Results 11 to 20 of about 25,087 (168)

Engineering probiotics to inhibit Clostridioides difficile infection by dynamic regulation of intestinal metabolism

Nature Communications, 2022
Clostridioides difficile infection (CDI) results in significant morbidity and mortality in hospitalised patients. Here the authors engineer probiotics to restore intestinal bile salt metabolism in response to antibiotic-induced microbiome dysbiosis ...
Elvin Koh, In Young Hwang, Hui Ling Lee, Ryan De Sotto, Jonathan Wei Jie Lee, Yung Seng Lee, John C. March, Matthew Wook Chang   +7 more
doaj   +1 more source

In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden

Microbiology Spectrum, 2021
Clostridioides difficile infection represents a growing clinical challenge. The new compound omadacycline is a potential treatment alternative, as many antibiotics have limited activity or are rarely used due to costs and side effects.
Angela Camporeale, Chaitanya Tellapragada, Jelena Kornijenko, Carl Erik Nord, Christian G. Giske   +4 more
doaj   +1 more source

Analysis of the impact of secondary prophylaxis on recurrence in critically ill adults

SAGE Open Medicine, 2020
Introduction: Clostridioides (formerly Clostridium ) difficile infection recurrence in patients re-exposed to antibiotics for treatment of a non- Clostridioides difficile infection is high at approximately 33%. Low-dose per os vancomycin (e.g. 125 mg q12 
Kathryn A Connor, Kelly M Conn
doaj   +1 more source

Clostridioides Difficile Enteritis: Case Report and Literature Review

Antibiotics, 2022
Background: Clostridioides Difficile is a well-known pathogen causing diarrhea of various degrees of severity through associated infectious colitis.
Artsiom Klimko, Cristian George Tieranu, Ana-Maria Curte, Carmen Monica Preda, Ioana Tieranu, Andrei Ovidiu Olteanu, Elena Mirela Ionescu   +6 more
doaj   +1 more source

Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection

Gut Pathogens, 2021
Background Clostridioides difficile infection (CDI) is an infectious nosocomial disease caused by Clostridioides difficile, an opportunistic pathogen that occurs in the intestine after extensive antibiotic regimens. Results Nine C.
Seung Woo Ahn, Se Hee Lee, Uh Jin Kim, Hee-Chang Jang, Hak-Jong Choi, Hyon E. Choy, Seung Ji Kang, Seong Woon Roh   +7 more
doaj   +1 more source

Rare Clinical Association between Clostridioides difficile Infection and Ischemic Colitis: Case Report and Literature Review

Medicina, 2021
Background and Objectives: Gut microbiota plays an important role in the wellbeing of the host through different interactions between microflora constituents. In certain instances, Clostridioides difficile may pullulate, causing infection with associated
Elena Mirela Ionescu, Ana-Maria Curte, Andrei Ovidiu Olteanu, Carmen Monica Preda, Ioana Tieranu, Artsiom Klimko, Cristian George Tieranu   +6 more
doaj   +1 more source

Extraintestinal Clostridioides difficile infection

IDCases, 2020
Clostridioides (Clostridium) difficile is the major cause of healthcare antibiotic-associated diarrhoea. However, extra-intestinal manifestations of Clostridioides (Clostridium) difficile infection (CDI) (including bacteremia and tissue infection) are ...
Zhao Hai, Lei Peng Zhen, Ma Juan, Yang Fan, Cang Jin Rong, Liang Jing Yao, Zhang Li Xia   +6 more
doaj   +1 more source

Novel Drivers of Virulence in Clostridioides difficile Identified via Context-Specific Metabolic Network Analysis

mSystems, 2021
Clostridioides difficileC ...
Matthew L. Jenior, Jhansi L. Leslie, Deborah A. Powers, Elizabeth M. Garrett, Kimberly A. Walker, Mary E. Dickenson, William A. Petri, Rita Tamayo, Jason A. Papin   +8 more
doaj   +1 more source

Gut Microbiota Diversity of Preterm Neonates Is Associated With Clostridioides Difficile Colonization

Frontiers in Cellular and Infection Microbiology, 2022
In adults, Clostridioides difficile infections are associated with alterations of the intestinal bacterial populations. Although preterm neonates (PN) are frequently colonized by C. difficile, limited data are available regarding the relationship between
Jeanne Couturier, Jeanne Couturier, Patricia Lepage, Sarah Jolivet, Johanne Delannoy, Victoria Mesa, Pierre-Yves Ancel, Pierre-Yves Ancel, Jean-Christophe Rozé, Marie-José Butel, Frédéric Barbut, Frédéric Barbut, Frédéric Barbut, Julio Aires   +13 more
doaj   +1 more source

Evaluation of three commercial rapid immunoassays for the diagnosis of Clostridioides difficile infection

Microbiology Spectrum
Current guidelines recommend the use of a two-step algorithm for the laboratory diagnosis of Clostridioides difficile infection (CDI). Several commercial rapid immunoassays that detect both GDH and toxin A/B in stool samples are available and could be ...
Hannes Bjarki Vigfússon, Theresa Ennefors, Torbjörn Norén, Martin Sundqvist   +3 more
doaj   +1 more source