International Journal of Infectious Diseases, 2022 Recently, the recommendations for the treatment of Clostridioides difficile infection (CDI) have been updated. However, in addition to the clinical efficacy data, the drug of choice should ideally represent optimal antimicrobial stewardship, with an ...
Marcela Krutova, Mark Wilcox, Ed Kuijper
doaj
Frontiers in Cellular and Infection Microbiology, 2022 In adults, Clostridioides difficile infections are associated with alterations of the intestinal bacterial populations. Although preterm neonates (PN) are frequently colonized by C. difficile, limited data are available regarding the relationship between
Jeanne Couturier +13 more
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Comparison of fidaxomicin, metronidazole and vancomycin for initial episode and recurrence of Clostridioides difficile infection - An observational cohort study [PDF]
HeliyonObjectives: The main aim of this study was to compare the clinical outcomes of patients attended in our area with Clostridioides difficile infection (CDI) (sustained cure, recurrence or death) in relation to treatment to normal or hypervirulent C ...
Marcos Hernando-Gozalo +4 more
doaj +3 more sources
Protection of hamsters from mortality by reducing fecal moxifloxacin concentration with DAV131A in a model of moxifloxacin-induced Clostridium difficile colitis [PDF]
Antimicrobial Agents and Chemotherapy, American Society for
Microbiology, 2017, 2017 BackgroundLowering the gut exposure to antibiotics during treatments can prevent microbiota disruption. We evaluated the effect of an activated charcoal-based adsorbent, DAV131A, on fecal free moxifloxacin concentration and mortality in a hamster model of moxifloxacin-induced C.
arxiv +1 more source
Opportunities for Nanomedicine in Clostridioides difficile Infection [PDF]
Antibiotics, 2021 Clostridioides difficile, a spore-forming bacterium, is a nosocomial infectious pathogen which can be found in animals as well. Although various antibiotics and disinfectants were developed, C. difficile infection (CDI) remains a serious health problem. C.
Pei-Wen Wang +3 more
openaire +3 more sources
Clostridioides difficile Infection in an Italian Tertiary Care University Hospital: A Retrospective Analysis [PDF]
, 2023 Clostridioides difficile infection (CDI) is a significant cause of morbidity and mortality, mostly in frail patients. Notification is not mandatory in Italy, and data on incidence, risk of death, and recurrence are lacking.
Albano, Chiara +13 more
core +1 more source
Cytotoxic synergism of Clostridioides difficile toxin B with proinflammatory cytokines in subjects with inflammatory bowel diseases [PDF]
, 2023 Clostridioides difficile (C. difficile) is progressively colonizing humans and animals living with humans. During this process, hypervirulent strains and mutated toxin A and B of C. difficile (TcdA and TcdB) are originating and developing.
Bassotti, Gabrio +4 more
core +1 more source
Uncovering the Harms of Treating Clostridioides difficile Colonization
mSphere, 2021 Patients with toxin-negative Clostridioides ...
Christopher R. Polage +1 more
doaj +1 more source
Epidemiology of Clostridioides difficile in South Africa
PLOS ONE, 2021 Background Clostridioides difficile (CD) is the most common healthcare-associated enteric infection. There is currently limited epidemiological evidence on CD incidence in South Africa. Aim To estimate the burden of CD infection (CDI) in the South African public sector between 1 July 2016 and 30 June 2017.
Pieter de Jager +4 more
openaire +5 more sources
Developing Gut Microbiota Exerts Colonisation Resistance to Clostridium (syn. Clostridioides) difficile in Piglets [PDF]
, 2019 Clostridium (syn. Clostridioides) difficile is considered a pioneer colonizer and may cause gut infection in neonatal piglets. The aim of this study was to explore the microbiota-C. difficile associations in pigs.
Dadi, Temesgen Hailemariam +3 more
core +1 more source