High sporulation and overexpression of virulence factors in biofilms and reduced susceptibility to vancomycin and linezolid in recurrent Clostridium [Clostridioides] difficile infection isolates [PDF]
, 2019 Clostridium [Clostridioides] difficile infection (CDI) is one of the leading causes of diarrhea associated with medical care worldwide, and up to 60% of patients with CDI can develop a recurrent infection (R-CDI). A multi-species microbiota biofilm model
Baines, Simon +9 more
core +2 more sources
Epidemiologia da Infeção por Clostridioides Difficile em Portugal: um Estudo Retrospetivo, Observacional em Doentes Hospitalizados [PDF]
, 2022 Introduction: Clostridioides difficile is the main cause of healthcare-associated diarrhea in Europe and North America. The aim of this study was to characterize the epidemiology and clinical burden of Clostridioides difficile infection among ...
Cunha, F +14 more
core +2 more sources
Analysis of the impact of secondary prophylaxis on recurrence in critically ill adults
SAGE Open Medicine, 2020 Introduction: Clostridioides (formerly Clostridium ) difficile infection recurrence in patients re-exposed to antibiotics for treatment of a non- Clostridioides difficile infection is high at approximately 33%. Low-dose per os vancomycin (e.g. 125 mg q12
Kathryn A Connor, Kelly M Conn
doaj +1 more source
Microbiology Spectrum, 2021 Clostridioides difficile infection represents a growing clinical challenge. The new compound omadacycline is a potential treatment alternative, as many antibiotics have limited activity or are rarely used due to costs and side effects.
Angela Camporeale +4 more
doaj +1 more source
Environmental contamination with clostridioides (Clostridium) difficile in Vietnam [PDF]
, 2023 AIMS: To investigate the prevalence, molecular type, and antimicrobial susceptibility of Clostridioides difficile in the environment in Vietnam, where little is known about C. difficile.
Bui, Huong T. T. +7 more
core +2 more sources
Anaerobic 4-hydroxyproline utilization: Discovery of a new glycyl radical enzyme in the human gut microbiome uncovers a widespread microbial metabolic activity. [PDF]
, 2018 The discovery of enzymes responsible for previously unappreciated microbial metabolic pathways furthers our understanding of host-microbe and microbe-microbe interactions. We recently identified and characterized a new gut microbial glycyl radical enzyme
Balskus, Emily P +2 more
core +1 more source
Clostridioides difficile Infection [PDF]
Annals of Internal Medicine, 2018 Clostridioides difficile (formerly Clostridium difficile) infection is the most frequently identified health care-associated infection in the United States. C difficile has also emerged as a cause of community-associated diarrhea, resulting in increased incidence of community-associated infection.
Alice Y, Guh, Preeta K, Kutty
openaire +2 more sources
Developing Gut Microbiota Exerts Colonisation Resistance to Clostridium (syn. Clostridioides) difficile in Piglets [PDF]
, 2019 Clostridium (syn. Clostridioides) difficile is considered a pioneer colonizer and may cause gut infection in neonatal piglets. The aim of this study was to explore the microbiota-C. difficile associations in pigs.
Dadi, Temesgen Hailemariam +3 more
core +1 more source
Cost-Effectiveness Analysis of Bezlotoxumab Added to Standard of Care Versus Standard of Care Alone for the Prevention of Recurrent Clostridium difficile Infection in High-Risk Patients in Spain [PDF]
, 2018 Introduction Clostridium difficile infection (CDI) is the major cause of infectious nosocomial diarrhoea and is associated with considerable morbidity, mortality and economic impact.
Aceituno, Susana +7 more
core +3 more sources
Clostridioides Difficile Enteritis: Case Report and Literature Review
Antibiotics, 2022 Background: Clostridioides Difficile is a well-known pathogen causing diarrhea of various degrees of severity through associated infectious colitis.
Artsiom Klimko +6 more
doaj +1 more source