Results 51 to 60 of about 143,361 (253)

Evaluation of the STANDARD M10 and Xpert C. difficile assays for the detection of toxigenic Clostridioides difficile in stools

Microbiology Spectrum
This study aims to compare the sensitivity and specificity of two Nucleic Acid Amplification Tests (NAATs), the STANDARD M10 Clostridioides difficile (M10) and the Xpert C. difficile (Xpert) assays, for the detection of toxigenic C.
Y. Roukoz-Diab, M. Ehmig, S. Luce, C. Eckert, S. Timsit, J. Couturier, I. Mostaghat, F. Barbut   +7 more
doaj   +1 more source

A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance

Cell Host and Microbe
SUMMARY Clostridioides difficile, a major cause of antibiotic-associated diarrhea, is suppressed by the gut microbiome, but the precise mechanisms are not fully described.
Shuchang Tian, Min Soo Kim, Jingcheng Zhao, Kerim Heber, Fuhua Hao, David Koslicki, Sangshan Tian, Vishal Singh, A. Patterson, J. Bisanz   +9 more
semanticscholar   +1 more source

Evaluation of three commercial rapid immunoassays for the diagnosis of Clostridioides difficile infection

Microbiology Spectrum
Current guidelines recommend the use of a two-step algorithm for the laboratory diagnosis of Clostridioides difficile infection (CDI). Several commercial rapid immunoassays that detect both GDH and toxin A/B in stool samples are available and could be ...
Hannes Bjarki Vigfússon, Theresa Ennefors, Torbjörn Norén, Martin Sundqvist   +3 more
doaj   +1 more source

Gut Microbiota Diversity of Preterm Neonates Is Associated With Clostridioides Difficile Colonization

Frontiers in Cellular and Infection Microbiology, 2022
In adults, Clostridioides difficile infections are associated with alterations of the intestinal bacterial populations. Although preterm neonates (PN) are frequently colonized by C. difficile, limited data are available regarding the relationship between
Jeanne Couturier, Jeanne Couturier, Patricia Lepage, Sarah Jolivet, Johanne Delannoy, Victoria Mesa, Pierre-Yves Ancel, Pierre-Yves Ancel, Jean-Christophe Rozé, Marie-José Butel, Frédéric Barbut, Frédéric Barbut, Frédéric Barbut, Julio Aires   +13 more
doaj   +1 more source

Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model

Msphere
Treatment with antibiotics is a major risk factor for Clostridioides difficile infection, likely due to depletion of the gastrointestinal microbiota. Two microbiota-mediated mechanisms thought to limit C.
Xiaoyun Huang, April E. Johnson, Joshua N. Brehm, Thi Van Thanh Do, T. Auchtung, Hugh McCullough, Armando I. Lerma, S. Haidacher, Kathleen M. Hoch, Thomas D. Horvath, Joseph A. Sorg, Anthony M. Haag, JM Auchtung   +12 more
semanticscholar   +1 more source

Clostridioides difficile Flagella

International Journal of Molecular Sciences
Clostridioides difficile is an important pathogen for humans with a lead in nosocomial infection, but it is also more and more common in communities. Our knowledge of the pathology has historically been focused on the toxins produced by the bacteria that remain its major virulence factors.
Jean-Christophe Marvaud, Sylvie Bouttier, Johanna Saunier, Imad Kansau   +3 more
openaire   +2 more sources

Clostridioides difficile, a New “Superbug”

Microorganisms, 2023
Clostridioides difficile is a Gram-positive, spore-forming, anaerobic bacterium. The clinical features of C. difficile infections (CDIs) can vary, ranging from the asymptomatic carriage and mild self-limiting diarrhoea to severe and sometimes fatal pseudomembranous colitis. C.
Rumyana Markovska, Georgi Dimitrov, Raina Gergova, Lyudmila Boyanova   +3 more
openaire   +3 more sources

Effective Dosage of Oral Vancomycin in Treatment for Initial Episode of Clostridioides difficile Infection: A Systematic Review and Meta-Analysis

Antibiotics, 2019
Background: Oral vancomycin is a first line treatment for an initial episode of Clostridioides difficile infection. However, the comparative efficacy of different dosing regimens is lacking evidence in the current literature. Methods: We searched PubMed,
Chia-Yu Chiu, Amara Sarwal, Addi Feinstein, Karen Hennessey   +3 more
doaj   +1 more source

Epidemiology of Clostridioides difficile Infections in Germany, 2010–2019: A Review from Four Public Databases

Infectious Diseases and Therapy, 2023
Introduction Clostridioides difficile infection (CDI) is a recognized global threat especially for vulnerable populations. It is of particular concern to healthcare providers as it is found in both hospital and community settings, with severe courses ...
Gordon Brestrich, Frederick J. Angulo, Fabian K. Berger, Christian Brösamle, Stefan Hagel, Andreas Leischker, Christoph Lübbert, Friederike Maechler, Sophie-Susann Merbecks, Nadia Minarovic, Jennifer C. Moïsi, Lutz von Müller, Phillip A. Reuken, Thomas Weinke, Holly Yu, Alexander Mellmann   +15 more
doaj   +1 more source

Impact of Prophylactic Cefepime on Surgical Site Infection and Severe Morbidity in Patients Who Underwent Pancreaticoduodenectomy With Preoperative Biliary Drainage

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Although prophylactic broad‐spectrum antibiotics can reduce postoperative complications after pancreaticoduodenectomy (PD), the optimal regimen remains uncertain. This study evaluated the impact of prophylactic cefepime (CFPM) on surgical site infection (SSI) and severe morbidity after PD with preoperative biliary drainage.
Genki Watanabe, Akihiro Murata, Yu Kasamatsu, Atsushi Ishihara, Daisuke Nagashima, Tetsuzo Tashima, Shintaro Kodai, Akishige Kanazawa, Sadatoshi Shimizu   +8 more
wiley   +1 more source