Results 51 to 60 of about 168,874 (243)

Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre [PDF]

, 2022
Serious concerns have been raised about a possible increase in cases of Clostridioides difficile infection (CDI) during the COVID-19 pandemic. We conducted a retrospective observational single centre study which revealed that total combined community and
Hills, Tim, Crooks, Colin, Twitchell, Hannah, Clarkson, Annette, Montgomery, Ros, Monaghan, Tanya M., Abdic, Heather, Briggs, Steve, Voona, Sanjana   +8 more
core   +1 more source

Clostridioides difficile Flagella

International Journal of Molecular Sciences
Clostridioides difficile is an important pathogen for humans with a lead in nosocomial infection, but it is also more and more common in communities. Our knowledge of the pathology has historically been focused on the toxins produced by the bacteria that remain its major virulence factors.
Jean-Christophe Marvaud, Sylvie Bouttier, Johanna Saunier, Imad Kansau   +3 more
openaire   +2 more sources

Laboratory-Detected <i>Clostridioides difficile</i> Stool-Test Positivity and Mortality in Sepsis: A Retrospective Cohort Study. [PDF]

Health Sci Rep
ABSTRACT Background Sepsis disrupts intestinal microbiota, and broad‐spectrum antibiotics may worsen dysbiosis. Clostridioides difficile (C. difficile) infection (CDI) is a prevalent nosocomial enteric pathogen among critically ill patients, yet its prognostic implications in sepsis remain inadequately studied.
Hu J, Deng F, Hu T, Meng B, Deng S, Zhang L, Li W.   +6 more
europepmc   +2 more sources

Iron Regulation in Clostridioides difficile [PDF]

Frontiers in Microbiology, 2018
The response to iron limitation of several bacteria is regulated by the ferric uptake regulator (Fur). The Fur-regulated transcriptional, translational and metabolic networks of the Gram-positive, pathogen Clostridioides difficile were investigated by a combined RNA sequencing, proteomic, metabolomic and electron microscopy approach.
Mareike Berges, Annika-Marisa Michel, Christian Lassek, Aaron M. Nuss, Michael Beckstette, Petra Dersch, Katharina Riedel, Susanne Sievers, Dörte Becher, Andreas Otto, Sandra Maaß, Manfred Rohde, Denitsa Eckweiler, Jose M. Borrero-de Acuña, Martina Jahn, Meina Neumann-Schaal, Dieter Jahn, Dieter Jahn   +17 more
openaire   +5 more sources

Lab‐in‐a‐Tube System Integrating Hierarchically Wrinkled Electrodes and DNAzyme‐Functionalized Beads for Diagnosis of Clostridioides difficile Infection

Advanced Materials, EarlyView.
The point‐of‐care diagnosis of Clostridioides difficile infection remains challenging due to reliance on slow culture and amplification‐based methods. A lab‐in‐a‐tube electrochemical biosensor integrating DNAzymes, antifouling magnetic beads, and a hierarchically structured flow cell enables amplification‐ and culture‐free detection directly in stool ...
Survanshu Saxena, Soyeon Lee, Youngeun Choi, Jonathan L'Heureux‐Hache, Jiaying Liu, Sadman Sakib, Sara M. Imani, Marek Smieja, Yingfu Li, Todd Hoare, Leyla Soleymani   +10 more
wiley   +1 more source

Clostridioides difficile Infection [PDF]

Annals of Internal Medicine, 2018
Clostridioides difficile (formerly Clostridium difficile) infection is the most frequently identified health care-associated infection in the United States. C difficile has also emerged as a cause of community-associated diarrhea, resulting in increased incidence of community-associated infection.
Alice Y, Guh, Preeta K, Kutty
openaire   +2 more sources

Treating Clostridioides difficile: Could Microbiota-based Live Biotherapeutic Products Provide the Answer?

, 2023
Sandhya Nagarakanti, Robert Orenstein Division of Infectious Diseases, Mayo Clinic Arizona, Phoenix, AZ, USACorrespondence: Sandhya Nagarakanti, Mayo Clinic Arizona, Division of Infectious Diseases, 577 East Mayo Boulevard, Phoenix, AZ, 85054, USA, Tel ...
Nagarakanti S, Orenstein R
core  

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Epidemiology of Clostridioides difficile Infections in Germany, 2010–2019: A Review from Four Public Databases

Infectious Diseases and Therapy, 2023
Introduction Clostridioides difficile infection (CDI) is a recognized global threat especially for vulnerable populations. It is of particular concern to healthcare providers as it is found in both hospital and community settings, with severe courses ...
Gordon Brestrich, Frederick J. Angulo, Fabian K. Berger, Christian Brösamle, Stefan Hagel, Andreas Leischker, Christoph Lübbert, Friederike Maechler, Sophie-Susann Merbecks, Nadia Minarovic, Jennifer C. Moïsi, Lutz von Müller, Phillip A. Reuken, Thomas Weinke, Holly Yu, Alexander Mellmann   +15 more
doaj   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source