)

Clostridioides difficile infection: are the three currently used antibiotic treatment options equal from pharmacological and microbiological points of view?

International Journal of Infectious Diseases, 2022
Recently, the recommendations for the treatment of Clostridioides difficile infection (CDI) have been updated. However, in addition to the clinical efficacy data, the drug of choice should ideally represent optimal antimicrobial stewardship, with an ...
Marcela Krutova, Mark Wilcox, Ed Kuijper
doaj   +1 more source

Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records

Frontiers in Immunology, 2021
BackgroundClostridioides difficile is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to Clostridioides difficile infection has not been studied on a large-scale.MethodsA total of 1,160 Clostridioides ...
Jiang Li, Yanfei Zhang, Alexandria L. Jilg, Donna M. Wolk, Harshit S. Khara, Amy Kolinovsky, David D. K. Rolston, Raquel Hontecillas, Josep Bassaganya-Riera, Marc S. Williams, Vida Abedi, Ming Ta Michael Lee   +11 more
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Editorial: Clostridioides difficile infection

Frontiers in Medicine
Guido Granata, Frédéric Barbut, Nicola Petrosillo   +2 more
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Clostridioides difficile [PDF]

Trends in Microbiology, 2018
Clostridioides difficile is a spore-forming, anaerobic, intestinal pathogen that causes severe diarrhea that can lead to death. In 2011, C. difficile infected ∼500000 people in the USA and killed ∼29000 people. C. difficile infection (CDI) is the most common healthcare-related infection in the USA, leading to increased healthcare costs of $4.8 billion.
Brindar K, Sandhu, Shonna M, McBride
openaire   +2 more sources

Persistent systemic microbial translocation, inflammation, and intestinal damage during Clostridioides difficile infection [PDF]

, 2020
Background. Clostridioides difficile infection (CDI) might be complicated by the development of nosocomial bloodstream infection (n-BSI). Based on the hypothesis that alteration of the normal gut integrity is present during CDI, we evaluated markers of ...
Aversano, L., Battaglia, R., Bruno, G., Ciardi, M. R., Corazziari, E. S., de Angelis, M., Iera, J., Mascellino, M. T., Mastroianni, C. M., Miele, M. C., Morelli, S., Oliva, A., Venditti, M., Vullo, V.   +13 more
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Diagnostic Methods of Clostridioides difficile Infection and Clostridioides difficile Ribotypes in Studied Sample [PDF]

Antibiotics, 2021
Background: Clostridioides (Clostridium) difficile is the most common nosocomial pathogen and antibiotic-related diarrhea in health-care facilities. Over the last few years, there was an increase in the incidence rate of C. difficile infection cases in Slovakia.
Elena Novakova, Zuzana Stofkova, Vladimira Sadlonova, Lukas Hleba   +3 more
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Molecular epidemiology and antimicrobial resistance of Clostridioides difficile detected in chicken, soil and human samples from Zimbabwe

International Journal of Infectious Diseases, 2020
Background: Clostridioides difficile is the major cause of infectious nosocomial diarrhoea in industrialized nations. Data on the occurrence of C. difficile in Africa, ribotype (RT) distribution, antimicrobial susceptibility patterns and potential ...
Fabian K. Berger, Alexander Mellmann, Markus Bischoff, Lutz von Müller, Sören L. Becker, Clifford Simango, Barbara Gärtner   +6 more
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IL-27 induces LL-37/CRAMP expression from intestinal epithelial cells: implications for immunotherapy of Clostridioides difficile infection

Gut Microbes, 2021
Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory
Banglao Xu, Xianan Wu, Yi Gong, Ju Cao
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Epidemiology of Clostridioides difficile Infection in Portugal: A Retrospective, Observational Study of Hospitalized Patients

Acta Médica Portuguesa, 2022
Introduction: Clostridioides difficile is the main cause of healthcare-associated diarrhea in Europe and North America. The aim of this study was to characterize the epidemiology and clinical burden of Clostridioides difficile infection among ...
Cláudia Nazareth, Inês Leitão, Ernestina Reis, Hugo Inácio, Filomena Martins, Elmano Ramalheira, Flávia Cunha, Carla Santos, Sara Lino, Hugo Moreira, Nadiya Kruptsala, Andrea Santos, Laura Paixão, Leonor Pássaro, Mónica Oleastro   +14 more
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Iron Regulation in Clostridioides difficile [PDF]

Frontiers in Microbiology, 2018
The response to iron limitation of several bacteria is regulated by the ferric uptake regulator (Fur). The Fur-regulated transcriptional, translational and metabolic networks of the Gram-positive, pathogen Clostridioides difficile were investigated by a combined RNA sequencing, proteomic, metabolomic and electron microscopy approach.
Mareike Berges, Annika-Marisa Michel, Christian Lassek, Aaron M. Nuss, Michael Beckstette, Petra Dersch, Katharina Riedel, Susanne Sievers, Dörte Becher, Andreas Otto, Sandra Maaß, Manfred Rohde, Denitsa Eckweiler, Jose M. Borrero-de Acuña, Martina Jahn, Meina Neumann-Schaal, Dieter Jahn, Dieter Jahn   +17 more
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