Results 11 to 20 of about 143,361 (253)
Clostridioides difficile pathogenesis and control
Nature Reviews MicrobiologyClostridioides difficile infection (CDI) continues to be a notable burden worldwide, both in terms of patient mortality and morbidity, and the economic costs associated with treatment, diagnosis and management. The epidemiology of C. difficile has changed markedly over the decades, with high CDI rates driven by clinical pressures exacerbated by the ...
Caroline H Chilton +2 more
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Newer Therapeutics to Selectively Kill Clostridioides difficile and Restore the Microbiome [PDF]
Infectious Disease ReportsBackground: The antibiotic ibezapolstat and the live biotherapeutic product live-JSLM are promising future approaches for treating Clostridioides difficile infection.
Guido Granata, Nicola Petrosillo
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Nature Communications, 2022 Clostridioides difficile infection (CDI) results in significant morbidity and mortality in hospitalised patients. Here the authors engineer probiotics to restore intestinal bile salt metabolism in response to antibiotic-induced microbiome dysbiosis ...
Elvin Koh +7 more
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Pathogenicity and virulence of Clostridioides difficile
Virulence, 2022 Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhea, and is responsible for a spectrum of diseases characterized by high levels of recurrence, morbidity, and mortality.
Jessica E. Buddle, Robert P. Fagan
semanticscholar +5 more sources
Extraintestinal Clostridioides difficile infection
IDCases, 2020 Clostridioides (Clostridium) difficile is the major cause of healthcare antibiotic-associated diarrhoea. However, extra-intestinal manifestations of Clostridioides (Clostridium) difficile infection (CDI) (including bacteremia and tissue infection) are ...
Zhao Hai +6 more
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Clostridioides difficile infection: an update.
Infezioni in MedicinaClostridioides difficile (C. difficile) is a Gram-positive, spore-forming anaerobic bacterium emerged as a leading cause of diarrhea globally. CDI's (Clostridioides difficile infection) impact on healthcare systems is concerning due to high treatment ...
Federica Salvati +4 more
semanticscholar +3 more sources
International Journal of Medical Microbiology, 2021 Clostridioides difficile is a Gram positive spore-forming rod and mainly responsible for nosocomial diarrhea in developed nations. Molecular and antimicrobial surveillance is important for monitoring the strain composition including genotypes of high ...
Ahmed Mohamed Mostafa Abdrabou +9 more
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Frontiers in Microbiology, 2022 The immunological response against Clostridioides difficile (C. difficile) is crucial for an improved understanding of disease mechanisms and the development of novel therapeutic strategies.
Sophie Roth +10 more
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Plasmids of Clostridioides difficile
Current Opinion in Microbiology, 2022 Plasmids are ubiquitous in the bacterial world. In many microorganisms, plasmids have been implicated in important aspects of bacterial physiology and contribute to horizontal gene transfer. In contrast, knowledge on plasmids of the enteropathogen Clostridioides difficile is limited, and there appears to be no phenotypic consequence to carriage of many
Smits, W.K., Roseboom, A.M., Corver, J.
openaire +3 more sources
International Journal of Infectious Diseases, 2022 Recently, the recommendations for the treatment of Clostridioides difficile infection (CDI) have been updated. However, in addition to the clinical efficacy data, the drug of choice should ideally represent optimal antimicrobial stewardship, with an ...
Marcela Krutova, Mark Wilcox, Ed Kuijper
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