Results 21 to 30 of about 23,676 (213)

Clostridioides difficile, a New “Superbug”

Microorganisms, 2023
Clostridioides difficile is a Gram-positive, spore-forming, anaerobic bacterium. The clinical features of C. difficile infections (CDIs) can vary, ranging from the asymptomatic carriage and mild self-limiting diarrhoea to severe and sometimes fatal pseudomembranous colitis. C.
Rumyana Markovska, Georgi Dimitrov, Raina Gergova, Lyudmila Boyanova   +3 more
openaire   +3 more sources

Clostridioides difficile epidemiology in India

Anaerobe, 2022
Clostridioides difficile infection (CDI) continues to affect hospitalized patients and community populations worldwide. In contrast to the substantial resources invested in the diagnosis and prevention of CDI in high-income countries, this anaerobic toxigenic bacterium has been largely overlooked in low-and-middle-income countries (LMICs) such as India,
Tanya M. Monaghan, Rima Biswas, Ashish Satav, Shrikant Ambalkar, Rajpal Singh Kashyap   +4 more
openaire   +2 more sources

Engineering probiotics to inhibit Clostridioides difficile infection by dynamic regulation of intestinal metabolism

Nature Communications, 2022
Clostridioides difficile infection (CDI) results in significant morbidity and mortality in hospitalised patients. Here the authors engineer probiotics to restore intestinal bile salt metabolism in response to antibiotic-induced microbiome dysbiosis ...
Elvin Koh, In Young Hwang, Hui Ling Lee, Ryan De Sotto, Jonathan Wei Jie Lee, Yung Seng Lee, John C. March, Matthew Wook Chang   +7 more
doaj   +1 more source

In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden

Microbiology Spectrum, 2021
Clostridioides difficile infection represents a growing clinical challenge. The new compound omadacycline is a potential treatment alternative, as many antibiotics have limited activity or are rarely used due to costs and side effects.
Angela Camporeale, Chaitanya Tellapragada, Jelena Kornijenko, Carl Erik Nord, Christian G. Giske   +4 more
doaj   +1 more source

Pathogenicity and virulence of Clostridioides difficile

Virulence, 2023
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhea, and is responsible for a spectrum of diseases characterized by high levels of recurrence, morbidity, and mortality. Treatment is complex, since antibiotics constitute both the main treatment and the major risk factor for infection.
Jessica E. Buddle, Robert P. Fagan
openaire   +3 more sources

Analysis of the impact of secondary prophylaxis on recurrence in critically ill adults

SAGE Open Medicine, 2020
Introduction: Clostridioides (formerly Clostridium ) difficile infection recurrence in patients re-exposed to antibiotics for treatment of a non- Clostridioides difficile infection is high at approximately 33%. Low-dose per os vancomycin (e.g. 125 mg q12 
Kathryn A Connor, Kelly M Conn
doaj   +1 more source

Clostridioides difficile: Treating Sustained Antibiotic Responders With Fecal Microbiota Transplantation Does Not Improve Efficacy. [PDF]

Clin Infect Dis
Paaske SE, Baunwall SMD, Ianiro G, Iqbal T, Keller J, Kupciskas J, Link A, Mullish BH, Vehreschild MJGT, Dahlerup JF, Hvas CL.   +10 more
europepmc   +3 more sources

Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection

Gut Pathogens, 2021
Background Clostridioides difficile infection (CDI) is an infectious nosocomial disease caused by Clostridioides difficile, an opportunistic pathogen that occurs in the intestine after extensive antibiotic regimens. Results Nine C.
Seung Woo Ahn, Se Hee Lee, Uh Jin Kim, Hee-Chang Jang, Hak-Jong Choi, Hyon E. Choy, Seung Ji Kang, Seong Woon Roh   +7 more
doaj   +1 more source

Clostridioides Difficile Enteritis: Case Report and Literature Review

Antibiotics, 2022
Background: Clostridioides Difficile is a well-known pathogen causing diarrhea of various degrees of severity through associated infectious colitis.
Artsiom Klimko, Cristian George Tieranu, Ana-Maria Curte, Carmen Monica Preda, Ioana Tieranu, Andrei Ovidiu Olteanu, Elena Mirela Ionescu   +6 more
doaj   +1 more source

Rare Clinical Association between Clostridioides difficile Infection and Ischemic Colitis: Case Report and Literature Review

Medicina, 2021
Background and Objectives: Gut microbiota plays an important role in the wellbeing of the host through different interactions between microflora constituents. In certain instances, Clostridioides difficile may pullulate, causing infection with associated
Elena Mirela Ionescu, Ana-Maria Curte, Andrei Ovidiu Olteanu, Carmen Monica Preda, Ioana Tieranu, Artsiom Klimko, Cristian George Tieranu   +6 more
doaj   +1 more source