Results 41 to 50 of about 171,697 (237)

Possible contribution of shoes to clostridioides difficile transmission within hospitals [PDF]

, 2020
Clostridioides difficile remains the most common cause of healthcare-associated intestinal infection. Hospitalized patients aged >65 years and receiving antibiotic therapy are the population most at risk of C. difficile infection (CDI)
Blazevic, Ines, Bozena Kotnik Kevorkijan, Maja Rupnik, Sandra Janezic, Ines Blazevic, Tatjana Remec, Janezic, Sandra, Kotnik Kevorkijan, Bozena, Remec, Tatjana, Rupnik, Maja, David W. Eyre, Eyre, David W   +11 more
core   +1 more source

Stabilizing Functional Nucleic Acids for Real‐Sample Diagnostics

Angewandte Chemie, EarlyView.
Functional nucleic acids enable programmable real‐sample diagnostics, but often lose function in complex biological matrices. This review highlights four stabilization levers—chemical, topological, architectural, and microenvironment/interface engineering—that preserve aptamer and DNAzyme performance in saliva, serum, urine, and stool, reframing ...
Soyeon Lee, Letizia Dondi, Amal Mathai, Connor Nurmi, Yingfu Li   +4 more
wiley   +2 more sources

Evaluation of the STANDARD M10 and Xpert C. difficile assays for the detection of toxigenic Clostridioides difficile in stools

Microbiology Spectrum
This study aims to compare the sensitivity and specificity of two Nucleic Acid Amplification Tests (NAATs), the STANDARD M10 Clostridioides difficile (M10) and the Xpert C. difficile (Xpert) assays, for the detection of toxigenic C.
Y. Roukoz-Diab, M. Ehmig, S. Luce, C. Eckert, S. Timsit, J. Couturier, I. Mostaghat, F. Barbut   +7 more
doaj   +1 more source

Evaluation of three commercial rapid immunoassays for the diagnosis of Clostridioides difficile infection

Microbiology Spectrum
Current guidelines recommend the use of a two-step algorithm for the laboratory diagnosis of Clostridioides difficile infection (CDI). Several commercial rapid immunoassays that detect both GDH and toxin A/B in stool samples are available and could be ...
Hannes Bjarki Vigfússon, Theresa Ennefors, Torbjörn Norén, Martin Sundqvist   +3 more
doaj   +1 more source

Pathogenicity and virulence of Clostridioides difficile

Virulence, 2023
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhea, and is responsible for a spectrum of diseases characterized by high levels of recurrence, morbidity, and mortality. Treatment is complex, since antibiotics constitute both the main treatment and the major risk factor for infection.
Jessica E. Buddle, Robert P. Fagan
openaire   +4 more sources

Novel Drivers of Virulence in Clostridioides difficile Identified via Context-Specific Metabolic Network Analysis

mSystems, 2021
Clostridioides difficileC ...
Matthew L. Jenior, Jhansi L. Leslie, Deborah A. Powers, Elizabeth M. Garrett, Kimberly A. Walker, Mary E. Dickenson, William A. Petri, Rita Tamayo, Jason A. Papin   +8 more
doaj   +1 more source

Not Testing for Clostridioides difficile: Missing the Diagnosis, Treatment and Isolation

, 2023
Restrictive testing for Clostridioides difficile has negative consequences.
Clifford Wlodaver (11477712)
core   +1 more source

Clostridioides difficile, a New “Superbug”

Microorganisms, 2023
Clostridioides difficile is a Gram-positive, spore-forming, anaerobic bacterium. The clinical features of C. difficile infections (CDIs) can vary, ranging from the asymptomatic carriage and mild self-limiting diarrhoea to severe and sometimes fatal pseudomembranous colitis. C.
Rumyana Markovska, Georgi Dimitrov, Raina Gergova, Lyudmila Boyanova   +3 more
openaire   +3 more sources

Gut Microbiota Diversity of Preterm Neonates Is Associated With Clostridioides Difficile Colonization

Frontiers in Cellular and Infection Microbiology, 2022
In adults, Clostridioides difficile infections are associated with alterations of the intestinal bacterial populations. Although preterm neonates (PN) are frequently colonized by C. difficile, limited data are available regarding the relationship between
Jeanne Couturier, Jeanne Couturier, Patricia Lepage, Sarah Jolivet, Johanne Delannoy, Victoria Mesa, Pierre-Yves Ancel, Pierre-Yves Ancel, Jean-Christophe Rozé, Marie-José Butel, Frédéric Barbut, Frédéric Barbut, Frédéric Barbut, Julio Aires   +13 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source